Peripheral T-Cell Lymphoma, Not Otherwise Specified
Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) is a heterogeneous group of mature T-cell lymphomas. It is defined by default for cases not fulfilling the criteria for specifically defined PTCL entities according to the 2017 WHO classification. This category probably encompasses several biological subgroups that are still undefined. Because PTCL, NOS is a diagnosis of exclusion, it requires an expert pathologic review with an exhaustive workup. A recent study highlighted that the diagnosis of PTCL, NOS is challenging and poorly reproducible, with an overall concordance of 63.4% between referral and expert pathologists. Especially, a diagnosis of nodal PTCL...
References and Further Reading
- D’Amore, F., Gaulard, P., Trumper, L., Corradini, P., Kim, W. S., Specht, L., Bjerregaard Pedersen, L., Ladetto, M., & on behalf of the ESMO Guidelines Committee. (2015). Peripheral T-cell lymphomas: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Annals of Oncology, 26(Supplement 5), v108–v115.CrossRefGoogle Scholar
- Jaffe, E. S., Arber, D. A., Campo, E., Lee Harris, N., & Quintanilla-Fend, L. (2016). Haematopathology. In Peripheral T-cell lymphoma, not otherwise specified (2nd ed., pp. 641–657). Elsevier: Philadelphia, PA.Google Scholar
- Swerdlow, S., Campo, E., Harris, N. L., Jaffe, E. S., Pileri, S. A., Stein, H., Thiele, J., Arber, D., Hasserjian, R., & Le Beau, M. (2017). WHO classification of tumours of haematopoietic and lymphoid tissues. In Peripheral T-cell lymphoma, NOS (Revised 4th ed., pp. 403–407). IARC: Lyon. WHO Classification of Tumours.Google Scholar