Immunology and Barrier Function of the Skin
A disturbed epidermal barrier may lead to irritant contact dermatitis.
An enhanced penetration through skin barrier may facilitate sensitization.
Immunological effects induced by pre-irritation and barrier alteration may further lead to the induction of allergic Type IV-contact dermatitis and Type I (immediate-type reaction) reactions or aggravate allergic reactions.
KeywordsAtopic eczema (AE) Cornified cell envelope Epidermal permeability barrier Filaggrin Keratohyalin Netherton’s syndrome (NS) Transepidermal water loss (TEWL)
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