Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Solitary Circumscribed Neuroma

  • Raf SciotEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_5439-1

Synonyms

Definition

A benign, well-circumscribed intraneural proliferation of Schwann cells and axons.

Clinical Features

  • Incidence

    Not rare but probably underdiagnosed.

  • Age

    Middle-aged adults.

  • Sex

    Equal gender distribution.

  • Site

    There is a strong predilection for the skin of the central face and the mucocutaneous junction, but the oral mucosa can also be affected (Koutlas, Scheithauer, 2010, Leblebici et al., 2019). Acral skin and penis are rare locations.

  • Treatment

    Simple excision is curative.

  • Outcome

    This tumor is entirely benign. There is no association with NF1 or MEN2b.

Macroscopy

Small superficial nodule.

Microscopy

Circumscribed neuroma typically presents as a well-circumscribed cellular nodule composed of short fascicles of typical Schwann cells (Fig. 1). Nuclear palisading is usually not prominent, and hyaline vessels are lacking. Encapsulation is at least focal, but the tumor cells can merge with the surrounding tissue in the superficial part....
This is a preview of subscription content, log in to check access.

References

  1. Koutlas, I. G., & Scheithauer, B. W. (2010). Palisaded encapsulated (“solitary circumscribed”) neuroma of the oral cavity: A review of 55 cases. Head and Neck Pathology, 4, 15–26.CrossRefGoogle Scholar
  2. Leblebici, C., Savli, T. C., Yeni, B., Cin, M., & AEK, A. (2019). Palisaded encapsulated (solitary circumscribed) neuroma: A review of 30 cases. International Journal of Surgical Pathology, 27, 506–514.  https://doi.org/10.1177/1066896919833172.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Imaging and Pathology, Translational Cell and Tissue ResearchKU Leuven, University of LeuvenLeuvenBelgium