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Drug-Induced Gastritis

  • Reference work entry
  • First Online:
Pathology of the Gastrointestinal Tract

Part of the book series: Encyclopedia of Pathology ((EP))

  • 675 Accesses

Synonyms

Iatrogenic gastritis

Definition

Drug-induced gastritis refers to gastric mucosal injury related to the adverse effects of therapeutic/pharmacological agents.

Clinical Features

  • Incidence

    The incidence varies significantly between agents, but over the last 10 years, there has been greater recognition of iatrogenic-related gastric mucosal alteration.

  • Presentation

    Drug-induced gastritis is characterized by the diversity and the nonspecific nature of the presentation. Some patients are asymptomatic, but common clinical manifestations include upper abdominal discomfort or pain, loss of appetite, nausea, and vomiting. More severe presentations may include hematochezia, melena, hemorrhagic shock, and even gastric perforation.

  • Age

    Drug-induced gastritis is more frequently diagnosed in adults and seniors. This is likely directly related to the increased use of therapeutic agents in older age-groups, such as anti-inflammatory or antioncologic therapy. However, younger patients are also...

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References and Further Reading

  • Haig, A., et al. (2006). Iron-induced mucosal injury to the upper gastrointestinal tract. Histopathology, 48(7), 808–12.

    Article  CAS  Google Scholar 

  • Lauwers, G. Y., Fujita, H., Nagata, K., & Shimizu, M. (2010). Pathology of non-Helicobacter pylori gastritis: Extending the histopathologic horizons. Journal of Gastroenterology, 45(2), 131–45. Review.

    Article  Google Scholar 

  • Oble, D. A., Mino-Kenudson, M., Goldsmith, J., Hodi, F. S., Seliem, R. M., Dranoff, G., Mihm, M., Hasserjian, R., & Lauwers, G. Y. (2008). Alpha-CTLA-4 mAb-associated panenteritis: A histologic and immunohistochemical analysis. The American Journal of Surgical Pathology, 32, 1130–7.

    Article  Google Scholar 

  • Xiao, S. Y., Zhao, L., Hart, J., & Semrad, C. E. (2013). Gastric mucosal necrosis with vascular degeneration induced by doxycycline. The American Journal of Surgical Pathology, 37, 259–63.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pathology, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., 11217, Taipei, Taiwan

    Wen-Yih Liang

  2. Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St., Warren 219, 02114, Boston, MA, USA

    Gregory Y. Lauwers

Authors
  1. Wen-Yih Liang
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  2. Gregory Y. Lauwers
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Corresponding author

Correspondence to Wen-Yih Liang .

Editor information

Editors and Affiliations

  1. Faculty of Medicine of Porto University, Centro Hospitalar São João and Ipatimup/i3S, Porto, Portugal

    Fátima Carneiro

  2. Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa de Francisco Gentil, Lisbon, Portugal

    Paula Chaves

  3. Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal

    Paula Chaves

  4. Department of Pathology, Ankara University Medical School, Sihhiye, Ankara, Turkey

    Arzu Ensari

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© 2017 Springer International Publishing AG

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Cite this entry

Liang, WY., Lauwers, G.Y. (2017). Drug-Induced Gastritis. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1612

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  • DOI: https://doi.org/10.1007/978-3-319-40560-5_1612

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40559-9

  • Online ISBN: 978-3-319-40560-5

  • eBook Packages: MedicineReference Module Medicine

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