Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Nodular Fasciitis

  • Raf SciotEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_5441-1

Synonyms

Definition

Self-limiting (myo)fibroblastic neoplasm, usually occurring in the subcutis.

Clinical Features

  • Incidence

    Nodular fasciitis is relatively common.

  • Age

    It can occur in any age group but most frequently between 20 and 40 years (Montgomery and Meis 1991).

  • Sex

    There is no gender predilection except for the rare cranial variant which is more frequent in boys (Wagner et al. 2016).

  • Site

    It can occur virtually anywhere, but the subcutis of the upper extremities, trunk and head and neck are most frequently involved. Rapid growth is frequent.

  • Treatment

    Conservative surgical excision is sufficient.

  • Outcome

    Excellent prognosis, recurrences are rare.

Macroscopy

A nodular unencapsulated and usually well-circumscribed lesion, less than 5 cm, with a myxoid to firm cut surface.

Microscopy

At low power, the tissue culture like aspect is very typical, consisting of microcystic areas with plump myofibroblasts admixed with lymphocytes and extravasated...
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References

  1. Bekers, E. M., Eijkelenboom, A., Grünberg, K., Roverts, R. C., de Rooy, J. W. J., van der Geest, I. C. M., van Gorp, J. M., Creytens, D., & Flucke, U. (2018). Myositis ossificans – Another condition with USP6 rearrangement, providing evidence of a relationship with nodular fasciitis and aneurysmal bone cyst. Annals of Diagnostic Pathology, 34, 56–59.CrossRefGoogle Scholar
  2. Erber, R., & Agaimy, A. (2018). Misses and near misses in diagnosing nodular fasciitis and morphologically related reactive myofibroblastic proliferations: Experience of a referral center with emphasis on frequency of USP6 gene rearrangements. Virchows Archiv, 473, 351–360.CrossRefGoogle Scholar
  3. Kuklani, R., Robbins, J. L., Chalk, E. C., & Pringle, G. (2016). Intravascular fasciitis: Report of two intraoral cases and review of the literature. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, 121, e19–e25.CrossRefGoogle Scholar
  4. Montgomery, E. A., & Meis, J. M. (1991). Nodular fasciitis. Its morphologic spectrum and immunohistochemical profile. The American Journal of Surgical Pathology, 15, 942–948.CrossRefGoogle Scholar
  5. Wagner, R. D., Wang, E. K., Lloyd, M. S., Lam, S. K., & Khechoyan, D. Y. (2016). Cranial fasciitis: A systematic review and diagnostic approach to a pediatric scalp mass. The Journal of Craniofacial Surgery, 27, e65–e71.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Imaging and Pathology,Translational Cell and Tissue ResearchKU Leuven, University of LeuvenLeuvenBelgium