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Extrahepatic Cholangiocarcinoma: Carcinoma of the Middle and Distal Common Bile Duct (Middle and Lower Bile Duct Carcinomas)

ICD-O code biliary-type adenocarcinoma 8140/3
  • Arthur ZimmermannEmail author
Reference work entry

Abstract

Cholangiocarcinomas of the distal bile duct system are conventionally defined as neoplasms located between the cystic duct entry and the end of the common bile duct in the ampullary region (infrahilar cancers). Cancers arising in a segment just distal to the cystic duct entry are sometimes classified as tumors of the duct mid-region, due to their rather distinct growth pattern (middle duct cancer), but middle and distal cancers are put together into one category by other authors. Japanese authors identified two infrahilar tumor groups and denote middle carcinomas by the abbreviation Bm and distal carcinomas by Bi. Distal-most forms of cholangiocarcinoma may be difficult to distinguish from periampullary carcinomas. Infrahilar variants of extrahepatic cholangiocarcinoma account for 20–30 % of all bile duct carcinomas, but incidence rates vary considerably among different regions of the world, due to varying prevalence of etiologic factors such as stone disease and liver fluke infestation. Macroscopically, infrahilar cholangiocarcinomas display nodular stenosing masses, masses with a tubular configuration, ulcerated tumors, diffusely growing tumors, and exophytic growths, the latter predominating in distal-most lesions.

Keywords

Bile Duct Common Bile Duct Perineural Invasion Extrahepatic Bile Duct Signet Ring Cell Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Agrawal V, Garg PK, Mohanty D, Jaswal V (2012) Umbilical nodule in cholangiocarcinoma. Sister Mary Joseph Nodule. Saudi J Gastroenterol 18:345–346PubMedPubMedCentralCrossRefGoogle Scholar
  2. Akayadin M, Ersoy YE, Erozgen F, Ferlengez E, Kaplan R, Celik A, Memmi N (2009) Tubulovillous adenoma in the common bile duct causing obstructive jaundice. Acta Gastroenterol Belg 72:450–454Google Scholar
  3. Albores-Saavedra J, Delgado R, Henson DE (1999) Well-differentiated adenocarcinoma, gastric foveolar type, of the extrahepatic bile ducts: a previously unrecognized and distinctive morphologic variant of bile duct carcinoma. Ann Diagn Pathol 3:75–80PubMedCrossRefGoogle Scholar
  4. Albores-Saavedra J, Henson DE, Klimstra DS (eds) (2000a) Tumors of the gallbladder, extrahepatic bile ducts, and ampulla of Vater. Armed Forces Institute of Pathology, Washington, DCGoogle Scholar
  5. Albores-Saavedra J, Murakata L, Krueger JE, Henson DE (2000b) Noninvasive and minimally invasive papillary carcinomas of the extrahepatic bile ducts. Cancer 89:508–515PubMedCrossRefGoogle Scholar
  6. Albores-Saavedra J, Adsay NV, Crawford JM, Klimstra DS (2010) Carcinoma of the gallbladder and extrahepatic bile ducts. In: Bosman FT (ed) WHO classification of tumours of the digestive system. IARC, Lyon, pp 266–273Google Scholar
  7. Albores-Saavedra J, Chablé-Montero F, Méndez-Sanchez N, Mercado MA, Vilatoba-Chapa M et al (2012) Adenocarcinoma with pyloric gland phenotype of the extrahepatic bile ducts: a previously unrecognized and distinctive morphologic variant of extrahepatic bile duct carcinoma. Hum Pathol 43:2292–2298PubMedCrossRefGoogle Scholar
  8. Albu S, Tantau M, Sparchez Z, Branda H, Suteu T, Badea R, Pascu O (2005) Diagnosis and treatment of extrahepatic cholangiocarcinoma: results in a series of 124 patients. Rom J Gastroenterol 14:33–36PubMedGoogle Scholar
  9. Alden ME, Waterman FM, Topham AK, Barbot DJ, Shapiro MJ, Mohiuddin M (1995) Cholangiocarcinoma: clinical significance of tumor location along the extrahepatic bile duct. Radiology 197:511–516PubMedCrossRefGoogle Scholar
  10. Alexander F, Rossi RL, O’Bryan M, Khettry U, Braasch JW, Watkins E (1984) Biliary carcinoma. A review of 109 cases. Am J Surg 147:503–509PubMedCrossRefGoogle Scholar
  11. Allen PJ, Reiner AS, Gonen M, Klimstra DK, Blumgart LH, Brennan MF, D’Angelica M et al (2008) Extrahepatic cholangiocarcinoma: a comparison of patients with resected proximal and distal lesions. HPB (Oxford) 10:341–346CrossRefGoogle Scholar
  12. Alper E, Üstün Dao Y, Akca S, Arabul M, Buyrac Z, Baydar B (2011) The utility of radial endosonographic features in the diagnosis of cholangiocarcinoma arising from the distal common bile duct. Minerva Gastroenterol Dietol 57:434–435PubMedGoogle Scholar
  13. Al-Salamah SM, Khan IA, Khalid K, Al-Shakweer WA (2005) Castleman disease presenting as obstructive jaundice. Saudi Med J 26:111–113PubMedGoogle Scholar
  14. Anderson JB, Cooper MJ, Williamson RC (1985) Adenocarcinoma of the extrahepatic biliary tree. Ann R Coll Surg Engl 67:139–143PubMedPubMedCentralGoogle Scholar
  15. Aoki H, Kanazawa T, Fujiwara Y, Morihiro T, Takehara K, Seita M, Ohara T, Arata T, Nakagawa H, Tanakaya K et al (2012) A case of adenosquamous carcinoma of lower extrahepatic bile duct (in Japanese). Gan To Kagaku Ryoho 39:131–133PubMedGoogle Scholar
