Autoimmune chronic gastritis; Autoimmune metaplastic atrophic gastritis (AMAG); Autoimmune-associated gastritis; Type A gastritis
Autoimmune gastritis is an immune-mediated gastritis, and in its development, anti-parietal cell and anti-intrinsic factor antibodies are involved. There is typical loss of oxyntic cells in the gastric corpus and fundus. Autoimmune gastritis is characterized by hypochlorhydria or achlorhydria, hypergastrinemia, low pepsinogen I/pepsinogen II ratio, and vitamin B12 deficiency that can lead to pernicious anemia. The declining incidence of Helicobacter pylori gastritis parallels a growing clinical focus on autoimmune gastritis.
Hypochlorhydria results from loss of oxyntic mucosa and possibly from the disruption of normal parietal cell maturation. This can already occur in patients with a large number of preserved parietal cells, suggesting that there may be a role for anti-proton pump antibodies or inhibitory lymphokines released by...
References and Further Reading
- Odze, R. D., & Goldblum, J. R. (2009). Surgical pathology of the GI tract, liver, biliary tract, and pancreas (2nd ed.). Philadelphia: Saunders.Google Scholar
- Rugge, M., Fassan, M., Pizzi, M., Zorzetto, V., Maddalo, G., Realdon, S., et al. (2012). Autoimmune gastritis: Histology phenotype and OLGA staging. Alimentary Pharmacology & Therapeutics, 35(12), 1460–1466.Google Scholar