Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Intranodal Palisaded Myofibroblastoma

  • Taro Mori
  • Yuichi Yamada
  • Masanori Hisaoka
  • Yoshinao OdaEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_5429-1


Intranodal hemorrhagic spindle cell tumor with amianthoid fiber


Intranodal palisaded myofibroblastoma (IPM) is a benign mesenchymal tumor arising in the lymph node.

Clinical Features

  • Incidence

    IPM is a very rare tumor of the lymph node. About 70 cases of it have been reported in the English literature since 1968.

  • Age

    IPM has been diagnosed across a wide range of ages, from 19 to 84 year old. It has a tendency to occur in the middle-aged (40–55 year old).

  • Sex

    The male-female ratio of affected patients has been reported to be 1.5–2:1. The literature review of 22 cases from 1998 to 2019 (Table 1) revealed a slight male predominance (M:F = 12:10).

  • Site

    Most cases of IPM were reported in the inguinal lymph nodes. Other reported sites include the lymph nodes of the axilla, submandible, neck, and pelvis.

  • Treatment

    Local excision is carried out in most cases.

  • Outcome

    Most reported cases have good outcomes. A local recurrence rate of 6% has been reported by Kandemir et al. (

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References and Further Reading

  1. Altinbas, N. K., Oz, I., Ustuner, E., Gulpinar, B., Peker, E., Akkaya, Z., Peker, A., Ceyhan, K., & Yagci, C. (2016). Intranodal palisaded myofibroblastoma: Radiological and cytological overview. Polish Journal of Radiology, 22(81), 342–346.CrossRefGoogle Scholar
  2. Bhullar, J. S., Herschman, B. R., & Dubay, L. (2013). Intranodal palisaded myofibroblastoma: A new entity of axillary tumors. The American Surgeon, 79(1), E19–E21.PubMedGoogle Scholar
  3. Black, J. O., Zhai, Q. J., Varona, O. B., Ordonez, N. G., & Luna, M. A. (2010). Primary schwannoma in a cervical lymph node. Head & Neck, 32(7), 964–969.Google Scholar
  4. Bouhajja, L., Jouini, R., Khayat, O., Koubâa, W., Mbarek, C., Ben Brahim, E., & Chedly-Debbiche, A. (2017). Intranodal palisaded myofibroblastoma in a submandibular lymph node. Case Reports in Otolaryngology, 2017 Oct 26. https://doi.org/10.1155/2017/7121485.
  5. Cimpean, A. M., & Raica, M. (2013). Intranodal hemorrhagic spindle cell tumor with amianthoid fibers – Report of a case with emphasis to mast cell reaction and D2-40 expression. Vivo, 27(3), 395–399.Google Scholar
  6. Cosenza, U. M., Galati, G., Zofrea, P., Maggi, S., Marasco, A., Castelli, M., Masoni, L., & Brescia, A. (2006). Clinical and biological features of an intranodal palisaded myofibroblastoma. Anticancer Research, 26(3B), 2349–2352.PubMedGoogle Scholar
  7. Creager, A. J., & Garwacki, C. P. (1999). Recurrent intranodal palisaded myofibroblastoma with metaplastic bone formation. Archives of Pathology & Laboratory Medicine, 123(5), 433–436.Google Scholar
  8. D’Antonio, A., Addesso, M., Amico, P., & Fragetta, F. (2014). Axillary intranodal palisaded myofibroblastoma: Report of a case associated with chronic mastitis. BMJ Case Reports, 2014 Oct 16. https://doi.org/10.1136/bcr-2014-205877.
  9. Goldblum, J. R., Folpe, A. L., & Weiss, S. W. (2013). Intranodal palisaded myofibroblastoma. In F. M. Enzinger & S. W. Weiss (Eds.), Enzinger & Weiss’s soft tissue tumors (6th ed., pp. 231–233). Philadelphia: Mosby Elsevier.Google Scholar
  10. Hicham, L., Khmou, M., Najih, M., Zouaidia, F., Sair, K., & El Khannoussi, B. (2015). Intranodal palisaded myofibroblastoma: A case report from an unusual site. Pan African Medical Journal, 22, 78.CrossRefGoogle Scholar