  16. Arakura N, Hasebe O, Yokosawa S, Imai Y, Furuta S, Hosaka N (2003) A case of small cell carcinoma of the extrahepatic bile duct which could be diagnosed before operation (in Japanese). Nihon Shokakibyo Gakkai Zasshi 100:190–194PubMedGoogle Scholar
  17. Bahra M, Langrehr JM, Neuhaus P (2006) Carcinoma of the distal bile duct (in German). Chirurg 77:335–340PubMedCrossRefGoogle Scholar
  18. Bahra M, Jacob D, Langrehr JM, Neumann UP, Neuhaus P (2008) Carcinoma of the distal and middle bile duct: surgical results, prognostic factors, and long-term follow-up. J Hepatobiliary Pancreat Surg 15:501–507PubMedCrossRefGoogle Scholar
  19. Bass G, O’Mahony CA, Smith R, Dennison MS, Goss JA (2010) Biliary epithelial metastasis of squamous carcinoma of the anus. Ir J Med Sci 179:605–606PubMedCrossRefGoogle Scholar
  20. Bhuiya MR, Nimura Y, Kamiya J, Kondo S, Fukata S, Hayakawa N, Shionoya S (1992) Clinicopathologic studies on perineural invasion of bile duct carcinoma. Ann Surg 215:344–349PubMedPubMedCentralCrossRefGoogle Scholar
  21. Biswas A, Husain EA, Feakins RM, Abraham AT (2007) Heterotopic pancreas mimicking cholangiocarcinoma. Case report and literature review. JOP 8:28–34PubMedGoogle Scholar
  22. Bortolasi L, Burgart LJ, Tsiotos CC, Luque-De Leon E, Sarr MG (2000) Adenocarcinoma of the distal bile duct. A clinicopathologic outcome analysis after curative resection. Dig Surg 17:36–41PubMedCrossRefGoogle Scholar
  23. Broomé U, Löfberg R, Veress B, Eriksson LS (1995) Primary sclerosing cholangitis and ulcerating colitis: evidence for increased neoplastic potential. Hepatology 22:1404–1408PubMedGoogle Scholar
  24. Brown DB, Strang R, Gordon J, Hendry EB (1961) Primary carcinoma of the extrahepatic bile-ducts. Br J Surg 49:22–28PubMedCrossRefGoogle Scholar
  25. Burger RE, Meeker WR, Luckett PM (1978) Squamous cell carcinoma of the common bile duct. South Med J 71:216–219PubMedCrossRefGoogle Scholar
  26. Cha IH, Kim JN, Kim YS, Ryu SH, Moon JS, Lee HK (2013) Metastatic common bile duct cancer from pulmonary adenocarcinoma presenting as obstructive jaundice. Korean J Gastroenterol 61:50–53PubMedCrossRefGoogle Scholar
  27. Chao TC, Greager JA (1991) Carcinoma of the extrahepatic bile ducts. J Surg Oncol 46:145–150PubMedCrossRefGoogle Scholar
  28. Chen MF, Jan YY, Chen TC (1998) Clinical studies of mucin-producing cholangiocellular carcinoma: a study of 22 histopathology-proven cases. Ann Surg 227:63–69PubMedPubMedCentralCrossRefGoogle Scholar
  29. Chen CH, Yang CC, Yeh YH, Yang JC, Chou DA (1999) Pancreatic tuberculosis with obstructive jaundice – a case report. Am J Gastroenterol 94:2534–2536PubMedGoogle Scholar
  30. Cheney WF (1914) Diagnosis of cancer of the common duct. Arch Diagn 7:335–338Google Scholar
  31. Cheng Q, Luo X, Zhang B, Jiang X, Yi B, Wu M (2007) Distal bile duct carcinoma: prognostic factors after curative surgery. A series of 112 cases. Ann Surg Oncol 14:1212–1219PubMedCrossRefGoogle Scholar
  32. Cho SB, Park SY, Joo YE (2009) Small cell carcinoma of extrahepatic bile duct presenting with hemobilia (in Korean). Korean J Gastroenterol 54:186–190PubMedCrossRefGoogle Scholar
  33. Colovic R, Grubor N, Jesic R, Micev M, Jovanovic T, Colovic N, Atkinson HD (2008) Tuberculous lymphadenitis as a cause of obstructive jaundice: a case report and literature review. World J Gastroenterol 14:3098–3100PubMedPubMedCentralCrossRefGoogle Scholar
  34. Dancygier H, Rösch T, Lorenz R, Gössner W, Siewert JR, Classen M (1988) Preoperative staging of a distal common bile duct tumor by endoscopic ultrasound. Gastroenterology 95:219–222PubMedCrossRefGoogle Scholar
  35. Davis RI, Sloan JM, Hood JM, Maxwell P (1988) Carcinoma of the extrahepatic biliary tract: a clinicopathological and immunohistochemical study. Histopathology 12:623–631PubMedCrossRefGoogle Scholar
  36. DeOliveira ML, Cunningham SC, Cameron JL, Kamanagar F, Winter JM, Lillemoe KD et al (2007) Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution. Ann Surg 245:755–762PubMedPubMedCentralCrossRefGoogle Scholar
  37. Devic G, Gallavardin L (1901) Etude sur le cancer primitif des canaux biliaires, cholédoque, hépatique et cystique. Rev Méd 21:557–575Google Scholar
  38. Dick JC (1939) Carcinoma of the lower end of the bile duct. Br J Surg 26:756CrossRefGoogle Scholar
  39. Dickson PV, Behrman SW (2014) Distal cholangiocarcinoma. Surg Clin N Am 94:325–342PubMedCrossRefGoogle Scholar
  40. Dote H, Ohta K, Nishimura R, Teramoto N, Asagi A, Nadano S, Hamada M, Yoshida I, Kobatake T, Nozaki I et al (2009) Primary extranodal non-Hodgkin’s lymphoma of the common bile duct manifesting as obstructive jaundice: report of a case. Surg Today 39:448–451PubMedCrossRefGoogle Scholar
  41. Dowaki S, Kijima H, Kashiwagi H, Tobita K, Ohtani Y, Sugio Y, Sekka T, Osamura RY et al (2003) Undifferentiated spindle and giant cell carcinoma of the common bile duct. Tokai J Exp Clin Med 28:127–130PubMedGoogle Scholar
  42. Durand-Fardel M (1840) Recherches anat-path, sur la vésicule et les canaux biliaires. Arch gen de Med 8:167–171Google Scholar
