Skip to main content
SpringerLink
Log in
Book cover

Encyclopedia of Pathology pp 1–4Cite as

Solid Papillary Carcinoma

  • Living reference work entry
  • First Online:

  • 79 Accesses

Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Solid Papillary Neuroendocrine Breast Carcinoma

Definition

Solid papillary carcinoma (SPC) is described in the 2012 WHO classification within the group of the intraductal papillary lesions and is defined as a variant of papillary carcinoma characterized by multiple solid nodules of neoplastic cells arranged around multiple fibrovascular spaces. Despite the lack of the external myoepithelial layer, these lesions are currently considered as noninvasive (Lakhani et al. 2012). However, cases of true invasive SPC exist.

Clinical Features

  • Incidence

    SPC is a rare entity, accounting for 1–2% of breast carcinomas (BCs) (Otsuki et al. 2007).

  • Age

    It usually affects women in the seventh decade, with a mean age of 73.2 years (Maluf and Koerner 1995).

  • Sex

    It is more frequently observed in female patients, but it has been sporadically described in men (Nassar et al. 2006).

  • Side

    SPC is typically unifocal and localized in the central region of the breast (Guo et al. 2016), although a single...

This is a preview of subscription content, log in via an institution.

References and Further Reading

  • Burt, M., Madan, R., & Fan, F. (2016). Metastatic gastrinoma in the breast mimicking primary solid papillary carcinoma. Human Pathology, 56, 143–146.

    Article  Google Scholar 

  • Cui, X., & Wei, S. (2015). Composite encapsulated papillary carcinoma and solid papillary carcinoma. Pathology International, 65, 133–137.

    Article  Google Scholar 

  • Duprez, R., Wilkerson, P. M., Lacroix-Triki, M., Lambros, M. B., MacKay, A., A’Hern, R., Gauthier, A., et al. (2012). Immunophenotypic and genomic characterization of papillary carcinomas of the breast. The Journal of Pathology, 226, 427–441.

    Article  CAS  Google Scholar 

  • Guo, S., Wang, Y., Rohr, J., Fan, C., Li, Q., Li, X., & Wang, Z. (2016). Solid papillary carcinoma of the breast: A special entity needs to be distinguished from conventional invasive carcinoma avoiding over-treatment. The Breast, 26, 67–72.

    Article  Google Scholar 

  • Lakhani, S. R., Ellis, I. O., Schnitt, S. J., Tan, P. H., van de Vijver, M. J. (2012). WHO classification of tumours of the breast. World Health Organization classification of tumours. Lyon, IARC press. ISBN-10: 9283224337.

    Google Scholar 

  • Maluf, H. M., & Koerner, F. C. (1995). Solid papillary carcinoma of the breast. A form of intraductal carcinoma with endocrine differentiation frequently associated with mucinous carcinoma. The American Journal of Surgical Pathology, 19, 1237–1244.

    Article  CAS  Google Scholar 

  • Nassar, H., Qureshi, H., Adsay, N. V., Volkanadsay, N., & Visscher, D. (2006). Clinicopathologic analysis of solid papillary carcinoma of the breast and associated invasive carcinomas. The American Journal of Surgical Pathology, 30, 501–507.

    Article  Google Scholar 

  • Ni, Y. B., & Tse, G. M. (2016). Pathological criteria and practical issues in papillary lesions of the breast – A review. Histopathology, 68, 22–32.

    Article  Google Scholar 

  • Otsuki, Y., Yamada, M., Shimizu, S., Suwa, K., Yoshida, M., Tanioka, F., Ogawa, H., et al. (2007). Solid-papillary carcinoma of the breast: Clinicopathological study of 20 cases. Pathology International, 57, 421–429.

    Article  Google Scholar 

  • Piscuoglio, S., Ng, C. K. Y., Martelotto, L. G., Eberle, C. A., Cowell, C. F., Natrajan, R., Bidard, F. C., et al. (2014). Integrative genomic and transcriptomic characterization of papillary carcinomas of the breast. Molecular Oncology, 8, 1588–1602.

    Article  CAS  Google Scholar 

  • Rabban, J. T., Koerner, F. C., & Lerwill, M. F. (2006). Solid papillary ductal carcinoma in situ versus usual ductal hyperplasia in the breast: A potentially difficult distinction resolved by cytokeratin 5/6. Human Pathology, 37, 787–793.

    Article  CAS  Google Scholar 

  • Tan, B. Y., Thike, A. A., Ellis, I. O., & Tan, P. H. (2016). Clinicopathologic characteristics of solid papillary carcinoma of the breast. American Journal of Surgical Pathology, 40, 1334–1342.

    Article  Google Scholar 

  • Turashvili, G., Brogi, E., Morrow, M., Hudis, C., Dickler, M., Norton, L., & Wen, H. Y. (2017). The 21-gene recurrence score in special histologic subtypes of breast cancer with favorable prognosis. Breast Cancer Research and Treatment, 165, 65–76.

    Article  CAS  Google Scholar 

  • Wei, S. (2016). Papillary lesions of the breast: An update. Archives of Pathology & Laboratory Medicine, 140, 628–643.

    Article  Google Scholar 

  • Yoshimura, N., Murakami, S., Kaneko, M., Sakatani, A., Hirabayashi, N., & Takiyama, W. (2013). Synchronous bilateral solid papillary carcinomas of the breast. Case Reports in Surgery, 2013, 812129.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medical Sciences, University of Torino, Torino, Italy

    Elena Vissio, Caterina Marchiò & Anna Sapino

  2. Candiolo Cancer Institute FPO-IRCCS, Unit of Pathology, Candiolo, Italy

    Caterina Marchiò & Anna Sapino

Authors
  1. Elena Vissio
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Caterina Marchiò
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Anna Sapino
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Anna Sapino .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Vissio, E., Marchiò, C., Sapino, A. (2019). Solid Papillary Carcinoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4760-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4760-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation