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Well-circumscribed benign neoplasm of superficial soft tissue composed of short, intersecting fascicles of bland spindle cells and a prominent vascular component that is a member of the family of benign mesenchymal tumors showing loss of RB1
Cellular angiofibroma is uncommon.
This tumor occurs over a wide age range. In women, it most commonly occurs in the fifth to sixth decade whereas in men, it occurs most commonly in the seventh decade.
Cellular angiofibroma occurs in both men and women with equal frequency.
In women, the most common site is superficial soft tissue of the vulva and vagina. The inguinoscrotal region is the most common site in men. Extra-genital tumors have been described.
Local conservative excision with negative margins is adequate treatment.
These tumors are benign and local recurrence is infrequent. Tumors described as having atypia or “sarcomatous transformation” have (so far) had a benign...
References and Further Reading
- Chen, B. J., Mariño-Enríquez, A., Fletcher, C. D., et al. (2012). Loss of retinoblastoma protein expression in spindle cell/pleomorphic lipomas and cytogenetically related tumors: An immunohistochemical study with diagnostic implications. The American Journal of Surgical Pathology, 36(8), 1119–1128.CrossRefGoogle Scholar