  43. Evander A, Fredlund P, Hoevels J, Ihse I, Bengmark S (1980) Evaluation of aggressive surgery for carcinoma of the extrahepatic bile ducts. Ann Surg 191:23–29PubMedPubMedCentralCrossRefGoogle Scholar
  44. Ewing J (1919) Neoplastic diseases. Saunders, Philadelphia, p 1027Google Scholar
  45. Ewing J (1928) Neoplastic diseases, 3rd edn. Saunders, Philadelphia, pp 698–701Google Scholar
  46. Fatima S, Ahmad Z, Qureshi A, Minhas K, Pal I (2008) Minimally invasive papillary carcinoma of the extrahepatic bile ducts. J Coll Phys Surg Pak 18:649–651Google Scholar
  47. Fleming KA, Boberg KM, Glaumann H, Bergquist A, Smith D, Clausen OP (2001) Biliary dysplasia as a marker of cholangiocarcinoma in primary sclerosing cholangitis. J Hepatol 34:360–365PubMedCrossRefGoogle Scholar
  48. Fletcher ND, Wise PE, Sharp KW (2004) Common bile duct papillary adenoma causing obstructive jaundice: case report and review of the literature. Am Surg 70:448–452PubMedGoogle Scholar
  49. Fujikawa T, Tanaka A, Abe T, Yoshimoto H, Tokumitsu Y, Tada S, Matsumoto Y, Maekawa Y et al (2011) Undifferentiated carcinoma of the common bile duct with intraductal tumor thrombi: report of a case. Surg Today 41:579–584PubMedCrossRefGoogle Scholar
  50. Goo JC, Yi MY, Jeon WJ, Seo JC, Chae HB, Park SM, Youn SJ, Kim SH, Choi JW (2006) A case of leiomyoma in the common bile duct (in Korean). Korean J Gastroenterol 47:77–81PubMedGoogle Scholar
  51. Gozzetti G, Principe A (1995) Primary carcinoma of the middle and distal third of the common bile duct, diagnosis, treatment and results (in Italian). Chir Ital 47:12–17PubMedGoogle Scholar
  52. Gulsrud PO, Feinberg M, Koretz RL (1979) Rapid development of cirrhosis secondary to squamous cell carcinoma of the common bile duct. Dig Dis Sci 24:166–169PubMedCrossRefGoogle Scholar
  53. Haworth AC, Manley PN, Groll A, Pace R (1989) Bile duct carcinoma and biliary tract dysplasia in chronic ulcerative colitis. Arch Pathol Lab Med 113:434–436PubMedGoogle Scholar
  54. Hayashi N, Yamaguchi Y, Ogawa M (1993) Concomitant adenosquamous carcinoma of the common bile duct and early adenocarcinoma of the gall-bladder. J Gastroenterol Hepatol 8:607–612PubMedCrossRefGoogle Scholar
  55. Henson DE, Albores-Saavedra J, Corle D (1992) Carcinoma of the extrahepatic bile ducts. Histologic types, stage of disease, and survival rates. Cancer 70:1498–1501PubMedCrossRefGoogle Scholar
  56. Heron DE, Stein DE, Eschelman DJ, Topham AK, Waterman FM, Rosato EL, Alden M et al (2003) Cholangiocarcinoma: the impact of tumor location and treatment strategy on outcome. Am J Clin Oncol 26:422–428PubMedGoogle Scholar
  57. Hiraki M, Yakushiji H, Hashiguchi K, Harada S, Okada K, Goto Y, Ikeda H, Mori D et al (2007) Signet ring cell carcinoma of the lower bile duct with rapid growth: report of a case. Hepatogastroenterology 54:1922–1924PubMedGoogle Scholar
  58. Hoang MP, Murakata LA, Katabi N, Henson DE, Albores-Saavedra J (2002) Invasive papillary carcinomas of the extrahepatic bile ducts: a clinicopathologic and immunohistochemical study of 13 cases. Mod Pathol 15:1251–1258PubMedCrossRefGoogle Scholar
  59. Hong SM, Cho H, Lee OJ, Ro JY (2005) The number of metastatic lymph nodes in extrahepatic bile duct carcinoma as a prognostic factor. Am J Surg Pathol 29:1177–1183PubMedCrossRefGoogle Scholar
  60. Hong SM, Cho H, Moskaluk CA, Yu E, Zaika AI (2007) p63 and p73 expression in extrahepatic bile duct carcinoma and their clinical significance. J Mol Histol 38:167–175PubMedCrossRefGoogle Scholar
  61. Hong SM, Pawlik TM, Cho H, Aggarwal B, Goggins M, Hruban RH, Anders RA (2009) Depth of tumor invasion better predicts prognosis than the current American Joint Committee on cancer T classification for distal bile duct carcinoma. Surgery 146:250–257PubMedPubMedCentralCrossRefGoogle Scholar
  62. Hosonuma K, Sato K, Honma M, Kashiwabara K, Takahashi H, Takagi H, Mori M (2008) Small-cell carcinoma of the extrahepatic bile duct: a case report and review of the literature. Hepatol Int 2:129–132PubMedCrossRefGoogle Scholar
  63. Hughes JH, Niemann TH (1996) Adenosquamous carcinoma of the bile duct: cytologic features of brush specimens from two cases. Diagn Cytopathol 15:322–324PubMedCrossRefGoogle Scholar
  64. Igami T, Nagino M, Oda K, Nishio H, Ebata T, Yokoyama Y, Shimoyama Y (2009) Clinicopathologic study of cholangiocarcinoma with superficial spread. Ann Surg 249:296–302PubMedCrossRefGoogle Scholar
  65. Ito K, Ito H, Allen PJ, Gonen M, Klimstra D, D’Angelica MI, Fong Y, DeMatteo RP et al (2010) Adequate lymph node assessment for extrahepatic bile duct adenocarcinoma. Ann Surg 251:675–681PubMedCrossRefGoogle Scholar
  66. Ito Y, Kenmochi T, Egawa T, Hayashi S, Nagashima A, Kitagawa Y (2012) Diagnosis of distal cholangiocarcinoma after the removal of choledocholithiasis. Gastroenterol Res Pract 2012:396869PubMedPubMedCentralGoogle Scholar
  67. Ito Y, Kenmochi T, Egawa T, Hayashi S, Nagashima A, Kitagawa Y (2013) Clinicopathological features of early distal cholangiocarcinoma. Hepatogastroenterology 60:673–677PubMedGoogle Scholar
