Adenoma, Upper Gastrointestinal Tract
Intestinal-type adenoma; Polyps
An adenoma is defined by the World Health Organization as a “circumscribed benign neoplasm composed of tubular and/or villous structures lined by dysplastic epithelium.” Gastric adenomas are depicted as raised, protruding, or polypoid lesions composed of dysplastic epithelium that project above the surrounding gastric mucosa and therefore distinct from flat mucosal dysplasia or intraepithelial dysplasia like formerly termed flat adenomas or depressed adenomas. The grade of the dysplastic epithelium that comprises the adenoma is classified as low grade or high grade. Gastric adenomas are histologically divided into intestinal- and gastric- types based on the type of glandular epithelium they display. In this entry, intestinal-type gastric adenoma is being discussed.
Sporadic gastric adenomas often occur in a background of chronic gastritis with atrophy and intestinal metaplasia. Adenomas may actually represent polypoid areas of...
References and Further Reading
- Abraham, S. C., Mongomery, E. A., Singh, V. K., Yardley, J. H., & Wu, T. T. (2002). Gastric adenomas: Intestinal-type and gastric-type adenomas differ in the risk of adenocarcinoma and presence of background mucosal pathology. The American Journal of Surgical Pathology, 26(10), 1276–1285.PubMedCrossRefGoogle Scholar
- Park do, Y., Srivastava, A., Kim, G. H., Mino-Kenudson, M., Deshpande, V., Zukerberg, L. R., et al. (2008). Adenomatous and foveolar gastric dysplasia: Distinct patterns of mucin expression and background intestinal metaplasia. The American Journal of Surgical Pathology, 32(4), 524–533.PubMedCrossRefGoogle Scholar