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Desmoplastic fibroblastoma typically affects those in middle age (40s–60s), with a male predominance (2–4:1). With a predilection for the upper extremity (shoulder, upper arm, forearm) over the lower extremity, it classically presents as a slow-growing, firm, mobile, rarely painful lesion. Based in the deep subcutaneous tissue, fascia, or skeletal muscle, desmoplastic fibroblastoma is benign, with no recurrence or metastasis (Miettinen and Fetsch 1998).
Most cases range between 1 and 4 cm in size. With a well-circumscribed appearance, desmoplastic fibroblastoma displays a firm, homogeneous, white to pale gray cut surface.
References and Further Reading
- Kato, I., Yoshida, A., Ikegami, M., Okuma, T., Tonooka, A., Horiguchi, S., Funata, N., Kawai, A., Goto, T., Hishima, T., Aoki, I., & Motoi, T. (2016). FOSL1 immunohistochemistry clarifies the distinction between desmoplastic fibroblastoma and fibroma of tendon sheath. Histopathology, 69(6), 1012–1020.CrossRefGoogle Scholar