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Cellular Angiofibroma

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 20 Accesses

Definition

Well-circumscribed benign neoplasm of superficial soft tissue composed of short, intersecting fascicles of bland spindle cells and a prominent vascular component that is a member of the family of benign mesenchymal tumors showing loss of RB1

Clinical Features

  • Incidence

    Cellular angiofibroma is uncommon.

  • Age

    This tumor occurs over a wide age range. In women, it most commonly occurs in the fifth to sixth decade whereas in men, it occurs most commonly in the seventh decade.

  • Sex

    Cellular angiofibroma occurs in both men and women with equal frequency.

  • Site

    In women, the most common site is superficial soft tissue of the vulva and vagina. The inguinoscrotal region is the most common site in men. Extra-genital tumors have been described.

  • Treatment

    Local conservative excision with negative margins is adequate treatment.

  • Outcome

    These tumors are benign and local recurrence is infrequent. Tumors described as having atypia or “sarcomatous transformation” have (so far) had a benign...

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References and Further Reading

  • Chen, E., & Fletcher, C. D. (2010). Cellular angiofibroma with atypia or sarcomatous transformation: Clinicopathologic analysis of 13 cases. The American Journal of Surgical Pathology, 34(5), 707–714.

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  • Chen, B. J., Mariño-Enríquez, A., Fletcher, C. D., et al. (2012). Loss of retinoblastoma protein expression in spindle cell/pleomorphic lipomas and cytogenetically related tumors: An immunohistochemical study with diagnostic implications. The American Journal of Surgical Pathology, 36(8), 1119–1128.

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  • Flucke, U., van Krieken, J. H., & Mentzel, T. (2011). Cellular angiofibroma: Analysis of 25 cases emphasizing its relationship to spindle cell lipoma and mammary-type myofibroblastoma. Modern Pathology, 24(1), 82–89.

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  • Iwasa, Y., & Fletcher, C. D. (2004). Cellular angiofibroma: Clinicopathologic and immunohistochemical analysis of 51 cases. The American Journal of Surgical Pathology, 28(11), 1426–1435.

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  • Kandil, D. H., Kida, M., Laub, D. R., et al. (2009). Sarcomatous transformation in a cellular angiofibroma: A case report. Journal of Clinical Pathology, 62(10), 945–947.

    Article  CAS  Google Scholar 

  • Maggiani, F., Debiec-Rychter, M., Vanbockrijck, M., et al. (2007). Cellular angiofibroma: Another mesenchymal tumour with 13q14 involvement, suggesting a link with spindle cell lipoma and (extra)-mammary myofibroblastoma. Histopathology, 51(3), 410–412.

    Article  CAS  Google Scholar 

  • McCluggage, W. G., Ganesan, R., Hirschowitz, L., et al. (2004). Cellular angiofibroma and related fibromatous lesions of the vulva: Report of a series of cases with a morphological spectrum wider than previously described. Histopathology, 45(4), 360–368.

    Article  CAS  Google Scholar 

  • Panagopoulos, I., Gorunova, L., Bjerkehagen, B., et al. (2017). Loss of chromosome 13 material in cellular angiofibromas indicates pathogenetic similarity with spindle cell lipomas. Diagnostic Pathology, 12(1), 17.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Women’s and Perinatal Pathology, Department of Pathology, Brigham Women’s Hospital, Boston, MA, USA

    Marisa R. Nucci

Authors
  1. Marisa R. Nucci
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Corresponding author

Correspondence to Marisa R. Nucci .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Nucci, M.R. (2020). Cellular Angiofibroma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5363-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_5363-1

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  • Accepted:

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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