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Encyclopedia of Pathology pp 1–10Cite as

Peripheral T-Cell Lymphoma, Not Otherwise Specified

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Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Lennert lymphoma (Kiel classification); Lymphoepithelioid lymphoma; Peripheral T-cell lymphoma, large cell; Peripheral T-cell lymphoma, pleomorphic medium and large cell; Peripheral T-cell lymphoma, unspecified (WHO 2001); Peripheral T-cell lymphoma, pleomorphic small cell; T-cell lymphoma, NOS

Definition

Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) is a heterogeneous group of mature T-cell lymphomas. It is defined by default for cases not fulfilling the criteria for specifically defined PTCL entities according to the 2017 WHO classification. This category probably encompasses several biological subgroups that are still undefined. Because PTCL, NOS is a diagnosis of exclusion, it requires an expert pathologic review with an exhaustive workup. A recent study highlighted that the diagnosis of PTCL, NOS is challenging and poorly reproducible, with an overall concordance of 63.4% between referral and expert pathologists. Especially, a diagnosis of nodal PTCL...

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References and Further Reading

  • D’Amore, F., Gaulard, P., Trumper, L., Corradini, P., Kim, W. S., Specht, L., Bjerregaard Pedersen, L., Ladetto, M., & on behalf of the ESMO Guidelines Committee. (2015). Peripheral T-cell lymphomas: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Annals of Oncology, 26(Supplement 5), v108–v115.

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  • Jaffe, E. S., Arber, D. A., Campo, E., Lee Harris, N., & Quintanilla-Fend, L. (2016). Haematopathology. In Peripheral T-cell lymphoma, not otherwise specified (2nd ed., pp. 641–657). Elsevier: Philadelphia, PA.

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  • Laurent, C., et al. (2017). Impact of Expert Pathologic review of lymphoma diagnosis: Study of patients from the French Lymphopath Network. Journal of Clinical Oncology, 35(18), 2008–2017.

    Article  Google Scholar 

  • Lemonnier, F., Gaulard, P., & de Leval, L. (2018). New insights in the pathogenesis of T-cell lymphomas. Current Opinion in Oncology, 30(5), 277–284.

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  • Swerdlow, S., Campo, E., Harris, N. L., Jaffe, E. S., Pileri, S. A., Stein, H., Thiele, J., Arber, D., Hasserjian, R., & Le Beau, M. (2017). WHO classification of tumours of haematopoietic and lymphoid tissues. In Peripheral T-cell lymphoma, NOS (Revised 4th ed., pp. 403–407). IARC: Lyon. WHO Classification of Tumours.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pathology, Henri Mondor Hospital, Creteil, France

    Philippe Gaulard

  2. Department of Pathology, Centre Henri Becquerel, Rouen, France

    Fanny Drieux

Authors
  1. Philippe Gaulard
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  2. Fanny Drieux
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Corresponding author

Correspondence to Philippe Gaulard .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Gaulard, P., Drieux, F. (2019). Peripheral T-Cell Lymphoma, Not Otherwise Specified. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_3895-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_3895-1

  • Received:

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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