Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Carcinoma, Small Intestine

  • Berna SavaşEmail author
Reference work entry


Adenocarcinoma; Small Intestine


Briefly, small intestinal carcinoma is the malignant epithelial tumor of the small intestine. Though the small intestine has a larger surface area and higher rate of epithelial cell turnover, epithelial neoplasms develop less frequently than the other parts of the GI tract. Small intestinal carcinomas are most commonly located in duodenum, usually around the ampulla of Vater. Although adenocarcinomas are the most common primary tumors, small intestine is the most common part of the gastrointestinal tract for involvement by secondary tumors, which are more than twice as common as the primary neoplasm. Like colorectal carcinomas, most of the small intestine carcinomas are sporadic and develop from adenomas. Risk factors for sporadic carcinoma include smoking, alcohol consumption, and fat in diet. Chronic inflammation is an important predisposing condition, including long-standing  Crohn’s diseaseand gluten-sensitive enteropathy (GSE)....

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References and Further Reading

  1. Lee, M. J., Lee, H. S., Choi, Y., & Yang, M. (2003). Expression of mucins and cytokeratins in primary carcinomas of the digestive system. Modern Pathology, 16, 403–410.PubMedGoogle Scholar
  2. Scelo, G., Boffetta, P., Hemminki, K., Pukkala, E., Olsen, J. H., Andersen, A., et al. (2006). Associations between small intestinal cancer and the other primary cancers: An international population-based study. International Journal of Cancer, 118, 189–196.PubMedGoogle Scholar
  3. Schoftenfeld, D., Beebe-Diemmer, J. L., & Vigneau, F. D. (2009). The epidemiology and pathogenesis of neoplasia in small intestine. Annals of Epidemiology, 19, 58–69.Google Scholar
  4. Shepherd, N. A., Carr, N. J., Howe, J. R., Noffsinger, A. E., & Warren, B. F. (2010). Carcinoma of small intestine. In F. T. Bosman, F. Carneiro, R. H. Hruban, & N. D. Theise (Eds.), WHO classification of tumours of the digestive system (pp. 98–101). Lyon, France: IARC.Google Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of PathologyAnkara University Medical SchoolAnkaraTurkey