Intranodal Palisaded Myofibroblastoma
Intranodal hemorrhagic spindle cell tumor with amianthoid fiber
Intranodal palisaded myofibroblastoma (IPM) is a benign mesenchymal tumor arising in the lymph node.
IPM is a very rare tumor of the lymph node. About 70 cases of it have been reported in the English literature since 1968.
IPM has been diagnosed across a wide range of ages, from 19 to 84 year old. It has a tendency to occur in the middle-aged (40–55 year old).
The male-female ratio of affected patients has been reported to be 1.5–2:1. The literature review of 22 cases from 1998 to 2019 (Table 1) revealed a slight male predominance (M:F = 12:10).
Most cases of IPM were reported in the inguinal lymph nodes. Other reported sites include the lymph nodes of the axilla, submandible, neck, and pelvis.
Local excision is carried out in most cases.
Most reported cases have good outcomes. A local recurrence rate of 6% has been reported by Kandemir et al. (
References and Further Reading
- Black, J. O., Zhai, Q. J., Varona, O. B., Ordonez, N. G., & Luna, M. A. (2010). Primary schwannoma in a cervical lymph node. Head & Neck, 32(7), 964–969.Google Scholar
- Bouhajja, L., Jouini, R., Khayat, O., Koubâa, W., Mbarek, C., Ben Brahim, E., & Chedly-Debbiche, A. (2017). Intranodal palisaded myofibroblastoma in a submandibular lymph node. Case Reports in Otolaryngology, 2017 Oct 26. https://doi.org/10.1155/2017/7121485.
- Cimpean, A. M., & Raica, M. (2013). Intranodal hemorrhagic spindle cell tumor with amianthoid fibers – Report of a case with emphasis to mast cell reaction and D2-40 expression. Vivo, 27(3), 395–399.Google Scholar
- Creager, A. J., & Garwacki, C. P. (1999). Recurrent intranodal palisaded myofibroblastoma with metaplastic bone formation. Archives of Pathology & Laboratory Medicine, 123(5), 433–436.Google Scholar
- D’Antonio, A., Addesso, M., Amico, P., & Fragetta, F. (2014). Axillary intranodal palisaded myofibroblastoma: Report of a case associated with chronic mastitis. BMJ Case Reports, 2014 Oct 16. https://doi.org/10.1136/bcr-2014-205877.
- Goldblum, J. R., Folpe, A. L., & Weiss, S. W. (2013). Intranodal palisaded myofibroblastoma. In F. M. Enzinger & S. W. Weiss (Eds.), Enzinger & Weiss’s soft tissue tumors (6th ed., pp. 231–233). Philadelphia: Mosby Elsevier.Google Scholar
- Kleist, B., Poetsch, M., & Schmoll, J. (2003). Intranodal palisaded myofibroblastoma with overexpression of cyclin D1. Archives of Pathology & Laboratory Medicine, 127(8), 1040–1043.Google Scholar
- Laskin, W. B., Lasota, J., Fetsch, J. F., Felisiak-Golabek, A., Wang, Z. F., & Miettinen, M. (2015). Intranodal palisaded myofibroblastoma: Another mesenchymal neoplasm with CTNNB1 (beta-catenin gene) mutations: Clinicopathologic, immunohistochemical, and molecular genetic study of 18 cases. American Journal of Surgical Pathology, 39(2), 197–205.CrossRefGoogle Scholar
- Loizou, P., Evgeniou, E., Scott-Young, N., & Orlando, A. (2013). Intranodal palisaded myofibroblastoma presenting as lymphadenopathy of the groin. BMJ Case Reports, 2013 Jan 11. https://doi.org/10.1136/bcr-2012-006374
- Verset, L., Shumelinsky, F., de Wind, R., Demetter, P., & De Saint Aubain, N. (2019). Spindle cells in aspiration material from an inguinal adenopathy: Possibly a sheep in wolf’s clothing! Histopathology, 2019 Mar 12. https://doi.org/10.1111/his.13859.