Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Angioimmunoblastic T-Cell Lymphoma

  • Laurence de Leval
  • Bettina Bisig
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_3862-1

Synonyms

Definition

Angioimmunoblastic T-cell lymphoma (AITL) is a neoplasm of mature T follicular helper (TFH) cells characterized by systemic disease, a polymorphous infiltrate involving lymph nodes, with a prominent proliferation of high endothelial venules and follicular dendritic cells (Swerdlow et al. 2017).

Clinical Features

  • Incidence

According to a retrospective study published in 2008, AITL represents the second most common form peripheral T-cell lymphoma (PTCL) worldwide, accounting for 18.5% of the cases. The disease is more common in Europe (representing 29% of the cases) than in North America or Asia where its prevalence is estimated to be 16% and 18% of the cases, respectively. According to recent publications reporting on the findings derived from the Lymphopath network in France, AITL...
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References and Further Reading

  1. Attygalle, A., Cabeçadas, J., Gaulard, P., et al. (2014). Peripheral T- and NK-cell lymphomas and their mimics: Taking a step forward – Report on the lymphoma workshop of the XVI meeting of the European Association for Haematopathology in Lisbon 2012. Histopathology, 64(2), 171–199.CrossRefPubMedCentralGoogle Scholar
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  5. Dobay, M. P., Lemonnier, F., Missiaglia, E., Bastard, C., Vallois, D., Jais, J. P., et al. (2017). Integrative clinicopathological and molecular analyses of angioimmunoblastic T-cell lymphoma and other nodal lymphomas of follicular helper T-cell origin. Haematologica, 102(4), e148–ee51.CrossRefPubMedCentralGoogle Scholar
  6. Federico, M., Rudiger, T., Bellei, M., et al. (2013). Clinicopathologic characteristics of angioimmunoblastic T-cell lymphoma: Analysis of the international peripheral T-cell lymphoma project. Journal of Clinical Oncology, 31(2), 240–246.CrossRefPubMedCentralGoogle Scholar
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  22. Tokunaga, T., Shimada, K., Yamamoto, K., et al. (2012). Retrospective analysis of prognostic factors for angioimmunoblastic T-cell lymphoma: A multicenter cooperative study in Japan. Blood, 119(12), 2837–2843.CrossRefPubMedCentralGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Institute of PathologyUniversity Hospital Lausanne CHUVLausanneSwitzerland