Overlap Syndromes and Inflammatory Myopathies

  • Nages Nagaratnam
  • Kujan Nagaratnam
  • Gary Cheuk
Reference work entry

Abstract

The overlap syndromes are characterised by a combination of major features of one or more rheumatic diseases, and mixed connective tissue disease (MCTD) is a special form of overlap syndrome. Inflammatory myopathies are idiopathic and acquired and are differentiated into several subsets, namely, dermatomyositis, the most common; polymyositis, least common; inclusion body myositis, most common above the age of 50; overlap myositis; cancer-associated myositis; and immune-mediated necrotizing myopathy.

Keywords

Overlap syndromes Mixed connective tissue disease (MCTD) Inflammatory myopathies Dermatomyositis Polymyositis 

References

  1. 1.
    Gaubitz M. Epidemiology of connective tissue disorders. Rheumatology 2006(45)Suppl.  https://doi.org/10.1093/rheumatology/kel282.
  2. 2.
    Patient.co.uk Mixed Connective Tissue Disease. MCTD information/Patient. https://atient.info/doctor/mixed-conective-tissue-disease accessed 14/09/2015.
  3. 3.
    Keith MP, Moratz C, Tsokos GC. Anti-RNP immunity: Implications for tissue injury and the pathogenesis of connective tissue disease. Autoimmun Res. 2007;6(4):232–6.CrossRefGoogle Scholar
  4. 4.
    Hoffman RW, Maldonado ME. Immune pathogenesis of Mixed Connective Tissue Disease: a short analytic review. Clin Immunl. 2008;128(1):8–17.CrossRefGoogle Scholar
  5. 5.
    Dalakas MC, Hohlfeld R. Polymyositis and dermatomyositis. The Lancet. 2003;362:971–82.CrossRefGoogle Scholar
  6. 6.
    Tournadre A. Therapeutic strategy in inflammatory myopathies, polymyositis and dermatomyositis, overlap myositis, and immune-mediated necrotizing myopathy. Rev Med Interne. 2014;35(7):466–7.CrossRefPubMedGoogle Scholar
  7. 7.
    Tansley SL, McHugh NJ, Wedderburn LR. Adult and juvenile dermatomyositis are the distinct clinical features explained by our current understanding of serological and pathogenic mechanisms? Arthritis Res. &Ther. 2013;15:211  https://doi.org/10.1186/ar4198.CrossRefGoogle Scholar
  8. 8.
    Rider LG, Lachenbruch PA, Monroe JB, Ravelli A, Cabalar I, Feldman BM, et al. Damage extent and predictors in adult and juvenile dermatomyositis and polymyositis as determined with the myositis damage index. Arthritis Rheum. 2009;60:3425–3435.CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Huber AM, Feldman BM. Medium and long term functional outcomes in a multicenter cohort of children with juvenile dermatomyositis. Arthritis Rheum. 2000;43:541–549.CrossRefPubMedGoogle Scholar
  10. 10.
    Bukovac LT, Perica M, Vidovic M, Lamot L, Harjacek M. Juvenile dermatomyositis. Reumatizam. 2012;59(2):63–72.PubMedGoogle Scholar
  11. 11.
    Hill CL. Zhang Y, Sigurgeirsson B, Pukkala E, Mellemkjaer L, Airio A, et al. Frequency of specific cancer types in dermatomyositis and polymyositis: a population –based study. Lancet. 2001;357:96–100.Google Scholar
  12. 12.
    Pautas E, Cherin P, Piette JC, Pelletier S, Wechsler B, Cabane J, et al. Features pf polymyositis and dermatomyositis in the elderly: a case-control study. Clin Exp Rheumatol. 2000;18(2):241–4.PubMedGoogle Scholar
  13. 13.
    Marie I, Hatron PY, Levesque H, Hachulla E, Hellot MF, Michon-Pasturel U, et al. Influence of age on characteristics of polymyositis and dermatomyositis in adults. Medicine (Baltimore). 1999;78(3):139–47.CrossRefPubMedGoogle Scholar
  14. 14.
    Gunawardene H, Betteridge ZE, McHugh NJ. Myositis-specific autoantibodies: their clinical and pathogenic significance in disease expression. Rheumatology. 2009;48:607–612.CrossRefGoogle Scholar
  15. 15.
    Olsen NJ, Park JH, King LE Jr. Amyopathic dermatomyositis. Curr Rheumatol Rep. 2001;3(4):346–511.CrossRefPubMedGoogle Scholar
  16. 16.
    Choy EHS, Isenberg DA. Treatment of dermatomyositis and polymyositis. Rheumatology. 2002;41(1):7–13.CrossRefPubMedGoogle Scholar
  17. 17.
    Bonner IM, van der Meulen MFG, de Visser M, Kalmijn S, van Venroolii WJ, Voskuyl AE, et al. Long term outcome in polymyositis and dermatomyositis. Ann Rheum Dis. 2006; 65(11):1456–1461.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Nages Nagaratnam
    • 1
  • Kujan Nagaratnam
    • 1
  • Gary Cheuk
    • 2
  1. 1.The University of SydneyWestmead Clinical SchoolWestmeadAustralia
  2. 2.Rehabilitation and Aged Care ServiceBlacktown-Mt Druitt HospitalMount DruittAustralia

Personalised recommendations