The particular sensitivity of the human face to care products prompted us to study irritation induced by sodium lauryl sulfate (SLS) in its various regions. We examined regional and age-related differences, correlating basal transepidermal water loss (TEWL) and capacitance to SLS irritation. SLS (2 % aq.) was applied under occlusion for 1 h to the forehead, cheek, nose, nasolabial and perioral areas, chin, neck, and forearm to two age groups – ten young subjects and ten older subjects. TEWL was measured before and 1 h and 23 h after patch removal. Baseline stratum corneum hydration was also measured. Irritation was assessed by the changes in TEWL (δTEWL = TEWL after patch removal – basal TEWL) after corrections to the control. In the younger group, all areas of the face and the neck reacted to SLS, whereas the forearm did not. In the older group, the nose, perioral area, and forearm did not react. In both age groups, some significant differences between the regions of the face were detected. The younger group showed higher changes in TEWL than the older group in all the areas studied, but only in the chin and nasolabial area were the differences statistically significant. Significant correlations were found between basal TEWL and δTEWL in five of the seven areas which reacted to SLS. Baseline TEWL is one parameter that correlates with the susceptibility of the face to this irritant.
Irritation Face Sodium lauryl sulfate TEWL Age Regional variation Capacitance
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Agner T. Noninvasive measuring methods for the investigation of irritant patch test reactions: a study of patients with hand eczema, atopic dermatitis and controls. Acta Derm Venereol (Stockh). 1992;173(Suppl):1–26.Google Scholar
Agner T, Serup J. Time course of occlusive effects on skin evaluated by measurement of transepidermal water loss (TEWL): including patch tests with sodium lauryl sulphate and water. Contact Dermatitis. 1993;28:6–9.CrossRefPubMedGoogle Scholar
Cua AB, Wilhelm KP, Maibach HI. Cutaneous sodium lauryl sulphate irritation potential: age and regional variability. Br J Dermatol. 1990;123:607–13.CrossRefPubMedGoogle Scholar
Elsner P, Wilhelm D, Maibach HI. Irritant effect of a model surfactant on the human vulva and forearm. J Reprod Med. 1990;35:1035–9.PubMedGoogle Scholar
Lopez RF, Seto JE, Blankschtein D, Langer R. Enhancing the transdermal delivery of rigid nanoparticles using the simultaneous application of ultrasound and sodium lauryl sulphate. Biomaterials. 2011;32:933–41.CrossRefPubMedPubMedCentralGoogle Scholar
Marrakchi S, Maibach HI. Functional map and age related differences in the human face: nonimmunologic contact urticaria induced by hexyl nicotinate. Contact Dermatitis. 2006;55:15–9.CrossRefPubMedGoogle Scholar
Oestmann E, Lavrijsen AP, Hermans J, Ponec M. Skin barrier function as assessed by transepidermal water loss and vascular response to hexyl nicotinate: intra- and inter-individual variability. Br J Dermatol. 1993;128:130–6.CrossRefPubMedGoogle Scholar
Shriner DL, Maibach HI. Regional variation of nonimmunologic contact urticaria: functional map of the human face. Skin Pharmacol. 1996;9:312–21.CrossRefPubMedGoogle Scholar
Tagami H. Location-related differences in structure and function of the stratum corneum with special emphasis on those of the facial skin. Int J Cosmet Sci. 2008;30:413–34.CrossRefPubMedGoogle Scholar
Tupker RA, Coenraads P-R, Pinnagoda J, Nater JP. Baseline transepidermal water loss (TEWL) as a prediction of susceptibility to sodium lauryl sulfate. Contact Dermatitis. 1989;20:265–9.CrossRefPubMedGoogle Scholar
Van Neste D, De Brouwer B. Monitoring of skin response to sodium lauryl sulphate: clinical scores versus bioengineering methods. Contact Dermatitis. 1992;27:151–6.CrossRefPubMedGoogle Scholar
Wilhelm KP, Surber C, Maibach HI. Quantification of sodium lauryl sulfate irritant dermatitis in man: comparison of four techniques: skin color reflectance, transepidermal water loss, laser Doppler flow measurement and visual scores. Arch Dermatol Res. 1989;281:293–5.CrossRefPubMedGoogle Scholar