Peptic Duodenal Disease
Chronic (peptic) duodenitis; Chronic active duodenitis; Chronic nonspecific duodenitis; H. pylori-associated chronic duodenitis; Peptic ulcer disease
Peptic duodenal disease represents a continuum of the same disease process of acute and chronic inflammation of the duodenal mucosa resulting from the toxic effects of excess gastric acid. In the setting of increased gastric acid secretion, such as in antral predominant H. pylori gastritis, duodenal inflammation and ulceration may occur. Chronic H. pylori infection is highly associated with peptic disease of the duodenum in more than 80% of the cases. It is also commonly seen in patients who smoke, take NSAIDs chronically for other conditions, have renal insufficiency, or have duodenal immobility. The clinical picture is characterized by burning epigastric pain relieved with food ingestion. In severe cases the pain may be accompanied by nausea and vomiting.
It is estimated to affect up to...