  68. Iwahashi N, Hayakawa N, Yamamoto H, Maki A, Kawabata Y, Murayama A, Nimura Y et al (1998) Mucosal bile duct carcinoma with superficial spread. J Hepatobiliary Pancreat Surg 5:221–225PubMedCrossRefGoogle Scholar
  69. Iwaki K, Shibata K, Ohta M, Endo Y, Uchida H, Tominaga M, Okunaga R, Kai S, Kitano S (2008) Adenomyomatous hyperplasia of the common bile duct: report of a case. Surg Today 38:85–89PubMedCrossRefGoogle Scholar
  70. Jakobs R, Albert J, Schilling D, Nuesse T, Riemann JF (2003) Schwannoma of the common bile duct: a rare cause of obstructive jaundice. Endoscopy 35:695–697PubMedCrossRefGoogle Scholar
  71. Jarnagin WR, Shoup M (2004) Surgical management of cholangiocarcinoma. Semin Liver Dis 24:189–199PubMedCrossRefGoogle Scholar
  72. Jarnagin WR, Fong Y, DeMatteo RP, Gonen M, Burke EC, Bodniewicz BS, Youssef BA et al (2001) Staging, resectability, and outcome in 225 patients with hilar cholangiocarcinoma. Ann Surg 234:507–517PubMedPubMedCentralCrossRefGoogle Scholar
  73. Johnson SR, Kelly BS, Pennington LJ, Hanto DW (2001) A single experience with extrahepatic cholangiocarcinomas. Surgery 130:584–590PubMedCrossRefGoogle Scholar
  74. Kaiho T, Tanaka T, Tsuchiya S, Yanagisawa S, Takeuchi O, Miura M, Saigusa N, Hayasaka A et al (2005) A case of small cell carcinoma of the common bile duct. Hepatogastroenterology 52:363–367PubMedGoogle Scholar
  75. Kayahara M, Nagakawa T, Ueno K, Ohta T, Kanno M, Nakano T, Mori K, Takeda T, Miyazaki I (1992) Surgical-management of carcinoma of the middle and distal bile-duct. Int J Oncol 1:319–323PubMedGoogle Scholar
  76. Kayahara M, Nagakawa T, Ueno K, Ohta T, Takeda T, Miyazaki I (1993) Lymphatic flow in carcinoma of the distal bile duct based on a clinicopathologic study. Cancer 72:2112–2117PubMedCrossRefGoogle Scholar
  77. Kayahara M, Nagakawa T, Tsukioka Y, Ohta T, Ueno K, Miyazaki I (1994) Neural invasion and nodal involvement in distal bile duct cancer. Hepatogastroenterology 41:190–194PubMedGoogle Scholar
  78. Kayahara M, Nagakawa T, Ohta T, Kitagawa H, Tajima H, Miwa K (1999) Role of nodal involvement and the periductal soft-tissue margin in middle and distal bile duct cancer. Ann Surg 299:76–83CrossRefGoogle Scholar
  79. Khan SA, Toledano MB, Taylor-Robinson SD (2008) Epidemiology, risk factors, and pathogenesis of cholangiocarcinoma. HPB (Oxford) 10:77–82CrossRefGoogle Scholar
  80. Khunamornpong S, Lerwill MF, Siriaunkgul S, Suprasert P, Pojchamarnwiputh S, Chiangmai WN et al (2008) Carcinoma of extrahepatic bile ducts and gallbladder metastatic to the ovary: a report of 16 cases. Int J Gynecol Pathol 27:366–379PubMedCrossRefGoogle Scholar
  81. Kim YH (2003) Extrahepatic cholangiocarcinoma associated with clonorchiasis. CT evaluation. Abdom Imaging 28:68–71PubMedCrossRefGoogle Scholar
  82. Kim YC, Park MS (2012) Distal common bile duct metastasis from hepatocellular carcinoma. Hepatology 55:1638–1639PubMedCrossRefGoogle Scholar
  83. Kim DH, Song MH, Kim DH (2006) Malignant carcinoid tumor of the common bile duct: report of a case. Surg Today 36:485–489PubMedCrossRefGoogle Scholar
  84. Kim EM, Lee BS, Moon HS, Sung JK, Kim SH, Lee HY, Kang DY (2009a) Distal cholangiocarcinoma with gastric metastasis mimicking early gastric cancer. Gut Liver 3:222–225PubMedPubMedCentralCrossRefGoogle Scholar
  85. Kim KW, Kim SH, Kim MA, Lee JM, Park HS, Kim JY, Lee JY, Han JK, Choi BI (2009b) Adenosquamous carcinoma of the extrahepatic bile duct: clinicopathologic and radiologic features. Abdom Imaging 34:217–224PubMedCrossRefGoogle Scholar
  86. Kim K, Chie EK, Jang JY, Kim SW, Oh DY, Im SA, Kim TY, Bang YJ, Ha SW (2010) Is duodenal invasion a relevant prognosticator in patients undergoing adjuvant chemoradiotherapy for distal common bile duct cancer? Int J Radiat Oncol Biol Phys 77:1186–1190PubMedCrossRefGoogle Scholar
  87. Kimoto E, Kuno N, Funakawa T (1996) Adenoacanthoma, adenosquamous carcinoma of the extrahepatic bile duct (in Japanese). Ryoikibetsu Shokogun Shirizu 9:47–49PubMedGoogle Scholar
  88. Kiriyama M, Ebata T, Aoba T, Kaneoka Y, Arai T, Shimizu Y, Nagino M (2015) Prognostic impact of lymph node metastasis in distal cholangiocarcinoma. Br J Surg. doi:10.1002/bjs.9752PubMedGoogle Scholar
  89. Kosar I, Ataseven H, Yönem O, Cakmak E, Özer O, Özer H, Topçu O (2010) A new variant of bile duct duplication with coexistence of distal cholangiocarcinoma. Nat Rev Gastroenterol Hepatol 7:527–530PubMedCrossRefGoogle Scholar
  90. Kozuka S, Tsubone M, Hachisuka K (1984) Evolution of carcinoma in the extrahepatic bile ducts. Cancer 54:65–72PubMedCrossRefGoogle Scholar
  91. Kuraoka K, Taniyama K, Fujitaka T, Nakatsuka H, Nakayama H, Yasui W (2003) Small cell carcinoma of the extrahepatic bile duct: case report and immunohistochemical analysis. Pathol Int 53:887–891PubMedCrossRefGoogle Scholar
  92. Kurosaki I, Tsukada K, Hatakeyama K, Muto T (1996) The mode of lymphatic spread in carcinoma of the bile duct. Am J Surg 172:239–243PubMedCrossRefGoogle Scholar