  11. Hisaoka, M., Hashiomoto, H., & Daimaru, Y. (1998). Intranodal palisaded myofibroblastoma with so-called amianthoid fibers: A report of two cases with a review of the literature. Pathology International, 48(4), 307–312.CrossRefGoogle Scholar
  12. Kandemir, N. O., Barut, F., Ekinci, T., Karagülle, C., & Ozdamar, S. O. (2010). Intranodal palisaded myofibroblastoma (intranodal hemorrhagic spindle cell tumor with amianthoid fibers): A case report and literature review. Diagnostic Pathology, 5, 12.CrossRefGoogle Scholar
  13. Karabulut, Y. Y., Kara, T., & Berkeşoğlu, M. (2016). Intranodal palisaded myofibroblastoma – A rare case report and literature review. APMIS, 124(10), 905–910.CrossRefGoogle Scholar
  14. Karvouni, H., Yiallourou, A. I., Kyriazi, M., Stafyla, V., Smyrniotis, V., & Kondi-Pafiti, A. (2010). Intranodal palisaded myofibroblastoma: A case report. Cases Journal, 3, 45.CrossRefGoogle Scholar
  15. Kleist, B., Poetsch, M., & Schmoll, J. (2003). Intranodal palisaded myofibroblastoma with overexpression of cyclin D1. Archives of Pathology & Laboratory Medicine, 127(8), 1040–1043.Google Scholar
  16. Koseoglu, R. D., Ozkan, N., Filiz, N. O., Kayaoglu, H. A., Aydin, M., Culha, E. N., & Ersoy, O. F. (2009). Intranodal palisaded myofibroblastoma; a case report and review of the literature. Pathology & Oncology Research, 15(2), 297–300.CrossRefGoogle Scholar
  17. Laskin, W. B., Lasota, J., Fetsch, J. F., Felisiak-Golabek, A., Wang, Z. F., & Miettinen, M. (2015). Intranodal palisaded myofibroblastoma: Another mesenchymal neoplasm with CTNNB1 (beta-catenin gene) mutations: Clinicopathologic, immunohistochemical, and molecular genetic study of 18 cases. American Journal of Surgical Pathology, 39(2), 197–205.CrossRefGoogle Scholar
  18. Loizou, P., Evgeniou, E., Scott-Young, N., & Orlando, A. (2013). Intranodal palisaded myofibroblastoma presenting as lymphadenopathy of the groin. BMJ Case Reports, 2013 Jan 11. https://doi.org/10.1136/bcr-2012-006374
  19. Sagar, J., Vargiamidou, A., & Manikkapurath, H. (2011). Intranodal palisaded myofibroblastoma originating from retroperitoneum: An unusual origin. BMC Clinical Pathology, 11, 7.CrossRefGoogle Scholar
  20. Skagias, L., Vasou, O., Kondi-Pafiti, A., & Politi, E. (2010). Imprint cytology of intranodal palisaded myofibroblastoma. Diagnostic Cytopathology, 38(4), 272–273.PubMedGoogle Scholar
  21. Sood, N. (2016). Diagnostic clues for FNA diagnosis of intranodal palisaded myofibroblastoma, a rare benign lesion, an introspective case report. Diagnostic Cytopathology, 44(4), 317–323.CrossRefGoogle Scholar
  22. Thiryayi, S. A., Andrews, B., Hall, G. L., & Chaudhry, I. H. (2011). Intranodal palisaded myofibroblastoma - an unusual entity. Journal of Clinical Pathology, 64(4), 370–372.CrossRefGoogle Scholar
  23. Verset, L., Shumelinsky, F., de Wind, R., Demetter, P., & De Saint Aubain, N. (2019). Spindle cells in aspiration material from an inguinal adenopathy: Possibly a sheep in wolf’s clothing! Histopathology, 2019 Mar 12.  https://doi.org/10.1111/his.13859.
  24. Yim, I. H., Will, M. B., Dhaliwal, C., Salter, D. M., & Walker, W. S. (2016). Intranodal palisaded myofibroblastoma masquerading as N2 non-small cell lung carcinoma. Annals of Thoracic Surgery, 102(1), e47–e48.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Taro Mori
    • 1
  • Yuichi Yamada
    • 1
  • Masanori Hisaoka
    • 2
  • Yoshinao Oda
    • 1
    Email author
  1. 1.Department of Anatomic Pathology, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan
  2. 2.Department of Pathology and Oncology, School of MedicineUniversity of Occupational and Environmental HealthKitakyushuJapan