Hepatic Mesotheliomas and Related Neoplasms

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Abstract

Mesotheliomas form a complex group of neoplasms with a biologic behavior that ranges from benign to malignant. Apart from pleural mesothelioma, which has a strong association with asbestos exposure, these neoplasms also develop in other serosal surfaces, including the liver capsule, and in some inner organs, e.g., the heart and liver. Benign cystic mesothelioma, a neoplasm mainly occurring in middle-aged women with a previous history of gynecological surgery, rarely develops in the liver. Few cases of malignant epithelial monophasic mesothelioma of the liver have been reported. Also mesothelioma with a biphasic pattern was observed in the liver, in part associated with asbestos exposure. A second type of mesothelial neoplasm is adenomatoid tumor. This tumor typically occurs in the genital tract, but several extragenital sites have been found, including the heart, the mediastinum and the gastrointestinal tract. Few observations document primary adenomatoid tumor of the liver.

Keywords

Malignant Pleural Mesothelioma Malignant Mesothelioma Asbestos Exposure Peritoneal Mesothelioma Adenomatoid Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Adachi S, Yanagawa T, Furumoto A, Fujino S, Doi R, Dono K, Kitada M (2012) Adenomatoid tumor of the liver. Pathol Int 62:153–154CrossRefPubMedGoogle Scholar
  2. Addis B, Roche H (2009) Problems in mesothelioma diagnosis. Histopathology 54:55–68CrossRefPubMedGoogle Scholar
  3. Akhtar M, Reyes F, Young I (1976) Elastogenesis in adenomatoid tumor: histochemical and ultrastructural observations. Cancer 37:338–345CrossRefPubMedGoogle Scholar
  4. Anthony PP (1973) Primary carcinoma of the liver: a study of 282 cases in Ugandan Africans. J Pathol 110:37–48CrossRefPubMedGoogle Scholar
  5. Antropoli M, Freda F, Apicella A, Nunziata L, Cutolo PP, Antropoli C, Petronella P (2002) Peritoneal multicystic mesothelioma: unusual case of localization in the left lobe of the liver (in Italian). Chir Ital 54:897–902PubMedGoogle Scholar
  6. Augustine AJ, Pai RK, Pai R, Diaz EA, Prabhu HS, Swaroop R (2001) Mesothelial cyst at porta hepatis. Indian J Gastroenterol 20:35–36PubMedGoogle Scholar
  7. Betta PG, Magnani C, Bensi T, Trincheri NF, Orecchia S (2012) Immunohistochemical and molecular diagnostics of pleural malignant mesothelioma. Arch Pathol Lab Med 136:253–261CrossRefPubMedGoogle Scholar
  8. Buchholz BM, Gütgemann I, Fischer HP, Gorschlüter M, Türler A, Kalff JC, Hirner A, Standop J (2009) Lymph node dissection in primary intrahepatic malignant mesothelioma: case report and implication for diagnosis and therapy. Langenbecks Arch Surg 394:1123–1130CrossRefPubMedGoogle Scholar
  10. Chua TC, Yan TD, Morris DL (2009) Surgical biology for the clinician: peritoneal mesothelioma :current understanding and management. Can J Surg 52:59–64PubMedPubMedCentralGoogle Scholar
  11. Cimbaluk D, Kasuganti D, Kluskens L, Reddy V, Gattuso P (2006) Malignant biphasic pleural mesothelioma metastatic to the liver diagnosed by fine-needle aspiration. Diagn Cytopathol 34:33–36CrossRefPubMedGoogle Scholar
  12. Corson JM (2004) Pathology of mesothelioma. Thorac Surg Clin 14:447–460CrossRefPubMedGoogle Scholar
