Living Reference Work Entry

3D Printing and Biofabrication

Part of the series Reference Series in Biomedical Engineering pp 1-23

Date: Latest Version

Development of Nanocellulose-Based Bioinks for 3D Bioprinting of Soft Tissue

  • Paul GatenholmAffiliated withChalmers University of Technology, 3D Bioprinting center Väst (BBV) Email author 
  • , Hector MartinezAffiliated withChalmers University of Technology, 3D Bioprinting center Väst (BBV)CELLINK AB
  • , Erdem KarabulutAffiliated withChalmers University of Technology, 3D Bioprinting center Väst (BBV)
  • , Matteo AmorosoAffiliated withSahlgrenska University Hospital, Plastic Surgery
  • , Lars KölbyAffiliated withSahlgrenska University Hospital, Plastic Surgery
  • , Kajsa MarkstedtAffiliated withChalmers University of Technology, 3D Bioprinting center Väst (BBV)
  • , Erik GatenholmAffiliated withCELLINK AB
  • , Ida HenrikssonAffiliated withChalmers University of Technology, 3D Bioprinting center Väst (BBV)

Abstract

3D bioprinting technology is expected to revolutionize the field of medicine and health care particularly within soft tissue repair and reconstruction. Surgical needs for soft tissue repair include nose, ear, meniscus, and cartilage in joints, as well as repair of damaged nerve tissue, and repair or replacement of damaged skin. 3D bioprinting technology includes a 3D bioprinter, cells, and bioink. Novel bioinks which will be suitable for soft tissue repair need to be developed before 3D bioprinting technology can get into the clinic. Hydrogels and cell-laden hydrogels are very attractive for soft tissue application because of the similarity of mechanical properties and cell environment. The process of design and development of novel bioinks is described in detail in this chapter which includes rheology, printability, cross-linking, long-term stability in medium, cell viability, and stimulation of cells during tissue growth. The commercialization process of bioinks is also described.