Adenosquamous Carcinoma, Upper GI Tract
Synonyms
There are no current synonyms for this neoplasm. Historically, it has been often confounded with mucoepidermoid carcinoma.
Definition
A malignant epithelial neoplasm that has mixed elements of glandular and squamous cell differentiation, which remains clearly distinguishable within the tumor.
Clinical Features
Incidence
Adenosquamous carcinoma (ASC) is a rare disease. No worldwide incidence data is available. In the largest published series, it represented 1.0% of all esophageal cancers.
Age
In the largest published series, patients’ age range from 51 to 85 years, with a mean age of 64 years.
Sex
The disease is more frequent in males.
Site
Adenosquamous carcinoma is somewhat more frequent in the middle and lower thirds of the esophagus.
Treatment
Surgery is the treatment of choice and can be followed by radiotherapy. This particular histological type does not change the usual treatment for esophageal carcinomas.
Outcome
ASC seems to have a better prognosis than conventional...
References and Further Reading
- Alos, L., Castillo, M., Nadal, A., Caballero, M., Mallofre, C., Palacin, A., & Cardesa, A. (2004). Adenosquamous carcinoma of the head and neck: Criteria for diagnosis in a study of 12 cases. Histopathology, 44, 570–579.PubMedCrossRefGoogle Scholar
- Rees, B. P., Rouse, R. W., Wit, M., Noesel, C. J. M., Tytgat, G. N. J., Lanschot, J. B., & Offerhaus, G. J. A. (2002). Molecular evidence for the same clonal origin of both components of an adenosquamous Barrett carcinoma. Gastroenterology, 122, 784–788.PubMedCrossRefGoogle Scholar
- Yachida, S., Nakanishi, Y., Shimoda, T., Nimura, S., Igaki, H., Tachimori, Y., & Kato, H. (2004). Adenosquamous carcinoma of the esophagus, clinicopathologic study of 18 cases. Oncology, 66, 218–225.PubMedCrossRefGoogle Scholar
- Ylagan, L. R., Scholes, J., & Demopoulos, R. (2000). CD44, a marker of squamous differentiation in adenosquamous neoplasms. Archives of Pathology and Laboratory Medicine, 124, 212–215.PubMedGoogle Scholar