  13. Cusatelli P, Altavilla G, Merchetti M (1997) Benign cystic mesothelioma of the peritoneum: a case report. Eur J Gynaecol 18:124–126Google Scholar
  14. Datta RU, Paty PB (1997) Cystic mesothelioma of the peritoneum. Eur J Surg Oncol 23:461–462CrossRefPubMedGoogle Scholar
  15. Davidson B (2008) New diagnostic and molecular characteristics of malignant mesothelioma. Ultrastruct Pathol 32:227–240CrossRefPubMedGoogle Scholar
  16. Delahunt B, Eble JN, King D, Bethwaite PB, Nacey JN, Thornton A (2000) Immunohistochemical evidence for mesothelial origin of paratesticular adenomatoid tumour. Histopathology 36:109–115CrossRefPubMedGoogle Scholar
  17. DeStephano DB, Wesley JR, Heidelberger KP, Hutchinson RJ, Blane CE, Coran AG (1985) Primitive cystic hepatic neoplasm of infancy with mesothelial differentiation: report of a case. Pediatr Pathol 4:291–302CrossRefPubMedGoogle Scholar
  18. Di Blasi A, Boscaino A, De Dominicis G, Marino Marsilia G, D’Antonio A, Nappi O (2004) Multicystic mesothelioma of the liver with secondary involvement of peritoneum and inguinal region. Int J Surg Pathol 12:87–91CrossRefPubMedGoogle Scholar
  19. Doval DC, Pande SB, Sharma JB, Rao SA, Prakash N, Vaid AK (2007) Report of a case of pericardial mesothelioma with liver metastases responding well to pemetrexed and platinum-based chemotherapy. J Thorac Oncol 2:780–781CrossRefPubMedGoogle Scholar
  20. Edmondson HA, Steiner PE (1954) Primary carcinoma of the liver: a study of 100 cases among 48900 necropsies. Cancer 7:462–503CrossRefPubMedGoogle Scholar
  22. Flemming P, Becker T, Klempnauer J, Hogemann D, Kreft A, Kreipe HH (2002) Benign cystic mesothelioma of the liver. Am J Surg Pathol 26:1523–1527CrossRefPubMedGoogle Scholar
  24. Glatz K, Wegmann W (2000) Papillary adenomatoid tumour of the adrenal gland. Histopathology 37:376–377CrossRefPubMedGoogle Scholar
  25. Golden A, Ash J (1945) Adenomatoid tumour of the genital tract. Am J Pathol 21:63–79PubMedPubMedCentralGoogle Scholar
  26. Gong Y, Ren R, Ordonez NG, Sun X, Sneige N (2005) Fine needle aspiration cytology of well-differentiated papillary mesothelioma: a case report. Acta Cytol 49:537–542CrossRefPubMedGoogle Scholar
  27. Gonzalez-Moreno S, Yan H, Alcorn KW, Sugarbaker PH (2002) Malignant transformation of “benign” cystic mesothelioma of the peritoneum. J Surg Oncol 79:243–251CrossRefPubMedGoogle Scholar
  28. Greillier L, Baas P, Welch JJ, Hasan B, Passioukov A (2008) Biomarkers for malignant pleural mesothelioma: current status. Mol Diagn Ther 12:375–390CrossRefPubMedGoogle Scholar
  29. Grosse-Holz M, Streitberg V, Thies J, Lenhart M, Seitz G (2013) Cystic tumor on the porta hepatis (in German). Pathologe 34:463–465CrossRefPubMedGoogle Scholar
  30. Gütgemann I, Standop J, Fischer HP (2006) Primary intrahepatic malignant mesothelioma of epithelioid type. Virchows Arch 448:655–658CrossRefPubMedGoogle Scholar
  31. Häfner M, Novacek G, Herbst F, Ullrich R, Gangl A (2002) Giant benign cystic mesothelioma: a case report and review of literature. Eur J Gastroenterol Hepatol 14:77–80CrossRefPubMedGoogle Scholar
  33. Hanrahan JB (1963) A combined papillary mesothelioma and adenomatoid tumor of the omentum; report of a case. Cancer 16:1497–1500CrossRefPubMedGoogle Scholar
