Injectable Soft Tissues with Fibroblasts and Mesenchymal Cells

  • Neide Kalil GasparEmail author
  • Patricia Shu Kurizky
Living reference work entry

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Part of the Clinical Approaches and Procedures in Cosmetic Dermatology book series (CAPCD)


The use of autologous cells expanded from dermis or mesenchymal cells of adipose tissue has been studied, and it seems to be a promising technique in cosmetic dermatology. This process consists in the implant of expanded cells obtained either by excision of skin graft from occipital area or taken by liposuction from adipose abdominal tissue. Even skin flaps from plastic surgery can be used. These materials are sent to laboratory in appropriate growth medium and expanded after submitted to microbiological control. After about 45 days, it is possible to provide ten syringes containing about 1 million cells each for implants. The patient’s material is cryopreserved for further expansion and other injections. These cells are introduced in dermis by retro-injections. Improvement can be seen after the third week of implantation. This procedure is not approved in Brazil, and authors’ experience is based on their investigative studies. In this chapter, the concept, mechanism of action, and clinical applications are going to be discussed.


Injectable soft tissues Fibroblasts and mesenchymal cells Autologous cells Adipose tissue Skin graft Dermis Implantation Soft tissue augmentation 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Universidade Federal Fluminense (UFF)NiteróiBrazil
  2. 2.Hospital Universitário de BrasíliaBrasíliaBrazil

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