  93. Kuwayti K, Baggenstoss AH, Staufer MH, Priestley JT (1957) Carcinoma of the major and the extrahepatic bile ducts exclusive of the papilla of Vater. Surg Gynecol Obstet 104:357–366PubMedGoogle Scholar
  94. La Greca G, Conti P, Urrico GS, Catanuto G, Di Carlo I, Russello D, Latteri F (2004) Biliary squamous cell carcinoma. Chir Ital 56:289–295PubMedGoogle Scholar
  95. Lad N, Kooby DA (2014) Distal cholangiocarcinoma. Surg Oncol Clin N Am 23:265–287PubMedCrossRefGoogle Scholar
  96. Laitio M (1983) Carcinoma of extrahepatic bile ducts. A histopathologic study. Pathol Res Pract 178:67–72PubMedCrossRefGoogle Scholar
  97. Lantsberg L, Khodadadi J, Goldstein J (1986) Adenosquamous carcinoma of the common bile duct: a case report. J Surg Oncol 33:140–142PubMedCrossRefGoogle Scholar
  98. Läuffer JM, Baer HU, Maurer CA, Fröhling S, Scheurer U, Zimmermann A, Büchler MW (1998) Adenomyoma of the distal common bile duct mimicking cholangiocarcinoma. Dig Dis Sci 43:1200–1204PubMedCrossRefGoogle Scholar
  99. Lee WE, Totten HP (1934) Primary carcinoma of the common bile-duct. Ann Surg 99:930–938PubMedPubMedCentralCrossRefGoogle Scholar
  100. Lee JG, Leung JW, Baillie J, Layfield LJ, Cotton PB (1995) Benign, dysplastic, or malignant – making sense of endoscopic bile duct brush cytology: results in 149 consecutive patients. Am J Gastroenterol 90:722–726PubMedGoogle Scholar
  101. Lee HG, Lee SH, Yoo DD, Paik KY, Heo JS, Choi SH, Choi DW (2009) Carcinoma of the middle bile duct: is bile duct segmental resection appropriate ? World J Gastroenterol 15:5966–5971PubMedPubMedCentralCrossRefGoogle Scholar
  102. Lee EY, Kim C, Kim MJ, Park JY, Park SW, Song SY, Chung JB, Kim H, Bang S (2010a) Signet ring cell carcinoma of the extrahepatic bile duct. Gut Liver 4:402–406PubMedPubMedCentralCrossRefGoogle Scholar
  103. Lee M, Banerjee S, Posner MC, Cartwright CA (2010b) Distal extrahepatic cholangiocarcinoma presenting as cholangitis. Dig Dis Sci 55:1852–1855PubMedCrossRefGoogle Scholar
  104. Levy M, Lin F, Xu H, Dhall D, Spaulding BO, Wang HL (2010) S100P, von Hippel-Lindau gene product, and IMP3 serve as a useful immunohistochemical panel in the diagnosis of adenocarcinoma on endoscopic bile duct biopsy. Hum Pathol 41:1210–1219PubMedCrossRefGoogle Scholar
  105. Lewis JT, Talwalkar JA, Rosen CB, Smyrk TC, Abraham SC (2010) Precancerous bile duct pathology in end-stage primary sclerosing cholangitis, with and without cholangiocarcinoma. Am J Surg Pathol 34:27–34PubMedCrossRefGoogle Scholar
  106. Lim SH, Yang HW, Kim A, Cha SW, Jung SH, Go H, Lee WC (2007) Adenosquamous carcinoma of extrahepatic bile duct: a case report. Korean J Intern Med 22:206–210PubMedPubMedCentralCrossRefGoogle Scholar
  107. Lin CT, Hsu KF, Yu JC, Chu HC, Hsieh CB, Fu CY, Hong ZJ, Chan DC (2009) Choledochoduodenal fistula caused by cholangiocarcinoma of the distal common bile duct. Endoscopy 41(suppl 2):E319–E320PubMedCrossRefGoogle Scholar
  108. Lippman HN, McDonald LC, Longmire WP (1959) Carcinoma of the extrahepatic bile ducts. Am Surg 25:819–826PubMedGoogle Scholar
  109. Longmire WP (1976) Tumors of the extrahepatic biliary radicals. Curr Probl Cancer 1:1–45PubMedCrossRefGoogle Scholar
  110. MacCallum WG (1919) Text-book on pathology. Saunders, Philadelphia, p 984Google Scholar
  111. Martin Malagon A, Lopez-Tomassetti Fernandez E, Arteaga Gonzalez I, Carrilo Pallares A, Diaz Luis H (2006) Inflammatory myofibroblastic tumor of the distal bile duct associated with lymphoplasmacytic sclerosing pancreatitis. Case report and review of the literature. Pancreatology 6:145–154PubMedCrossRefGoogle Scholar
  112. Martin WF, Page GD (1951) Carcinoma of the extrahepatic bile duct; review of recent literature and a case report. South Med J 44:109–114PubMedCrossRefGoogle Scholar
  113. Martins EB, Fleming KA, Garrido MC, Hine KR, Chapman RW (1994) Superficial thrombophlebitis, dysplasia, and cholangiocarcinoma in primary sclerosing cholangitis. Gastroenterology 107:537–542PubMedCrossRefGoogle Scholar
  114. Matsumoto T, Inoue S, Masuo K, Okamoto Y, Fukushima M, Wada M, Shimeno N et al (2011) Signet ring cell carcinoma of the bile duct: a case report (in Japanese). Nihon Shokakibyo Gakkai Zasshi 108:2042–2049PubMedGoogle Scholar
  115. Michelassi F, Erroi F, Dawson PJ, Pietrabissa A, Noda S, Handcock M, Block GE (1989) Experience with 647 consecutive tumors of the duodenum, ampulla, head of the pancreas, and distal common bile duct. Ann Surg 210:544–554PubMedPubMedCentralCrossRefGoogle Scholar
  116. Miyashita T, Konishi K, Noto M (2001) A case of small cell carcinoma of the common bile duct (in Japanese). Nihon Shokakibyo Gakkai Zasshi 98:1195–1198PubMedGoogle Scholar
  117. Mosconi S, Beretta GD, Labianca R, Zampino MG, Gatta G, Heinemann V (2009) Cholangiocarcinoma. Crit Rev Oncol Hematol 69:259–270PubMedCrossRefGoogle Scholar
  118. Moul AE, Bejarano PA, Casillas J, Levi JU, Garcia-Buitrago MT (2013) Mucoepidermoid carcinoma of the intrapancreatic common bile duct: immunohistochemical profile, prognosis, and review of the literature. Case Rep Pathol 2013:192458PubMedPubMedCentralGoogle Scholar