  34. Hayes SJ, Clark P, Mathias R, Formela L, Vickers J, Armstrong GR (2007) Multiple adenomatoid tumours in the liver and peritoneum. J Clin Pathol 60:722–725CrossRefPubMedPubMedCentralGoogle Scholar
  35. Hes O, Perez-Montiel DM, Alvarado Cabrero I, Zamecnik M, Podhola M, Sulc M, Hora M, Mukensnabl P et al (2003) Thread-like bridging strands: a morphologic feature present in all adenomatoid tumors. Ann Diagn Pathol 7:273–277CrossRefPubMedGoogle Scholar
  36. Hoffman CJ, Hales ED, Malachowski ME, Pietrafitta JJ (1989) Mesothelial cyst of the gallbladder. J Clin Ultrasound 17:50–52CrossRefPubMedGoogle Scholar
  37. Hollevoet K, Nackaerts K, Gosselin R, De Wever W, Bosquée L, De Vuyst P, Germonpré P et al (2011) Soluble mesothelin, megakaryocyte potentiating factor, and osteopontin as markers of patient response and outcome in mesothelioma. J Thorac Oncol 6:1930–1937CrossRefPubMedGoogle Scholar
  39. Ikeda K, Tate G, Suzuki T, Kitamura T, Mitsuya T (2010) IMP3/L523S, a novel immunocytochemical marker that distinguishes benign and malignant cells: the expression profiles of IMP3/L523S in effusion cytology. Hum Pathol 41:745–750CrossRefPubMedGoogle Scholar
  40. Imura J, Ichikawa K, Takeda J, Iwasaki Y, Tomita S, Kubota K, Fujimori T (2002) Localized malignant mesothelioma of the epithelial type occurring as a primary hepatic neoplasm: a case report with review of the literature. APMIS 110:789–794CrossRefPubMedGoogle Scholar
  42. Iwanaka T, Nakanishi H, Tsuchida Y, Oka T, Honna T, Shimizu K (1995) Familial multiple mesothelial cysts of the spleen. J Pediatr Surg 30:1743–1745CrossRefPubMedGoogle Scholar
  46. Kim JB, Yu E, Shim JH, Song GW, Kim GU, Jin YJ, Park HS (2012) Concurrent hepatic adenomatoid tumor and hepatic hemangioma: a case report. Clin Mol Hepatol 18:229–234CrossRefPubMedPubMedCentralGoogle Scholar
  47. Klebe S, Brownlee NA, Mahar A, Burchette JL, Sporn TA, Vollmer RT, Roggli VL (2010) Sarcomatoid mesothelioma: a clinical-pathologic correlation of 326 cases. Mod Pathol 23:470–479CrossRefPubMedGoogle Scholar
  49. Kuroda N, Toi M, Hiroi M, Lee GH (2007) Diagnostic pitfall of D2-40 in adenomatoid tumour. Histopathology 51:719–721CrossRefPubMedGoogle Scholar
  50. Leonardou P, Semelka RC, Kanematsu M, Braga L, Woosley JT (2003) Primary malignant mesothelioma of the liver: MR imaging findings. Magn Reson Imaging 21:1091–1093CrossRefPubMedGoogle Scholar
  51. Luoma R, Raboei E (2003) Supradiaphragmatic accessory liver: a rare cause of respiratory distress in a neonate. J Pediatr Surg 38:1413–1414CrossRefPubMedGoogle Scholar
  52. Marchevsky AM (2008) Application of immunohistochemistry to the diagnosis of malignant mesothelioma. Arch Pathol Lab Med 132:397–401PubMedGoogle Scholar
  53. Marubayashi S, Ohdan H, Asahara T, Ikeda M, Hinoi T, Fukuma K, Maeda T, Oshiro Y, Shimamoto F, Dohi K (1998) Malignant mesothelioma originating in the hepatic falciform ligament: report of a case. Surg Today 28:929–931CrossRefPubMedGoogle Scholar
  54. Matsukuma S, Aida S, Hata Y, Sugiura Y, Tamai S (1996) Localized malignant peritoneal mesothelioma containing rhabdoid cells. Pathol Int 46:389–391CrossRefPubMedGoogle Scholar
  55. McCullagh M, Keen C, Dykes E (1994) Cystic mesothelioma of the peritoneum: a rare cause of ‘ascites’ in children. J Pediatr Surg 29:1205–1207CrossRefPubMedGoogle Scholar
