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Verrucous Carcinoma, Larynx

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  • First Online:
Head and Neck Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 186 Accesses

Synonyms

Ackerman’s tumor

Definition

Verrucous carcinoma of the larynx is a rare variant of well-differentiated squamous cell carcinoma (SCC) with a favorable prognosis. It has an exophytic, warty macroscopic appearance and is histologically a well-differentiated tumor lacking cytological signs of malignancy. It grows slowly, and even though it is locally invasive and can cause extensive destruction if left untreated, pure verrucous carcinoma is believed to be unable to metastasize. Hybrid carcinomas also exist, composed of verrucous carcinoma and foci of conventional SCC, and harbor a metastatic potential (Cardesa and Zidar 2005).

Etiopathogenesis of laryngeal verrucous carcinoma is unclear, similarly to verrucous carcinoma at other sites. Most patients are reported to be current or former cigarette smokers. Controversial data exists on the pathogenetic role of human papillomaviruses (HPV), with reported incidence of HPV detection in verrucous carcinoma spanning from 0 % to 85 %.

Verru...

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References and Further Reading

  • Anderson, M., Muro-Cacho, C., Cordero, J., Livingston, S., & Muñoz-Antonia, T. (1999). Transforming growth factor β receptor in verrucous and squamous cell carcinoma. Archives of Otolaryngology – Head & Neck Surgery, 125, 849–854.

    Article  CAS  Google Scholar 

  • Cardesa, A., & Zidar, N. (2005). Verrucous carcinoma. In L. Barnes, J. W. Eveson, P. Reichart, & D. Sidransky (Eds.), World Health Organization classification of tumours. Pathology and genetics of the head and neck tumours (pp. 122–123). Lyon: IARC Press.

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  • Odar, K., Zidar, N., Bonin, S., Gale, N., Cardesa, A., & Stanta, G. (2012a). Desmosomes in verrucous carcinoma of the head and neck. Histology and Histopathology, 27, 467–474.

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  • Odar, K., Boštjančič, E., Gale, N., Glavač, D., & Zidar, N. (2012b). Differential expression of microRNAs miR-21, miR-31, miR-203, miR-125a–5p and miR-125b and proteins PTEN and p63 in verrucous carcinoma of the head and neck. Histopathology, 61, 257–265.

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  • Orvidas, L. J., Kerry, D. K., Lewis, J. E., & Suman, V. J. (1998). Verrucous carcinoma of the larynx. Head & Neck, 20, 197–203.

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  • Strojan, P., Šmid, L., Čižmarevič, B., Žagar, T., & Auersperg, M. (2006). Verrucous carcinoma of the larynx: Determining the best treatment option. European Journal of Surgical Oncology, 32, 984–988.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Institute of Pathology, Faculty of Medicine, University of Ljubljana, Korytkova 2, Ljubljana, 1000, Slovenia

    Nina Zidar & Katarina Odar

Authors
  1. Nina Zidar
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  2. Katarina Odar
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Corresponding author

Correspondence to Nina Zidar .

Editor information

Editors and Affiliations

  1. Faculty of Medicine, Institute of Pathology, University of Ljubljana, Ljubljana, Slovenia

    Metka Volavšek

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© 2016 Springer International Publishing Switzerland

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Zidar, N., Odar, K. (2016). Verrucous Carcinoma, Larynx. In: Volavšek, M. (eds) Head and Neck Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28618-1_1873

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  • DOI: https://doi.org/10.1007/978-3-319-28618-1_1873

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28617-4

  • Online ISBN: 978-3-319-28618-1

  • eBook Packages: MedicineReference Module Medicine

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