  119. Murakami Y, Uemura K, Hayashidani Y, Sudo T, Ohge H, Sueda T (2007a) Pancreatoduodenectomy for distal cholangiocarcinoma: prognostic impact of lymph node metastasis. Word J Surg 31:337–342CrossRefGoogle Scholar
  120. Murakami Y, Uemura K, Hayashidani Y, Sudo T, Hashimoto Y, Ohge H, Sueda T (2007b) Prognostic significance of lymph node metastasis and surgical margin status for distal cholangiocarcinoma. J Surg Oncol 95:207–212PubMedCrossRefGoogle Scholar
  121. Nagai E, Shinohara M, Yonemasu H, Kishikawa H, Tsuneyoshi M (2002) Undifferentiated carcinoma of the common bile duct: case report and review of the literature. J Hepatobiliary Pancreat Surg 9:627–631PubMedCrossRefGoogle Scholar
  122. Nakao A, Sakagami K, Uda M, Mitsuoka S (1997) Double cancers of the gallbladder and bile duct associated with anomalous choledochopancreatic duct junction. J Gastroenterol 32:110–113PubMedCrossRefGoogle Scholar
  123. Nakeeb A, Pitt HA, Shn TA, Coleman J, Abrams RA, Piantadosi S, Hruban RH, Lillemoe KD et al (1996) Cholangiocarcinoma. A spectrum of intrahepatic, perihilar, and distal tumors. Ann Surg 224:463–473PubMedPubMedCentralCrossRefGoogle Scholar
  124. Neibling HA, Dockerty MB, Waugh JM (1949) Carcinoma of the extrahepatic bile ducts. Surg Gynecol Obstet 89:429–438PubMedGoogle Scholar
  125. Nishimura M, Naka S, Hanazawa K, Tani K, Fukami M, Okada S, Fjiyama Y (2005) Cholangiocarcinoma in the distal bile duct: a probable etiologic association with choledocholithiasis. Dig Dis Sci 50:2153–2158PubMedCrossRefGoogle Scholar
  126. Nomoto S, Nakao A (1996) Papillary extrahepatic bile duct carcinoma, invasive papillary extrahepatic bile duct carcinoma (in Japanese). Ryoikibetsu Shokogun Shirizu 9:88–91PubMedGoogle Scholar
  127. Nomura T, Tsuchiya Y, Nashimoto A, Yabusaki H, Takii Y, Nakagawa S, Sato N, Kanbayashi C et al (2009) Prognostic factors for radical resection of middle and distal bile duct cancer. Hepatogastroenterology 56:294–298PubMedGoogle Scholar
  128. Ogata S, Kimura A, Hatsuse K, Yamamoto J, Shimazaki H, Nakanishi K, Kawai T (2010) Poorly differentiated adenocarcinoma with signet-ring cell carcinoma of the extrahepatic bile duct in a 42-year-old Japanese female: a case report. Acta Med Okayama 64:63–65PubMedGoogle Scholar
  129. Ogawa T, Horaguchi J, Noda Y, Kobayashi G, Ito K, Obana T, Takasawa O, Koshita S et al (2010) A case of distal bile duct cancer with extensive intraepithelial spread diagnosed preoperatively by peroral cholangioscopy combined with narrow band imaging. Nihon Shokakibyo Gakkai Zasshi 107:112–119PubMedGoogle Scholar
  130. Oikawa H, Oka K, Nagakura S, Fukunaga M, Sando N, Kashimura J, Hakozaki H (2007) Spindle and giant cell type undifferentiated carcinoma arising in the common bile duct: a case report. Pathol Res Pract 203:179–184PubMedCrossRefGoogle Scholar
  131. Ojima H, Takenoshita S, Nagamachi Y (2000) Adenomyoma of the common bile duct: report of a case. Hepatogastroenterology 47:132–134PubMedGoogle Scholar
  132. Okabayashi T, Kobayashi M, Nishimori I, Namikawa T, Okamoto K, Onishi S, Araki K (2005) Adenosquamous carcinoma of the extrahepatic biliary tract: clinicopathologic analysis of Japanese cases of this uncommon disease. J Gastroenterol 40:192–199PubMedCrossRefGoogle Scholar
  133. Park HW, Seo SH, Jang BK, Hwang JY, Park KS, Cho KB, Hwang JS, Ahn SH et al (2004) A case of primary small cell carcinoma in the common bile duct (in Korean). Korean J Gastroenterol 43:260–263PubMedGoogle Scholar
  134. Park JS, Park YN, Lee KY, Kim JK, Yoon DS (2013) P16 hypermethylation predicts surgical outcome following curative resection of mid/distal bile duct cancer. Ann Surg Oncol ….Google Scholar
  135. Patel T (2006) Cholangiocarcinoma. Nat Clin Pract 3:33–42CrossRefGoogle Scholar
  136. Permen LE, McCollum EB (1963) Primary carcinoma of the extrahepatic biliary ducts. Henry Ford Hosp Med Bul 11:167–183Google Scholar
  137. Plaza Santos R, Burgos Garcia A, Gea Rodriguez F, Mora Sanz P, Rey Sanz R, Castro Carbajo P et al (2009) Distal biliary stenosis due to bile duct stones simulating cholangiocarcinoma (in Spanish). Gastroenterol Hepatol 32:666–667PubMedCrossRefGoogle Scholar
  138. Pomianowska E, Grzyb K, Westgaard A, Clausen OP, Gladhaug IP (2012) Reclassification of tumour origin in resected periampullary adenocarcinomas reveals underestimation of distal bile duct cancer. Eur J Surg Oncol 38:1043–1050PubMedCrossRefGoogle Scholar
  139. Prat F, Chapat O, Ducot B, Ponchon T, Fritsch J, Choury AD, Pelletier G, Buffet C (1998) Predictive factors for survival of patients with inoperable malignant distal biliary strictures: a practical management guideline. Gut 42:76–80PubMedPubMedCentralCrossRefGoogle Scholar
  140. Ray S, Chatterjee S, Saha AK, Samanta S (2012) Obstructive jaundice due to tuberculosis of distal CBD and periampullary region mimickcholangiocarcinoma. Niger J Surg 18:17–18PubMedPubMedCentralGoogle Scholar
