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The Identification of Skin Allergens by In Vivo Assay

  • David A. Basketter
Living reference work entry

Abstract

In vivo assays for skin sensitization are valuable assets, but must not be regarded as 100% accurate.

Guinea pig methods have been superseded by the murine local lymph node assay (LLNA) which is now in the process of being replaced by nonanimal alternatives.

Regulatory classification as a skin sensitizing chemical means that the substance is regarded as significantly active.

A substance which is not classified as a skin sensitizer may still possess a limited potential to cause this effect.

Potency categories are new to regulatory sensitization, but the LLNA EC3 value provides a useful guide to the relative potency of a skin sensitizer.

Keywords

Skin sensitization Local lymph node assay Regulatory classification Potency categorization 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.DABMEB Consultancy Ltd.SharnbrookUK

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