Pleomorphic Lobular Carcinoma
Pleomorphic lobular carcinoma (PLC) is currently defined by the World Health Organization (Lakhani et al. 2012) as a rare variant of invasive lobular carcinoma (ILC), exhibiting marked nuclear pleomorphism and cellular atypia. It may be associated with pleomorphic lobular carcinoma in situ (PLCIS), which refers to a lobular carcinoma in situ (LCIS) with high-grade cytological features. PLC was first documented by Martinez and Azzopardi (1979) then subsequently reported by Dixon (Dixon et al. 1982) and formally described by Page and Anderson (1987). Further characterization was provided in 1992 by Eusebi (Eusebi et al. 1992) and Weidner (Weidner and Semple 1992), who emphasized its aggressive behavior and poor clinical outcome.
Incidence: The exact incidence of PLC is unknown because of its rare occurrence and the lack of large case studies addressing this issue. Based on current literature, PLC represents approximately 10–15% of ILC, thus accounting for...
References and Further Reading
- Lakhani, S., Ellis, I., et al. (2012). WHO classification of Tumours of the breast (4th ed.). Lyon: IARC Press.Google Scholar
- Liu, Y. L., Choi, C., et al. (2017). Invasive lobular breast carcinoma: Pleomorphic versus classical subtype, associations and prognosis. Clinical Breast Cancer, 8209(16), 30558–30554.Google Scholar
- Page, D. L., & Anderson, T. J. (1987). Diagnostic histopathology of the breast. Edinburgh: Churchill Livingstone.Google Scholar