The skin is the first line of defense against contaminant exposure.
Removal of contaminated clothing is a first step to contaminant exposure.
Soap and water wash is the most readily available decontamination method but has its limitations.
Many factors influence decontamination including timing of decontamination and chemical nature of contaminant and decontaminant.
KeywordsWash-in effect Skin decontamination Soap and water decontamination Regional variation of percutaneous penetration
- Dancik Y, Bigliardi PL, Bigliardi-Qi M (2015) What happens in the skin? Integrating skin permeation kinetics into studies of developmental and reproductive toxicity following topical exposure. Reproductive Toxicology 58:252–281. https://doi.org/10.1016/j.reprotox.2015.10.001CrossRefPubMedGoogle Scholar
- Feldmann RJ, Maibach HI (1974) Occupational exposure to pesticides: 122–127Google Scholar
- Haddad LM, Winchester JF (1998) Clinical management of poisoning and drug overdose. Saunders, Philadelphia [u.a]Google Scholar
- Hui X, Lamel S, Qiao P, Maibach HI (2013) Isolated human and animal stratum corneum as a partial model for the 15 steps of percutaneous absorption: emphasizing decontamination. Journal of Applied Toxicology part II 33:173–182. https://doi.org/10.1002/jat.2826
- Wester RC, Hui X, Landry T, Maibach HI (1999) In vivo skin decontamination of methylene bisphenyl isocyanate (MDI): soap and water ineffective compared to polypropylene glycol, polyglycol-based cleanser, and corn oil. Toxicological sciences: an official journal of the Society of Toxicology 48:1–4. https://doi.org/10.1093/oxfordjournals.toxsci.a034663