Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Anal Adenocarcinoma

  • Denis ChatelainEmail author
  • Jean-François Fléjou
Reference work entry


Glandular carcinoma


The most frequent type of anal cancer is squamous cell carcinoma, described in a specific chapter (see entry “ Squamous Cell Carcinoma, Anus”). Other types of anal carcinoma, i.e., adenocarcinoma, neuroendocrine carcinoma, Paget’s disease, and basal cell carcinoma, can also be observed.

Adenocarcinoma of the anal canal is a malignant epithelial tumor arising from glandular cells lining the upper anorectal part of the anal canal, anal transitional zone (ATZ) mucosa, the anal glands, or the epithelium lining of fistulous tracts.

Most adenocarcinomas found in the anal canal represent downward spread from a rectal adenocarcinoma or arise from colorectal-type mucosa lining the ATZ above the dentate line. Rare cases, described as extramucosal perianal adenocarcinomas, develop in pre-existing congenital or acquired anal sinuses or fistulae (in patients with Crohn’s disease). Some adenocarcinomas develop from anal glands or ducts that drain the anal...

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References and Further Reading

  1. Meriden, Z., & Montgomery, E. A. (2012). Anal duct carcinoma: A report of 5 cases. Human Pathology, 43, 216–220.PubMedGoogle Scholar
  2. Shia, J. (2010). An update on tumors of the anal canal. Archives of Pathology and Laboratory Medicine, 134, 1601–1611.PubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Service d’Anatomie PathologiqueCentre Hospitalier et Universitaire du NordAmiensFrance
  2. 2.Faculté de Médecine Pierre et Marie CurieService d’Anatomie et Cytologie Pathologiques, Hôpital Saint-AntoineParisFrance