Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Basaloid Squamous Cell Carcinoma, Esophageal

  • Maria Gabriela GasparinhoEmail author
  • Isabel Fonseca
Reference work entry


There are no current synonyms for this neoplasm. Historically, it has been confused with another neoplastic entity, namely adenoid cystic carcinoma.


A malignant epithelial neoplasm composed of closely packed cells with hyperchromatic nuclei and scant cytoplasm, with a solid growth pattern, small cystic spaces, and foci of necrosis. The diagnosis depends on the demonstration of squamous cell dysplasia/carcinoma in situ in the overlying mucosa.

Clinical Features

  • Incidence

    Basaloid squamous cell carcinoma (BSCC) is a rare entity and there are no global worldwide incidence data available. In most published series, the incidence ranges from 0.07% to 11.3% of all esophageal carcinomas.

  • Age

    In the published series, the mean age at the time of diagnosis is around 60 years.

  • Sex

    There is a slight predominance in males.

  • Site

    This type of neoplasm has been classically described in the upper aerodigestive tract, namely at the larynx and the esophagus, but it can also be...

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References and Further Reading

  1. Chen, S.-B., Weng, H.-R., Wang, G., Yang, W.-P., Li, H., Liu, D.-T., & Chen, Y.-P. (2012). Basaloid squamous cell carcinoma of the esophagus. Journal of Cancer Research and Clinical Oncology, 138(7), 1165–1171.CrossRefGoogle Scholar
  2. Imamhasan, A., Mitomi, H., Saito, T., Hayashi, T., Takahashi, M., Kajiyama, Y., & Yao, T. (2012). Immunohistochemical and oncogenetic analyses of the esophageal basaloid squamous cell carcinoma in comparison with conventional squamous cell carcinomas. Human Pathology, 43(11), 2012–2023.CrossRefGoogle Scholar
  3. Sarbia, M., Verreet, P., Bittinger, F., Dutkowski, P., Heep, H., Willers, R., & Gabbert, H. E. (1997). Basaloid squamous cell carcinoma of the esophagus – Diagnosis and prognosis. Cancer, 79(10), 1871–1878.CrossRefGoogle Scholar
  4. Zhang, X.-H., Sun, G.-Q., Zhou, X.-J., Guo, H.-F., & Zhang, T.-H. (1998). Basaloid squamous carcinoma of esophagus: A clinicopathological, immunohistochemical and electron microscopic study of sixteen cases. World Journal of Gastroenterology, 4(5), 397–403.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing 2017

Authors and Affiliations

  1. 1.Instituto Português de Oncologia de Lisboa Francisco GentilLisboaPortugal
  2. 2.Instituto de Anatomia Patológica da Faculdade de Ciências da Saúde da Universidade da Beira InteriorCovilhãPortugal
  3. 3.Serviço de Anatomia Patológica, Instituto Português de Oncologia Francisco Gentil – LisboaLisbonPortugal
  4. 4.Faculdade de Medicina de Lisboa, Instituto de Anatomia PatológicaLisbonPortugal