  141. Razumilava N, Gores GJ (2013) Classification, diagnosis, and management of cholangiocarcinoma. Clin Gastroenterol Hepatol 11:13–21PubMedCrossRefGoogle Scholar
  142. Renshaw K (1922) Malignant neoplasms of the extra-hepatic biliary ducts. Ann Surg 76:205–221PubMedPubMedCentralCrossRefGoogle Scholar
  143. Riener MO, Fritzsche FR, Clavien PA, Pestalozzi BC, Probst-Hensch N, Jochum W, Kristiansen G (2009) IMP3 expression in lesions of the biliary tract: a marker for high-grade dysplasia and an independent prognostic factor in bile duct carcinomas. Hum Pathol 40:1377–1383PubMedCrossRefGoogle Scholar
  144. Rijken AM, van Gulik TM, Polak MM, Sturm PD, Gouma DJ, Offerhaus GJ (1998a) Diagnostic and prognostic value of incidence of K-ras codon 12 mutations in resected distal bile duct carcinoma. J Surg Oncol 68:187–192PubMedCrossRefGoogle Scholar
  145. Rijken AM, Umezawa A, van Gulik TM, Bosma A, Polak MM, Offerhaus GJ, Obertop H, Gouma DJ (1998b) Prognostic value of cell proliferation (Ki-67 antigen) and nuclear DNA content in clinically resectable, distal bile duct carcinoma. Ann Surg Oncol 5:699–705PubMedCrossRefGoogle Scholar
  146. Rijken AM, Belien JA, van Gulik TM, Polak MM, Offerhaus GJ, Gouma DJ, Baak JP (1999a) DNA quantitation of distal bile duct carcinoma measured by image and flow cytometry. Anal Quant Cytol Histol 21:303–310PubMedGoogle Scholar
  147. Rijken AM, Offerhaus GJ, Polak MM, Gouma DJ, van Gulik TM (1999b) p53 expression as a prognostic determinant in resected distal bile duct carcinoma. Eur J Surg Oncol 25:297–301PubMedCrossRefGoogle Scholar
  148. Rijken AM, Hu J, Perlman EJ, Morsberger LA, Long P, Kern SE, Hruban RH, Yeo CJ et al (1999c) Genomic alterations in distal bile duct carcinoma by comparative genomic hybridization and karyotype analysis. Genes Chromosom Cancer 26:185–191PubMedCrossRefGoogle Scholar
  149. Rodgers CM, Adams JT, Schwartz SI (1981) Carcinoma of the extrahepatic bile ducts. Surgery 90:596–601PubMedGoogle Scholar
  150. Rokitansky C (1849) A manual of pathological anatomy, vol 2. Sydenham Society, London, p 147Google Scholar
  151. Rolleston HD (1912) Diseases of the liver, gall-bladder and ducts. Macmillan, London, p 811Google Scholar
  152. Sabanathan S, Hashimi H, Nicholson G, Edwards AS (1988) Primary oat cell carcinoma of the common bile duct. JR Coll Surg Edinb 33:285–286Google Scholar
  153. Sakamoto Y, Kosuge T, Shimada K, Sano T, Ojima H, Yamamoto J, Yamasaki S, Takayama T (2005) Prognostic factors of surgical resection in middle and distal bile duct cancer: an analysis of 55 patients concerning the significance of ductal and radial margins. Surgery 137:396–402PubMedCrossRefGoogle Scholar
  154. Sako K, Seitzinger GL, Garside E (1957) Carcinoma of the extrahepatic bile ducts; review of the literature and report of six cases. Surgery 41:416–437PubMedGoogle Scholar
  155. Sano T, Kamiya J, Nagino M, Uesaka K, Oda K, Kanai M, Nimura Y (2003) Bile duct carcinoma arising in metaplastic biliary epithelium of the intestinal type: a case report. Hepatogastroenterology 50:1883–1885PubMedGoogle Scholar
  156. Sato Y, Harada K, Sasaki M, Nakanuma Y (2013) Histological characteristics of biliary intraepithelial neoplasia-3 and intraepithelial spread of cholangiocarcinoma. Virchows Arch 462:421–427PubMedCrossRefGoogle Scholar
  157. Sherrill JG (1906) Cancer of the gall-bladder and ducts. Ann Surg 44:866–891Google Scholar
  158. Schulte SJ, Baron RL, Teefey SA, Rohrmann CA, Freeny PC, Shuman WP, Foster MA (1990) CT of the extrahepatic bile ducts: wall thickness and contrast enhancement in normal and abnormal ducts. AJR Am J Roentgenol 154:79–85PubMedCrossRefGoogle Scholar
  159. Scudder CL, Richardson O (1908) IX. Primary carcinoma of the hepatic ducts: the report of a case with the autopsy. Ann Surg 47:728–729PubMedPubMedCentralCrossRefGoogle Scholar
  160. Sewkani A, Kapoor S, Sharma S, Naik S, Juneja M, Jain A, Varshney S (2005) Squamous cell carcinoma of the distal common bile duct. JOP 6:162–165PubMedGoogle Scholar
  161. Shaib Y, El-Serag HB (2004) The epidemiology of cholangiocarcinoma. Semin Liver Dis 24:115–125PubMedCrossRefGoogle Scholar
  162. Shapiro PF, Lifvendahl RA (1931) Tumors of the extrahepatic bile-ducts. Ann Surg 94:61–79PubMedPubMedCentralCrossRefGoogle Scholar
  163. Shimizu Y, Kimura F, Shimizu H, Yoshidome H, Ohtsuka M, Miyazaki M (2008) The morbidity, mortality, and prognostic factors for ampullary carcinoma and distal cholangiocarcinoma. Hepatogastroenterology 55:699–703PubMedGoogle Scholar
  164. Song BJ, Kwon JH, Kim JJ, Lee JW, Min SY, Lee KB, Jang JY, Ryu JK (2011) A case of primary mucoepidermoid carcinoma arising from the common bile duct (in Korean). Korean J Gastroenterol 57:319–322PubMedCrossRefGoogle Scholar
  165. Sons HU, Borchard F (1987) Carcinoma of the extrahepatic bile ducts: a postmortem study of 65 cases and review of the literature. J Surg Oncol 34:6–12PubMedCrossRefGoogle Scholar
  166. Springer E (1925) New growths involving the terminal bile and pancreatic ducts. Boston Med Surg J 192(21):1035CrossRefGoogle Scholar
