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Gastric Epithelial Dysplasia

  • Reference work entry
  • First Online:
Pathology of the Gastrointestinal Tract

Part of the book series: Encyclopedia of Pathology ((EP))

  • 259 Accesses

Synonyms

Gastric intraepithelial neoplasia, adenoma.

Definition

Gastric epithelial dysplasia represents unequivocal gastric epithelial neoplastic proliferation characterized by variable cytological and architectural atypia, without convincing evidence of invasive growth.

Clinical Features

  • Incidence

    Incidence of gastric epithelial dysplasia shows considerable geographic differences and is usually associated with the regional prevalence of Helicobacter pylori infection. The incidence of dysplasia varies from 0.5% to 4% in western populations and from 9% to 20% in high-risk areas for gastric carcinomas.

  • Age

    The incidence of gastric epithelial dysplasia increases with age. It is much more prevalent after sixth decade.

  • Sex

    Gastric epithelial dysplasia is more frequent in males than in females, with a male to female ratio of 1.2–3:1.

  • Site

    Gastric epithelial dysplasia occurs more frequently in the gastric antrum and incisura angularis, although it can involve the whole stomach.

    ...

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References and Further Reading

  • de Vries, A. C., & Kuipers, E. J. (2007). Epidemiology of premalignant gastric lesions: Implications for the development of screening and surveillance strategies. Helicobacter, 12(Suppl 2), 22–31. Review. PubMed PMID: 17991173.

    PubMed  Google Scholar 

  • Dixon, M. F. (2002). Gastrointestinal epithelial neoplasia: Vienna revisited. Gut, 51(1), 130–131. PubMed PMID: 12077106; PubMed Central PMCID: PMC1773259.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lauwers, G. Y., & Riddell, R. H. (1999). Gastric epithelial dysplasia. Gut, 45(5), 784–790. Review. PubMed PMID: 10517922; PubMed Central PMCID:PMC1727726.

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  • Raftopoulos, S. C., Kumarasinghe, P., de Boer, B., Iacobelli, J., et al. (2012). Gastric intraepithelial neoplasia in a Western population. European Journal of Gastroenterology and Hepatology, 24(1), 48–54. PubMed PMID: 22081007.

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  • You, W. C., Blot, W. J., Li, J. Y., Chang, Y. S., Jin, M. L., Kneller, R., Zhang, L., Han, Z. X., Zeng, X. R., & Liu, W. D. (1993). Precancerous gastric lesions in a population at high risk of stomach cancer. Cancer Research, 53(6), 1317–1321. PubMed Central PMCID:PMC1 8443811.

    CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Centro hospitalar de Vila Nova de Gaia/Espinho, Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr. Roberto Frias S/N, 4200-0465, Porto, Portugal

    Xiaogang Wen

Authors
  1. Xiaogang Wen
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Corresponding author

Correspondence to Xiaogang Wen .

Editor information

Editors and Affiliations

  1. Faculty of Medicine of Porto University, Centro Hospitalar São João and Ipatimup/i3S, Porto, Portugal

    Fátima Carneiro

  2. Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa de Francisco Gentil, Lisbon, Portugal

    Paula Chaves

  3. Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal

    Paula Chaves

  4. Department of Pathology, Ankara University Medical School, Sihhiye, Ankara, Turkey

    Arzu Ensari

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Wen, X. (2017). Gastric Epithelial Dysplasia. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1585

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  • DOI: https://doi.org/10.1007/978-3-319-40560-5_1585

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40559-9

  • Online ISBN: 978-3-319-40560-5

  • eBook Packages: MedicineReference Module Medicine

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