Anal condyloma is a benign squamous epithelial lesion caused by Human Papilloma Virus (HPV) infection.
Several pathways can transmit HPV: sexual contact, autoinoculation, or contact with infected materials. The incubation period usually lasts 2–3 months before the development of condyloma. HPV 6 and 11 are the cause of over 90% of the exophytic anal warts (anal condyloma acuminatum), and they tend to be associated with low-grade dysplastic cellular changes (or anal intraepithelial neoplasia – AIN), and with other low-risk HPV subtypes such as 16 and 39. HPV 16 and 18 are responsible for most of the chronic infections that cause flat squamous lesions, often with high-grade dysplasia, favoring the development of squamous cell carcinoma (with other high-risk subtypes of HPV such as 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 69).
Risk factors for the development of anal or perianal warts are: immunosuppression (iatrogenic on long-term steroids for connective...