Combined Hepatocellular-Cholangiocarcinoma

ICD-O code 8180/3
  • Arthur Zimmermann
Reference work entry


Combined hepatocellular-cholangiocarcinoma (CHCC-C) is defined as a tumor that contains unequivocal, intimately mixed elements of both hepatocellular carcinoma and cholangiocarcinoma, resulting in a biphenotypic histologic picture. CHCC-C should not be confounded with collision tumors or rare hepatic mixed tumors. This is a rare liver malignancy of older individuals, probably accounting for less than 5 % of hepatic malignancies. The neoplasm develops in both non-cirrhotic and cirrhotic livers. Etiologic factors include hepatitis virus infections and alcoholic liver disease.

CHCC-C usually presents as a solitary tumor mass. Similar to hepatocellular carcinoma, the tumor tends to invade the portal vein system and bile ducts. Based on distinct histologic patterns, several types of CHCC-C are distinguished in the WHO classification, including a classical type and a type with stem cell features, the latter further subdivided into at least four subtypes. Rare variants of CHCC-C contain sarcomatoid components, or the HCC component is that of fibrolamellar hepatocellular carcinoma. CHCC-Cs are usually highly aggressive lesions with a high rate of metastatic spread.


Hepatocyte Growth Factor Intrahepatic Cholangiocarcinoma Intrahepatic Metastasis Mucin Production Stem Cell Feature 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.University of BernBernSwitzerland

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