  56. Mennemeyer R, Smith M (1979) Multicystic peritoneal mesothelioma: a case report with electron microscopy of a case mimicking intra-abdominal cystic hygroma (lymphangioma). Cancer 44:692–698CrossRefPubMedGoogle Scholar
  58. Mott FE (2012) Mesothelioma: a review. Ochsner J 12:70–79PubMedPubMedCentralGoogle Scholar
  59. Nagata S, Aishima S, Fukuzawa K, Takagi H, Yonematsu H, Iwashita Y, Kinoshita T, Wakasugi K (2008) Adenomatoid tumour of the liver. J Clin Pathol 61:777–780CrossRefPubMedPubMedCentralGoogle Scholar
  60. Nagata S, Tomoeda M, Kubo C, Yoshizawa H, Yuki M, Kitamura M, Takenaka A, Nakanishi K et al (2011) Malignant mesothelioma of the peritoneum invading the liver and mimicking metastatic carcinoma: a case report. Pathol Res Pract 207:395–398CrossRefPubMedGoogle Scholar
  61. Nakashima T, Okuda K, Kojiro M et al (1983) Pathology of hepatocellular carcinoma in Japan. 232 consecutive cases autopsied in ten years. Cancer 51:863–877CrossRefPubMedGoogle Scholar
  63. Ohta Y, Shridhar V, Bright RK, Kalemkerian GP, Du W, Carbone M et al (1999) VEGF and VEGF type C play an important role in angiogenesis and lymphangiogenesis in human malignant mesothelioma tumours. Br J Cancer 81:54–61CrossRefPubMedPubMedCentralGoogle Scholar
  64. Ordonez NG (1999) The immunohistochemical diagnosis of epithelial mesothelioma. Hum Pathol 30:313–323CrossRefPubMedGoogle Scholar
  65. Otsuki Y, Shimizu S, Hosoda Y, Nagasawa M, Sato Y, Kobayashi H (2005) Hepatocellular carcinoma with mesothelioma-like dissemination. Pathol Int 55:738–744CrossRefPubMedGoogle Scholar
  67. Patton RB, Horn RC (1964) Primary liver carcinoma. Autopsy study of 60 cases. Cancer 17:757–768CrossRefPubMedGoogle Scholar
  68. Phillips V, McCluggage WG, Young RH (2007) Oxyphilic adenomatoid tumor of the ovary: a case report with discussion of the differential diagnosis of ovarian tumors with vacuoles and related spaces. Int J Gynecol Pathol 26:16–20CrossRefPubMedGoogle Scholar
  69. Pinheiro C, Longatto-Filho A, Soares TR, Pereira H, Bedrossian C, Michael C, Schmitt FC et al (2012) CD147 immunohistochemistry discriminates between reactive mesothelial cells and malignant mesothelioma. Diagn Cytopathol 40:478–483CrossRefPubMedGoogle Scholar
  71. Ross MJ, Welch WR, Scully RE (1989) Multilocular peritoneal inclusion cysts (so-called cystic mesotheliomas). Cancer 64:1336–1346CrossRefPubMedGoogle Scholar
  72. Rougemont AL, Sartelet H, Oligny LL, Bensoussan A, Yazbeck S, Fournet JC (2007) Accessory liver lobe with mesothelial inclusion cysts in an omphalocele: a new malformative association. Pediatr Dev Pathol 10:224–228CrossRefPubMedGoogle Scholar
  73. Rout P, Rameshkumar K, Srikrishna NV (1999) Hepatic mesothelioma. Indian J Gastroenterol 18:176–177PubMedGoogle Scholar
  74. Samedi V, White S, Zimarowski MJ, Harris A, Saffitz J, Wang HH (2010) Metastatic peritoneal mesothelioma in the setting of recurrent ascites: a case report. Diagn Cytopathol 38:675–681CrossRefPubMedGoogle Scholar
  76. Satoh Y, Hiraguchi M, Matuura T, Takasu K (1998) Immunohistochemical evidence of the mesothelial histogenesis of a uterine adenomatoid tumor. J Obstet Gynaecol Res 24:91–101CrossRefPubMedGoogle Scholar
