Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Chondroid Lipoma

  • Alessandro FranchiEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_5365-1

Definition

Chondroid lipoma (CL) is a benign adipocytic tumor combining adipocytic and cartilaginous features (Meis and Enzinger 1993; Thway et al. 2012).

Clinical Features

  • Incidence

    CL is extremely rare, with only few small series and single cases reported.

  • Age

    It occurs over a wide age range, but predominately in young adults, with a median of 30 years (Thway et al. 2012).

  • Sex

    CL arises more frequently in women (Thway et al. 2012).

  • Site

    Tumors are more frequently deep-seated and involve the proximal extremities and limb girdles. CL may also occur in the head and neck, particularly in the oral cavity (Meis and Enzinger 1993; Thway et al. 2012).

  • Treatment

    Surgical excision is the primary treatment for eradication of the tumor.

  • Outcome

    CL is benign and complete surgical removal is curative.

Macroscopy

CL appears as a well-circumscribed mass, measuring in average 4–5 cm (range 2–11), with a lobulated yellow cut surface and gelatinous tan-gray areas (Thway et al. 2012). Hemorrhage can...

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References

  1. Ballaux, F., Debiec-Rychter, M., De Wever, I., & Sciot, R. (2004). Chondroid lipoma is characterized by t(11;16)(q13;p12–13). Virchows Archiv, 444(2), 208–210.CrossRefGoogle Scholar
  2. Flucke, U., Tops, B. B., de Saint Aubain Somerhausen, N., Bras, J., Creytens, D. H., Küsters, B., Groenen, P. J., Verdijk, M. A., Suurmeijer, A. J., & Mentzel, T. (2013). Presence of C11orf95-MKL2 fusion is a consistent finding in chondroid lipomas: a study of eight cases. Histopathology, 62, 925–930.CrossRefGoogle Scholar
  3. Gisselsson, D., Domanski, H. A., Höglund, M., Carlén, B., Mertens, F., Willén, H., & Mandahl, N. (1999). Unique cytological features and chromosome aberrations in chondroid lipoma: A case report based on fine-needle aspiration cytology, histopathology, electron microscopy, chromosome banding, and molecular cytogenetics. The American Journal of Surgical Pathology, 23, 1300–1304.CrossRefGoogle Scholar
  4. Huang, D., Sumegi, J., Dal Cin, P., Reith, J. D., Yasuda, T., Nelson, M., Muirhead, D., & Bridge, J. A. (2010). C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma. Genes, Chromosomes & Cancer, 49, 810–818.Google Scholar
  5. Meis, J. M., & Enzinger, F. M. (1993). Chondroid lipoma: a unique tumor simulating liposarcoma and myxoid chondrosarcoma. The American Journal of Surgical Pathology, 17, 1103–1112.CrossRefGoogle Scholar
  6. Thway, K., Flora, R. S., & Fisher, C. (2012). Chondroid lipoma: An update and review. Annals of Diagnostic Pathology, 16, 230–234.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Translational Research and of New Technologies in Medicine and SurgeryUniversity of PisaPisaItaly