  167. Stewart HL, Lieber M, Morgan DR (1940) Carcinoma of the extrahepatic bile ducts. Arch Surg 41:662CrossRefGoogle Scholar
  168. Stutman LJ, Bozian RC (1960) Xanthomatous biliary cirrhosis secondary to carcinoma of the extrahepatic bile ducts. Ann Intern Med 52:229–234PubMedCrossRefGoogle Scholar
  169. Su WC, Chan KK, Lin XZ, Lin PW, Chow NH, Shin JS, Chen CY, Tsao CJ (1996) A clinical study of 130 patients with biliary tract cancers and periampullary tumors. Oncology 53:488–493PubMedCrossRefGoogle Scholar
  170. Takayashiki T, Miyasaki M, Kato A, Ito H, Nakagawa K, Ambiru S, Shimizu H, Furuya S et al (2002) Double cancer of gallbladder and bile duct associated with anomalous junction of the pancreaticobiliary ductal system. Hepatogastroenterology 49:109–112PubMedGoogle Scholar
  171. Tan X, Xiao K, Liu W, Chang S, Zhang T, Tang H (2013) Prognostic factors of distal cholangiocarcinoma after curative surgery: a series of 84 cases. Hepatogastroenterology 60:1892–1895PubMedGoogle Scholar
  172. Thomas D (1970) Carcinoma of the distal extrahepatic bile ducts: case report. Aust N Z J Surg 39:393–395PubMedCrossRefGoogle Scholar
  173. Thorsen MK, Quiroz F, Lawson TL, Smith DF, Foley WD, Stewart ET (1984) Primary biliary carcinoma: CT evaluation. Radiology 152:479–483PubMedCrossRefGoogle Scholar
  174. Tompkins RK, Thomas D, Wile A, Longmire WP (1981) Prognostic factors in bile duct carcinoma: analysis of 96 cases. Ann Surg 194:447–457PubMedPubMedCentralCrossRefGoogle Scholar
  175. Tonsi A, Standish R, Desai C, Davidson BR (2006) Granular cell tumour of the bile duct mimicking distal cholangiocarcinoma: one case report and review of the literature. Minerva Chir 61:247–255PubMedGoogle Scholar
  176. Ustundag Y, Bayraktar Y (2008) Cholangiocarcinoma: a compact review of the literature. World J Gastroenterol 14:6458–6466PubMedPubMedCentralCrossRefGoogle Scholar
  177. van der Wal AC, Van Leeuwen DJ, Walford N (1990) Small cell neuroendocrine (oat cell) tumour of the common bile duct. Histopathology 16:398–400PubMedCrossRefGoogle Scholar
  178. Veillette G, Castillo CF (2008) Distal biliary malignancy. Surg Clin N Am 88:1429–1447PubMedCrossRefGoogle Scholar
  179. Viana Miguel MM, Garcia-Plata Polo E, Vidal Doce O, Aldea Martinez J, de la Plaza Galindo M et al (2006) Oat cell carcinoma of the common bile duct (in Spanish). Cir Esp 80:43–45PubMedCrossRefGoogle Scholar
  180. Wahl HR (1924) Carcinoma of the biliary tract. Med Clin N Am 7:1331–1356Google Scholar
  181. Washington MK, Berlin J, Branton PA, Burgart LJ, Carter DK, Compton CC, Fitzgibbons PL et al (2010) Protocol for the examination of specimens from patients with carcinoma of the distal extrahepatic bile ducts. Arch Pathol Lab Med 134:e8–e13PubMedGoogle Scholar
  182. White RJ (1959) Carcinoma of the larger bile ducts exclusive of the papilla of Vater; report of five personal cases. Ann Surg 149:762–772PubMedPubMedCentralCrossRefGoogle Scholar
  183. Woo SM, Ryu JK, Lee SH, Yoo JW, Park JK, Kim YT, Jang JY, Kim SW, Kang GH et al (2007) Recurrence and prognostic factors of ampullary carcinoma after radical resection: comparison with distal extrahepatic cholangiocarcinoma. Ann Surg Oncol 14:3195–3210PubMedCrossRefGoogle Scholar
  184. Yang HJ, Kim JH, Chun JY, Kim SJ, Lee SH, Kim H, Hwang JH (2012) A case of adenocarcinoma in situ of the distal common bile duct diagnosed by percutaneous transhepatic cholangioscopy. Korean J Intern Med 27:211–215PubMedPubMedCentralCrossRefGoogle Scholar
  185. Yoshida T, Aramaki M, Bandoh T, Kawano K, Sasaki A, Matsumoto T, Morii Y, Kitano S (1998a) Para-aortic lymph node metastasis in carcinoma of the distal bile duct. Hepatogastroenterology 45:2388–2391PubMedGoogle Scholar
  186. Yoshida T, Aramaki M, Matsumoto T, Morii Y, Sasaki A, Kitano S (1998b) The pattern of lymphatic spread in carcinoma of the distal bile duct. Int Surg 83:124–127PubMedGoogle Scholar
  187. Yoshida T, Shibata K, Yokoyama H, Morii Y, Matsumoto T, Sasaki A, Kitano S (1999) Patterns of lymph node metastasis in carcinoma of the distal bile duct. Hepatogastroenterology 46:1595–1598PubMedGoogle Scholar
  188. Young RH (2007) From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part II. Adv Anat Pathol 14:149–177PubMedCrossRefGoogle Scholar
  189. Young RH, Scully RE (1990) Ovarian metastases from carcinoma of the gallbladder and extrahepatic bile ducts simulating primary tumors of the ovary. A report of six cases. Int J Gynecol Pathol 9:60–72PubMedCrossRefGoogle Scholar
  190. Zerbi A, Balzano G, Leone BE, Angeli E, Veronesi P, Di Carlo V (1998) Clinical presentation, diagnosis and survival of resected distal bile duct cancer. Dig Surg 15:410–416PubMedCrossRefGoogle Scholar
  191. Ziegler E (1898) A text-book of special pathological anatomy. Macmillan, London, p 754, sections IX-XVGoogle Scholar

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© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.University of BernBernSwitzerland

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