Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Nodular Fasciitis

  • Raf SciotEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_5441-1



Self-limiting (myo)fibroblastic neoplasm, usually occurring in the subcutis.

Clinical Features

  • Incidence

    Nodular fasciitis is relatively common.

  • Age

    It can occur in any age group but most frequently between 20 and 40 years (Montgomery and Meis 1991).

  • Sex

    There is no gender predilection except for the rare cranial variant which is more frequent in boys (Wagner et al. 2016).

  • Site

    It can occur virtually anywhere, but the subcutis of the upper extremities, trunk and head and neck are most frequently involved. Rapid growth is frequent.

  • Treatment

    Conservative surgical excision is sufficient.

  • Outcome

    Excellent prognosis, recurrences are rare.


A nodular unencapsulated and usually well-circumscribed lesion, less than 5 cm, with a myxoid to firm cut surface.


At low power, the tissue culture like aspect is very typical, consisting of microcystic areas with plump myofibroblasts admixed with lymphocytes and extravasated...
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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Imaging and Pathology,Translational Cell and Tissue ResearchKU Leuven, University of LeuvenLeuvenBelgium