Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Invasive Micropapillary Carcinoma

Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_4718-1

Synonyms

Definition

Invasive micropapillary carcinoma (IMPC) is a special type of invasive breast carcinoma (IBC) characterized by cancer cells with eosinophilic or granular cytoplasm, forming morule-like clusters, surrounded by clear stromal spaces. Tumor cells have characteristic reverse polarity, also known as an “inside-out” growth pattern: the apical pole of tumor cells faces the empty stromal spaces.

Clinical Features

  • Incidence: Pure IMPC is a rare subtype of invasive breast cancer, accounting in its pure form for 0.9–2% of IBCs. The reported incidence of IBC with a micropapillary component is up to 8%.

  • Age: The reported median age of IMPC is from 48 to 62 years, consistent with that of patients with estrogen receptor (ER) positive IBC.

  • Sex: IMPC usually affects women, but single cases of male IMPC had been reported. In studies on male breast cancer, the reported incidence of IBC with micropapillary features varies between 0% and 11%.

  • Site: No specific...

This is a preview of subscription content, log in to check access.

References and Further Reading

  1. Chen, A. C., Paulino, A. C., Schwartz, M. R., Rodriguez, A. A., Bass, B. L., Chang, J. C., & Teh, B. S. (2014). Population-based comparison of prognostic factors in invasive micropapillary and invasive ductal carcinoma of the breast. British Journal of Cancer, 111, 619–622.CrossRefGoogle Scholar
  2. Fisher, E. R., Palekar, A. S., Redmond, C., Barton, B., & Fisher, B. (1980). Pathologic findings from the National Surgical Adjuvant Breast Project (protocol no. 4). VI. Invasive papillary cancer. American Journal of Clinical Pathology, 73, 313–322.CrossRefGoogle Scholar
  3. Gruel, N., Benhamo, V., Bhalshankar, J., Popova, T., Freneaux, P., Arnould, L., Mariani, O., Stern, M. H., Raynal, V., Sastre-Garau, X., Rouzier, R., Delattre, O., & Vincent-Salomon, A. (2014). Polarity gene alterations in pure invasive micropapillary carcinomas of the breast. Breast Cancer Research, 16, R46.  https://doi.org/10.1186/bcr3653
  4. Lee, A. H., Paish, E. C., Marchio, C., Sapino, A., Schmitt, F. C., Ellis, I. O., & Reis-Filho, J. S. (2007). The expression of Wilms’ tumour-1 and Ca125 in invasive micropapillary carcinoma of the breast. Histopathology, 51(6), 824–828.CrossRefGoogle Scholar
  5. Li, S., Yang, C., Zhai, L., Zhang, W., Yu, J., Gu, F., Lang, R., Fan, Y., Gong, M., Zhang, X., & Fu, L. (2012). Deep sequencing reveals small RNA characterization of invasive micropapillary carcinomas of the breast. Breast Cancer Research and Treatment, 136(1), 77–87.CrossRefGoogle Scholar
  6. Marchiò, C., Iravani, M., Natrajan, R., Lambros, M. B., Savage, K., Tamber, N., Fenwick, K., Mackay, A., Senetta, R., Di Palma, S., Schmitt, F. C., Bussolati, G., Ellis, I. O., Ashworth, A., Sapino, A., & Reis-Filho, J. S. (2008). Genomic and immunophenotypical characterization of pure micropapillary carcinomas of the breast. The Journal of Pathology, 215, 398–410.CrossRefGoogle Scholar
  7. Marchiò, C., Iravani, M., Natrajan, R., Lambros, M. B., Geyer, F. C., Savage, K., Parry, S., Tamber, N., Fenwick, K., Mackay, A., Schmitt, F. C., Bussolati, G., Ellis, I., Ashworth, A., Sapino, A., & Reis-Filho, J. S. (2009). Mixed micropapillary-ductal carcinomas of the breast: A genomic and immunohistochemical analysis of morphologically distinct components. The Journal of Pathology, 218(3), 301–315.CrossRefGoogle Scholar
  8. Natrajan, R., Wilkerson, P. M., Marchiò, C., Piscuoglio, S., Ng, C. K., Wai, P., Lambros, M. B., Samartzis, E. P., Dedes, K. J., Frankum, J., Bajrami, I., Kopec, A., Mackay, A., A’Hern, R., Fenwick, K., Kozarewa, I., Hakas, J., Mitsopoulos, C., Hardisson, D., Lord, C. J., Kumar-Sinha, C., Ashworth, A., Weigelt, B., Sapino, A., Chinnaiyan, A. M., Maher, C. A., & Reis-Filho, J. S. (2014). Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast. The Journal of Pathology, 232(5), 553–565.CrossRefGoogle Scholar
  9. Peterse, J. L. (1993). Breast carcinomas with an unexpected inside-out growth pattern: rotation of polarization associated with angioinvasion. (Abstract). Pathology Research and Practice, 189, 780.Google Scholar
  10. Siriaunkgul, S., & Tavassoli, F. A. (1993). Invasive micropapillary carcinoma of the breast. Modern Pathology, 6, 660–662.PubMedGoogle Scholar
  11. Wang, X. X., Liu, B. B., Wu, X., Su, D., Zhu, Z., & Fu, L. (2015). Loss of leucine zipper putative tumor suppressor 1 (LZTS1) expression contributes to lymph node metastasis of breast invasive micropapillary carcinoma. Pathology Oncology Research: POR, 21(4), 1021–1026.CrossRefGoogle Scholar
  12. Weigelt, B., Horlings, H. M., Kreike, B., Hayes, M. M., Hauptmann, M., Wessels, L. F. A., de Jong, D., Van de Vijver, M. J., Van’t Veer, L. J., & Peterse, J. L. (2008). Refinement of breast cancer classification by molecular characterization of histological special types. The Journal of Pathology, 216, 141–150.CrossRefGoogle Scholar
  13. Yi-Ling, Y., Bing-Bing, L., Xinmin, Z., & Li, F. (2016). Invasive micropapillary carcinoma of the breast: An update. Archives of Pathology and Laboratory Medicine, 140, 799–805.CrossRefGoogle Scholar
  14. Yu, J. I., Choi, D. H., Huh, S. J., Cho, E. Y., Kim, K., Chie, E. K., Ha, S. W., Park, I. A., Ahn, S. J., Lee, J. S., Shin, K. H., Kwon, Y., Kim, Y. B., Suh, C. O., Koo, J. S., Kim, J. H., Jeong, B. G., Kim, I. A., Lee, J. H., & Park, W. (2015). Differences in prognostic factors and failure patterns between invasive micropapillary carcinoma and carcinoma with micropapillary component versus invasive ductal carcinoma of the breast: Retrospective Multicenter Case-Control Study (KROG 13-06). Clinical Breast Cancer, 15, 353-361.e351-352.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.2nd Department of PathologySemmelweis University BudapestBudapestHungary