Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Benign Fibrous Histiocytoma

  • Alessandro FranchiEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_4785-1

Synonyms

Definition

Benign fibrous histiocytoma is a cutaneous tumor with predominantly dermal involvement, mainly composed of cells with fibro-histiocytic differentiation.

Clinical Features

  • Incidence

    In general, BFH is a very common neoplasm, but involvement of the scrotum and the penis is exceedingly rare (Dehner and Smith 1970; Kinoshita et al. 1985; Huan et al. 2003).

  • Age

    It may occur at any age, but it is most common in adults.

  • Treatment

    The treatment of choice is surgical excision.

  • Outcome

    Complete surgical excision is usually curative.

Macroscopy

BFH appears as a firm, non-encapsulated lesion of the dermis, with white to yellow cut surface. Cystic changes and hemorrhage may be present.

Microscopy

Histologically, there is a dermal-centered proliferation of bland spindle fibroblast-like cells and of histiocytoid cells, entrapping thick collagen fibers, especially at the periphery of the tumor (Fig. 1). The overlying epidermis is hyperplastic...
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References and Further Reading

  1. Dehner, L. P., & Smith, B. H. (1970). Soft tissue tumors of the penis. A clinicopathologic study of 46 cases. Cancer, 25, 1431–1447.CrossRefGoogle Scholar
  2. Huan, Y., Vapnek, J., & Unger, P. D. (2003). Atypical fibrous histiocytoma of the scrotum. Annals of Diagnostic Pathology, 7, 370–373.CrossRefGoogle Scholar
  3. Kinoshita, H., Okada, K., Nagata, Y., & Kawamura, N. (1985). Fibrous histiocytoma of penis. Urology, 25, 544–546.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Translational Research and of New Technologies in Medicine and SurgeryUniversity of PisaPisaItaly