Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Invasive Oncocytic Carcinoma

  • Dario de Biase
  • Moira Ragazzi
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_4759-1

Synonyms

Definition

Invasive oncocytic carcinoma (OC) is a “special type” of breast carcinoma that is composed of at least 70% of cells with oncocytic features (so-called oncocytes) on both morphologic and immunophenotypic grounds (Lakhani et al. 2012).

Oncocyte is a Greek term, first applied to salivary glands by Hamperl (1931) in 1931, which means “swollen cell.” Under light microscope, oncocytes are characterized by abundant granular eosinophilic cytoplasm due to a high content of mitochondria, demonstrable at ultrastructural level (Roth et al. 1962). By definition, mitochondria must occupy at least 60% of the total cytoplasmic volume (Ghadially 1985) and confer an intense cytoplasmic granular positivity for anti-mitochondrion antibody (Damiani et al. 1998; Ragazzi et al. 2011). Namely, a carcinoma can be classified as oncocytic if it shows a strong cytoplasmic positivity for anti-mitochondrion antibody in at least 70% of tumor cells.

Clinical Features

  • Incidence

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References and Further Reading

  1. Bhargava, R., Florea, A. V., Pelmus, M., Jones, M. W., Bonaventura, M., Wald, A., & Nikiforova, M. (2017). Breast tumor resembling tall cell variant of papillary thyroid carcinoma: A solid papillary neoplasm with characteristic immunohistochemical profile and few recurrent mutations. American Journal of Clinical Pathology, 147, 399–410.CrossRefPubMedPubMedCentralGoogle Scholar
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  3. Damiani, S., Eusebi, V., Losi, L., D’Adda, T., & Rosai, J. (1998). Oncocytic carcinoma (malignant oncocytoma) of the breast. American Journal of Surgical Pathology, 22, 221–230.CrossRefGoogle Scholar
  4. Eusebi, V., Damiani, S., Ellis, I. O., Azzopardi, J. G., & Rosai, J. (2003). Breast tumor resembling the tall cell variant of papillary thyroid carcinoma: Report of 5 cases. American Journal of Surgical Pathology, 27, 1114–1118.CrossRefPubMedPubMedCentralGoogle Scholar
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  9. Hamperl, H. (1931). Beiträge zur normalen und pathologischen Histologie menschlieher Speicheldriisen. Zeitschrift für Mikroskopisch-Anatomische Forschung, 27, 1–55.Google Scholar
  10. Itagaki, H., Yamamoto, T., Hiroi, A., Kawanishi, K., Noguchi, E., Ohchi, T., Kamio, T., Kameoka, S., Oda, H., & Nagashima, Y. (2017). Synchronous and bilateral oncocytic carcinoma of the breast: A case report and review of the literature. Oncology Letters, 13, 1714–1718.CrossRefPubMedPubMedCentralGoogle Scholar
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Authors and Affiliations

  1. 1.Department of Pharmacy and BiotechnologyUniversity of BolognaBolognaItaly
  2. 2.Department of Oncology and Advanced Technologies, Operative Unit of PathologyAzienda USL-IRCCSReggio EmiliaItaly