Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Spindle Cell Lipoma/Pleomorphic Lipoma

  • Bharat RekhiEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_5469-1


Spindle cell/pleomorphic lipoma, together represent a morphological continuum, mostly occur in the neck and upper trunk of older males and are histopathologically characterized by relatively bland spindle cells, admixed with mature adipose tissue, along with variable myxoid stroma, ropey collagen, and pleomorphic, multinucleate giant cells, the latter feature pronounced in the pleomorphic lipoma. These tumors are invariably immunoreactive for CD34.

Clinical Features

Spindle cell and pleomorphic lipomas invariably occur in middle aged and older men, in the form of solitary, small, painless, subcutaneous masses in the posterior neck, shoulder, and upper back (Enzinger and Harvey 1975; Angervall et al. 1976; Fletcher and Martin-Bates 1987; Shmookler and Enzinger 1981; Azzopardi et al. 1983). Uncommonly, these tumors have been reported at sites, such as extremities and buttock/perineum/inguinal region, face, forehead, and scalp, including dermal locations (Fletcher and...

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References and Further Reading

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Authors and Affiliations

  1. 1.Department of Surgical PathologyTata Memorial Hospital, HBNI UniversityMumbaiIndia