Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Drug-Induced Gastritis

  • Wen-Yih LiangEmail author
  • Gregory Y. Lauwers
Reference work entry


Iatrogenic gastritis


Drug-induced gastritis refers to gastric mucosal injury related to the adverse effects of therapeutic/pharmacological agents.

Clinical Features

  • Incidence

    The incidence varies significantly between agents, but over the last 10 years, there has been greater recognition of iatrogenic-related gastric mucosal alteration.

  • Presentation

    Drug-induced gastritis is characterized by the diversity and the nonspecific nature of the presentation. Some patients are asymptomatic, but common clinical manifestations include upper abdominal discomfort or pain, loss of appetite, nausea, and vomiting. More severe presentations may include hematochezia, melena, hemorrhagic shock, and even gastric perforation.

  • Age

    Drug-induced gastritis is more frequently diagnosed in adults and seniors. This is likely directly related to the increased use of therapeutic agents in older age-groups, such as anti-inflammatory or antioncologic therapy. However, younger patients are also...

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References and Further Reading

  1. Haig, A., et al. (2006). Iron-induced mucosal injury to the upper gastrointestinal tract. Histopathology, 48(7), 808–12.CrossRefGoogle Scholar
  2. Lauwers, G. Y., Fujita, H., Nagata, K., & Shimizu, M. (2010). Pathology of non-Helicobacter pylori gastritis: Extending the histopathologic horizons. Journal of Gastroenterology, 45(2), 131–45. Review.CrossRefGoogle Scholar
  3. Oble, D. A., Mino-Kenudson, M., Goldsmith, J., Hodi, F. S., Seliem, R. M., Dranoff, G., Mihm, M., Hasserjian, R., & Lauwers, G. Y. (2008). Alpha-CTLA-4 mAb-associated panenteritis: A histologic and immunohistochemical analysis. The American Journal of Surgical Pathology, 32, 1130–7.CrossRefGoogle Scholar
  4. Xiao, S. Y., Zhao, L., Hart, J., & Semrad, C. E. (2013). Gastric mucosal necrosis with vascular degeneration induced by doxycycline. The American Journal of Surgical Pathology, 37, 259–63.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of PathologyTaipei Veterans General HospitalTaipeiTaiwan
  2. 2.Department of PathologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA