Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Cellular Angiofibroma

  • Marisa R. NucciEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_5363-1


Well-circumscribed benign neoplasm of superficial soft tissue composed of short, intersecting fascicles of bland spindle cells and a prominent vascular component that is a member of the family of benign mesenchymal tumors showing loss of RB1

Clinical Features

  • Incidence

    Cellular angiofibroma is uncommon.

  • Age

    This tumor occurs over a wide age range. In women, it most commonly occurs in the fifth to sixth decade whereas in men, it occurs most commonly in the seventh decade.

  • Sex

    Cellular angiofibroma occurs in both men and women with equal frequency.

  • Site

    In women, the most common site is superficial soft tissue of the vulva and vagina. The inguinoscrotal region is the most common site in men. Extra-genital tumors have been described.

  • Treatment

    Local conservative excision with negative margins is adequate treatment.

  • Outcome

    These tumors are benign and local recurrence is infrequent. Tumors described as having atypia or “sarcomatous transformation” have (so far) had a benign...

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References and Further Reading

  1. Chen, E., & Fletcher, C. D. (2010). Cellular angiofibroma with atypia or sarcomatous transformation: Clinicopathologic analysis of 13 cases. The American Journal of Surgical Pathology, 34(5), 707–714.CrossRefGoogle Scholar
  2. Chen, B. J., Mariño-Enríquez, A., Fletcher, C. D., et al. (2012). Loss of retinoblastoma protein expression in spindle cell/pleomorphic lipomas and cytogenetically related tumors: An immunohistochemical study with diagnostic implications. The American Journal of Surgical Pathology, 36(8), 1119–1128.CrossRefGoogle Scholar
  3. Flucke, U., van Krieken, J. H., & Mentzel, T. (2011). Cellular angiofibroma: Analysis of 25 cases emphasizing its relationship to spindle cell lipoma and mammary-type myofibroblastoma. Modern Pathology, 24(1), 82–89.CrossRefGoogle Scholar
  4. Iwasa, Y., & Fletcher, C. D. (2004). Cellular angiofibroma: Clinicopathologic and immunohistochemical analysis of 51 cases. The American Journal of Surgical Pathology, 28(11), 1426–1435.CrossRefGoogle Scholar
  5. Kandil, D. H., Kida, M., Laub, D. R., et al. (2009). Sarcomatous transformation in a cellular angiofibroma: A case report. Journal of Clinical Pathology, 62(10), 945–947.CrossRefGoogle Scholar
  6. Maggiani, F., Debiec-Rychter, M., Vanbockrijck, M., et al. (2007). Cellular angiofibroma: Another mesenchymal tumour with 13q14 involvement, suggesting a link with spindle cell lipoma and (extra)-mammary myofibroblastoma. Histopathology, 51(3), 410–412.CrossRefGoogle Scholar
  7. McCluggage, W. G., Ganesan, R., Hirschowitz, L., et al. (2004). Cellular angiofibroma and related fibromatous lesions of the vulva: Report of a series of cases with a morphological spectrum wider than previously described. Histopathology, 45(4), 360–368.CrossRefGoogle Scholar
  8. Panagopoulos, I., Gorunova, L., Bjerkehagen, B., et al. (2017). Loss of chromosome 13 material in cellular angiofibromas indicates pathogenetic similarity with spindle cell lipomas. Diagnostic Pathology, 12(1), 17.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Division of Women’s and Perinatal Pathology, Department of PathologyBrigham Women’s HospitalBostonUSA