C-Kit (CD117), Gastrointestinal Stromal Tumors (GISTs)
CD117; C-Kit synonyms include C-Kit; Mast/stem cell growth factor receptor Kit; p145 c-kit; PBT; Piebald trait protein; Proto-oncogene c-Kit; Proto-oncogene tyrosine-protein kinase Kit; SCFR; Soluble KIT variant 1; Tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
C-Kit (CD117) is an antibody that identifies the C-Kit protein.
Molecule Type and Chemical Structure
C-Kit belongs to the type III receptor tyrosine kinase (RTK) subfamily, whose members include platelet-derived growth factor receptors α and β (PDGFRα and PDGFRβ) (Roskoski 2005). All type III RTKs contain five immunoglobulin-like domains in their extracellular ligand-binding region followed by a single transmembrane domain and a cytoplasmic tyrosine kinase domain interrupted by a large kinase insert. The ligand of KIT is known as stem cell factor. C-Kit(the gene) is transcribed and ultimately translated into the KIT protein, a transmembrane receptor tyrosine...
References and Further Reading
- Hirota, S., Isozaki, K., Moriyama, Y., Hashimoto, K., Nishida, T., Ishiguro, S., Kawano, K., Hanada, M., Kurata, A., Takeda, M., Muhammad, T. G., Matsuzawa, Y., Kanakura, Y., Shinomura, Y., & Kitamura, Y. (1998). Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science, 279, 577–580.PubMedGoogle Scholar
- Lennartsson, J., & Rönnstrand, L. (2006). The stem cell factor receptor/c-Kit as a drug target in cancer. Current Cancer Drug Targets, 6, 561–571.Google Scholar