Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Microscopic Colitis

  • Arzu Ensari
Reference work entry


Collagenous colitis; Lymphocytic colitis


Microscopic colitis is an umbrella term for two major entities known as lymphocytic (LC) and collagenous colitis (CC). The term microscopic colitis (MC) describes a clinical pathological entity characterized by three elements: (a) a clinical history of chronic watery (non-bloody) diarrhea, (b) a normal or almost normal endoscopic appearance of the colon, and (c) a distinct histologic pattern. The latter can be either that of collagenous colitis (CC) or that of lymphocytic colitis. Therefore, the term microscopic colitis could be applied only from the endoscopic point of view in the presence of normal or almost normal endoscopic examination. Both LC and CC are clinically characterized by chronic watery diarrhea, while other conditions with normal endoscopy and abnormal histology may have other clinical characteristics. The pathogenesis is still not completely understood and probably multifactorial. It is suggested to represent...

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References and Further Reading

  1. Fraser, A. G., Warren, B. F., Chandrapala, R., et al. (2002). Microscopic colitis: A clinical and pathological review. Scandinavian Journal of Gastroenterology, 37, 1241–1245.CrossRefPubMedGoogle Scholar
  2. Kingham, J. G. C., Levison, D. A., Ball, J. A., et al. (1982). Microscopic colitis: A cause of chronic watery diarrhoea. British Medical Journal, 285, 1601–1604.CrossRefPubMedGoogle Scholar
  3. Langner C, Aust D, Ensari A, Villanacci V, Becheanu G, Miehlke S, Geboes K, Münch A; Working Group of Digestive Diseases of the European Society of Pathology (ESP) and the European Microscopic Colitis Group (EMCG) (2015) Histology of microscopic colitis-review with a practical approach for pathologists. Histopathology, 66(5), 613–626.Google Scholar
  4. Sandmeier, D., & Bouzourene, H. (2004). Microscopic colitis with giant cells: A rare new histopathologic subtype? International Journal of Surgical Pathology, 12, 45–48.CrossRefPubMedGoogle Scholar
  5. Saurine, T. J., Brewer, J. M., & Eckstein, R. P. (2004). Microscopic colitis with granulomatous inflammation. Histopathology, 45, 82–86.CrossRefPubMedGoogle Scholar
  6. Tysk, C., Bohr, J., Nyhlin, N., Wickbom, A., & Eriksson, S. (2008). Diagnosis and management of microscopic colitis. World Journal of Gastroenterology, 14(48), 7280–7288.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of PathologyAnkara University Medical SchoolSihhiyeTurkey