Living reference work entry
Part of the Clinical Approaches and Procedures in Cosmetic Dermatology book series (CAPCD)


There is remarkable evidence among scientific literature that the glycation with the consequence formation of advanced glycation end products (AGEs) participates directly and indirectly (enhancing oxidative stress by stimulating ROS concentration and activity) on the aging process. In the skin, deleterious effect of AGEs is enhanced by UV exposure in sun-exposed areas. Today, glycation treatment is mainly based on preventing AGE formation but AGE scavenger products are being studied. The most promising data refer to studies for the treatment of diabetes. One can suggest the same approach for skin aging as in diabetic subjects by analogy, but the fact is that there are few significant references that support anti-glicants for lowering the aging rate. The “anti-glicants” chapter presents the glycation formation of advanced glycation end product (AGE) theory for aging and its correlation with others theories mainly the theory of oxidative stress and the formation of free radicals (reactive species of oxygen – ROS). The most used and promissory therapeutic approaches are discussed.


Glycation Anti-glycants Advanced glycation end products Aging Skin aging Diabetes Reactive species of oxygen 


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Authors and Affiliations

  1. 1.Serviço de DermatologiaHospital Naval Marcílio DiasRio de JaneiroBrazil

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