  77. Sawh RN, Malpica A, Deavers MT, Liu J, Silva EG (2003) Benign cystic mesothelioma of the peritoneum: a clinicopathologic study of 17 cases and immunohistochemical analysis of estrogen and progesterone receptor status. Hum Pathol 34:369–374CrossRefPubMedGoogle Scholar
  78. Schwartz EJ, Longacre TA (2004) Adenomatoid tumors of the female and male genital tracts express WT1. Int J Gynecol Pathol 23:123–128CrossRefPubMedGoogle Scholar
  79. Shing HP, Wu TT, Hwang B, Chin TW, Wei CF, Tasy SH (1997) Malignant epithelial neoplasm consistent with primitive cystic hepatic neoplasm with mesothelial differentiation: a case report. Zhonghua Yi Xue Za Zhi (Taipei) 59:265–268Google Scholar
  80. Sichletidis L, Chloros D, Spyratos D, Haidich AB, Fourkiotou I, Kakoura M, Patakas D (2008) Mortality from occupational exposure to relatively pure chrysotile: a 39-year study. Respiration 78:63–68CrossRefPubMedGoogle Scholar
  81. Silva AR, Fragoso AC, Oliveira M, Costa-Maia J, Estevao-Costa A, Bessa-Monteiro A, Campos M (2009) Laparoscopic excision of a hepatic mesothelial cyst (in Spanish). Cir Pediatr 22:229–232PubMedGoogle Scholar
  82. Skinnider BF, Young RH (2004) Infarcted adenomatoid tumor: a report of five cases of a facet of a benign neoplasm that may cause diagnostic difficulty. Am J Surg Pathol 28:77–83CrossRefPubMedGoogle Scholar
  83. Szendröi M, Németh L, Vajta G (1983) Asbestos bodies in a bile duct cancer after occupational exposure. Environ Res 30:270–280CrossRefPubMedGoogle Scholar
  84. Takeuchi N, Nakai M, Sato M (2008) A case of omental mesothelioma presenting with laminar thickening of omentum-appearance of diffuse malignant peritoneal mesothelioma (in Japanese). Gan To Kagaku Ryoho 35:677–681PubMedGoogle Scholar
  85. Timonera ER, Paiva ME, Lopes JM, Eloy C, van der Kwast T, Asa SL (2008) Composite adenomatoid tumor and myelolipoma of adrenal gland: report of 2 cases. Arch Pathol Lab Med 132:265–267PubMedGoogle Scholar
  86. Tischoff I, Neid M, Neumann V, Tannapfel A (2011) Pathohistological diagnosis and differential diagnosis. Recent Results Cancer Res 189:57–78CrossRefPubMedGoogle Scholar
  87. Umezu H, Kuwata K, Ebe Y, Yamamoto T, Naito M, Yamato Y, Ishiyama T, Tsuchida M, Okuizumi M, Ishikawa H, Koizumi N (2002) Microcystic variant of localized malignant mesothelioma accompanying an adenomatoid tumor-like lesion. Pathol Int 52:416–422CrossRefPubMedGoogle Scholar
  88. van der Bij S, Schaake E, Koffijberg H, Burgers JA, de Mol BA, Moons KG (2011) Markers for the non-invasive diagnosis of mesothelioma: a systematic review. Br J Cancer 104:1325–1333CrossRefPubMedPubMedCentralGoogle Scholar
  92. Yuki K, Hirohashi S, Sakamoto M, Kanai T, Shimosato Y (1990) Growth and spread of hepatocellular carcinoma. A review of 240 consecutive autopsy cases. Cancer 66:2174–2179CrossRefPubMedGoogle Scholar
  93. Zamecnik M, Gomolcak P (2000) Composite multicystic mesothelioma and adenomatoid tumor of the ovary: additional observation suggesting common histogenesis of both lesions. Cesk Patol 36:160–162PubMedGoogle Scholar

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© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.University of BernBernSwitzerland

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