Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken


  • Karen FritchieEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_5433-1



Myolipoma is a benign lipomatous tumor composed of mature adipose tissue and well-differentiated smooth muscle cells.

Clinical Features

  • Incidence

    Myolipomas are rare with less than 100 cases reported in the literature (Meis and Enzinger 1991; Fukushima et al. 2017).

  • Age

    The median age is approximately 55 years with a relatively broad range (28–94 years) (Meis and Enzinger 1991; Fukushima et al. 2017).

  • Sex

    Females are predominantly affected (F:M approximately 15:1) (Meis and Enzinger 1991; Fukushima et al. 2017).

  • Site

    Myolipomas typically present as a deep-seated mass in the retroperitoneum, abdominal cavity, or pelvis (Meis and Enzinger 1991; Fukushima et al. 2017).

  • Treatment

    Complete excision is curative.

  • Outcome

    These are benign neoplasms with no recurrences reported following complete surgical excision.


Gross examination reveals a well-circumscribed lobulated or nodular mass generally surrounded by a thin capsule. Deep-seated...

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References and Further Reading

  1. Fukushima, M., Schaefer, I. M., & Fletcher, C. D. (2017). Myolipoma of soft tissue: Clinicopathologic analysis of 34 cases. The American Journal of Surgical Pathology, 41(2), 153–160.CrossRefGoogle Scholar
  2. Hisaoka, M., Sheng, W. Q., Tanaka, A., et al. (2002). HMGIC alterations in smooth muscle tumors of soft tissue and other sites. Cancer Genetics and Cytogenetics, 138(1), 50–55.CrossRefGoogle Scholar
  3. Meis, J. M., & Enzinger, F. M. (1991). Myolipoma of soft tissue. The American Journal of Surgical Pathology, 15(2), 121–125.CrossRefGoogle Scholar
  4. Panagopoulos, I., Gorunova, L., Agostini, A., et al. (2016). Fusion of the HMGA2 and C9orf92 genes in myolipoma with t(9;12)(p22q14). Diagnostic Pathology, 11, 22.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Mayo ClinicRochesterUSA