Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Desmoplastic Fibroblastoma

  • Omar Habeeb
  • Steven D. BillingsEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_5375-1



Desmoplastic fibroblastoma represents a well-circumscribed, benign soft tissue tumor. It is composed of a hypocellular proliferation of medium to large-sized, spindled to stellate cells, which are embedded in a hypovascular, collagenous to fibromyxoid stroma (Evans 1995; Miettinen and Fetsch 1998).

Clinical Features

Desmoplastic fibroblastoma typically affects those in middle age (40s–60s), with a male predominance (2–4:1). With a predilection for the upper extremity (shoulder, upper arm, forearm) over the lower extremity, it classically presents as a slow-growing, firm, mobile, rarely painful lesion. Based in the deep subcutaneous tissue, fascia, or skeletal muscle, desmoplastic fibroblastoma is benign, with no recurrence or metastasis (Miettinen and Fetsch 1998).


Most cases range between 1 and 4 cm in size. With a well-circumscribed appearance, desmoplastic fibroblastoma displays a firm, homogeneous, white to pale gray cut surface.


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References and Further Reading

  1. Bernal, K., Nelson, M., Neff, J. R., Nielsen, S. M., & Bridge, J. A. (2004). Translocation (2;11)(q31;q12) is recurrent in collagenous fibroma (desmoplastic fibroblastoma). Cancer Genetics and Cytogenetics, 149(2), 161–163.CrossRefGoogle Scholar
  2. Evans, H. L. (1995). Desmoplastic fibroblastoma: A report of seven cases. The American Journal of Surgical Pathology, 19(9), 1077–1081.CrossRefGoogle Scholar
  3. Kato, I., Yoshida, A., Ikegami, M., Okuma, T., Tonooka, A., Horiguchi, S., Funata, N., Kawai, A., Goto, T., Hishima, T., Aoki, I., & Motoi, T. (2016). FOSL1 immunohistochemistry clarifies the distinction between desmoplastic fibroblastoma and fibroma of tendon sheath. Histopathology, 69(6), 1012–1020.CrossRefGoogle Scholar
  4. Macchia, G., Trombetta, D., Möller, E., Mertens, F., Storlazzi, C. T., Debiec-Rychter, M., Sciot, R., & Nord, K. H. (2012). FOSL1 as a candidate target gene for 11q12 rearrangements in desmoplastic fibroblastoma. Laboratory Investigation, 92(5), 735–743.CrossRefGoogle Scholar
  5. Maghari, A., Ma, N., Aisner, S., Benevenia, J., & Hameed, M. (2009). Collagenous fibroma (desmoplastic fibroblastoma) with a new translocation involving 11q12: A case report. Cancer Genetics and Cytogenetics, 192(2), 73–75.CrossRefGoogle Scholar
  6. Miettinen, M., & Fetsch, J. F. (1998). Collagenous fibroma (desmoplastic fibroblastoma): A clinicopathologic analysis of 63 cases of a distinctive soft tissue lesion with stellate-shaped fibroblasts. Human Pathology, 29(7), 676–682.CrossRefGoogle Scholar
  7. Nishio, J., Iwasaki, H., Yano, S., & Naito, M. (2013). Collagenous fibroma (desmoplastic fibroblastoma) with trisomy 8 as the sole cytogenetic abnormality. Anticancer Research, 33(8), 3259–3262.PubMedGoogle Scholar
  8. Sciot, R., Samson, I., van den Berghe, H., Van Damme, B., & Dal Cin, P. (1999). Collagenous fibroma (desmoplastic fibroblastoma): Genetic link with fibroma of tendon sheath? Modern Pathology, 12(6), 565–568.PubMedGoogle Scholar

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Authors and Affiliations

  1. 1.Department of PathologyCleveland ClinicClevelandUSA