Penile Clear Cell Carcinoma
Penile clear cell carcinoma (PCCC) is an aggressive human papillomavirus (HPV)-related tumor predominantly composed of clear cells.
This very unusual tumor shows regional metastases and a tumor mortality exceeding 20% of the cases (Sanchez et al. 2016). PCCC occurs as large, irregular masses on the foreskin or glans.
PCCC has a predominant nesting growth pattern with comedonecrosis in central part of nests and comedo-like necrosis; there are clear cell features in cells with irregular or eccentric nuclei. The presence of HPV is diffused throughout the tumor. Intraepithelial neoplasia with warty or basaloid features can be found.
Warty Carcinoma with Prominent Clear Cells
The main differential feature is the papillary pattern of growth in warty carcinoma that is not observed in PCCC, where the growth pattern is in solid sheets or nests.
The presence of nesting growth pattern is the overlapping feature among these entities. In basaloid carcinoma, cells are small, uniform, and basaloid, but the late feature (basaloid differentiation) is at least focal in PCCC.
References and Further Reading
- Sanchez, D. F., Rodriguez, I. M., Piris, A., Cañete, S., Lezcano, C., Velazquez, E. F., Fernandez-Nestosa, M. J., Mendez-Pena, J. E., Hoang, M. P., & Cubilla, A. L. (2016). Clear cell carcinoma of the penis: An HPV-related variant of squamous cell carcinoma: A report of 3 cases. The American Journal of Surgical Pathology, 40(7), 917–922.CrossRefGoogle Scholar