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Hydroxy Acids

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Daily Routine in Cosmetic Dermatology

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Abstract

Hydroxy acids (HAs) represent useful substances for skin care and chemical peelings and have been used typically in concentrations ranging from 2 % to 70 %, depending on the indication, pH, formulation, and application schedule. The higher the concentration and the lower the pH of the product, the greater the exfoliative, epidermolytic, and even toxic and corrosive action.

The most widely used hydroxy acids are glycolic, mandelic, and salicylic acids. Recently, other substances like β-lipohydroxy acids (BLHAs) and gluconolactone have been developed in order to enhance efficacy and diminish irritation.

The main effects of hydroxy acids in the skin are hydration, exfoliation, acceleration of collagen synthesis and modulation of matrix degradation, epidermal turnover regulation, inhibition of tyrosinase activity, and free radical neutralization.

The uses of hydroxy acids include the treatment of dry skin, hyperkeratinization, acne, rosacea and sensitive skin, hyperpigmentation, wrinkles, and photoaging, with a high tolerance and good safety profile.

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References

  • Abels C, Kaszuba A, Michalk I, Werdier D, Knie U, Kaszuba A. A 10% glycolic acid containing oil-in water emulsion improves mild acne: a randomized double-blind placebo-controlled trial. J Cosmet Dermatol. 2011;10:202–9.

    Article  PubMed  Google Scholar 

  • Babilas P, Knie U, Abels C. Cosmetic and dermatologic use of alpha hydroxyl acids. J Ger Soc Dermatol. 2012;10:488–91.

    Google Scholar 

  • Bernstein EF, Underhill CB, Lakkakorpi J, et al. Citric acid increases viable epidermal thickness and glycosaminoglycan content of sun-damaged skin. Dermatol Surg. 1997;23:689–94.

    Article  CAS  PubMed  Google Scholar 

  • Bernstein EF, Lee J, Brown DB, et al. Glycolic acid treatment increases type I collagen mRNA and hyaluronic acid content of human skin. Dermatol Surg. 2001;27:1–5.

    Article  Google Scholar 

  • Bernstein EF, Brown DB, Schwart MD, et al. The polyhydroxy acid gluconolactone protects against ultraviolet radiation in and in vitro model of cutaneous photoaging. Dermatol Surg. 2004;30:189–96.

    PubMed  Google Scholar 

  • Ditre CM, Griffin TD, Murphy GF, et al. Effects of α-hydroxy acids on photoaged skin: a pilot clinical, histologic and ultrastructural study. J Am Acad Dermatol. 1996;34:187–95.

    Article  CAS  PubMed  Google Scholar 

  • Draelos ZD, Green BA, Edison BL. An evaluation of a polyhydroxy acid skin care regimen in combination with azelaic acid 15% gel in Rosacea patients. J Cosmet Dermatol. 2006;5:23–9.

    Article  PubMed  Google Scholar 

  • Green B. Lactobionic acid. Skin Inc Mag. 2000;12:62–3.

    Google Scholar 

  • Green B. After 30 years…the future of hydroxyacids. J Cosmet Dermatol. 2005;4:44–5.

    Article  PubMed  Google Scholar 

  • Green BA, Edison BL, Wildnauer RH, Sigler ML. Lactobionic acid and gluconolactone: PHAs for photoaged skin. Cosmet Dermatol. 2001;14:24–8.

    Google Scholar 

  • Green BA, Yu RJ, Van Scott EJ. Clinical and cosmeceutical uses of hydroxy acids. Clin Dermatol. 2009;27:495–501.

    Article  PubMed  Google Scholar 

  • Grimes PE, Green BA, Widnauer RH, Edison BL. The use of polyhydroxy acids (PHAs) in photoaged skin. Cutis. 2004;73(2 Suppl):3–13.

    PubMed  Google Scholar 

  • Grossman K, Matarasso SL. The science of skin care. Curr Opin Otolaryngol Head Neck Surg. 2002;10:292–6.

    Article  Google Scholar 

  • Herrmannn M. Salicylic acid: an old dog, new tricks, and staphylococcal disease. J Clin Invest. 2003;15(3):56–8.

    Google Scholar 

  • Kakita LS, Green BA. A review of the physical and chemical properties of alpha-hydroxyacids (AHAs) and polyhydroxy acids (PHAs) and their therapeutic use in phamacologics. J Am Acad Dermatol. 2006;54:AB107.

    Google Scholar 

  • Kar BR, Tripathy S, Panda M. Comparative study of oral isotretinoin versus oral isotretinoin + 20% salicylic acid peel in the treatment of active acne. Cutan Aesthet Surg. 2013;6(4):204–8.

    Article  Google Scholar 

  • Kessler E, Flanagan K, Chia C, Rogers C, Glaser DA. Comparison of alpha- and beta-hydroxyacid chemical peels in the treatment of mild to moderately severe facial acne vulgaris. Dermatol Surg. 2008;34:45–50 (discussion 1).

    Article  CAS  PubMed  Google Scholar 

  • Kim SJ, Won YH. The effect of glycolic acid on cultured human skin fibroblasts: cell proliferative effect and increased collagen synthesis. J Dermatol. 1998;25:85–9.

    CAS  PubMed  Google Scholar 

  • Klingman D, Klingman AM. Salicylic acid peels for the treatment of photoaging. Dermatol Surg. 1998;24:325–8.

    Google Scholar 

  • Kornhauser A, Coelho SG, Hearing VJ. Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clin Cosmet Investig Dermatol. 2010;3:135–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lavker RM, Kaidbey K, Leyden JJ. Effects of topical ammonium lactate on cutaneous atrophy from a potent topical corticosteroid. J Am Acad Dermatol. 1992;26:535–44.

    Article  CAS  PubMed  Google Scholar 

  • Newman N, Newman A, Moy LS, Babapour R, Harris AG, Moy RL. Clinical improvement of photoaged skin with 50% glycolic acid. A double-blind vehicle-controlled study. Dermatol Surg. 1996;22:455–60.

    CAS  PubMed  Google Scholar 

  • Okano Y, Abe Y, Masaki H, Santhanam U, Ichihashi M, Funasaka Y. Biological effects of glycolic acid on dermal matrix metabolism mediated by dermal fibroblasts and epidermal keratinocytes. Exp Dermatol. 2003;12 Suppl 2:57–63.

    Article  CAS  PubMed  Google Scholar 

  • Petratos MA. Drug Therapies and adjunctive uses of alphahydroxy and polyhydroxy acids. Cutis. 2000;66(2):107–11.

    CAS  PubMed  Google Scholar 

  • Piérard GE, Kligman AM, Stoudemayer T, Lévèque JL. Comparative effects of retinoic acid, glycolic acid and a lipophilic derivative of salicylic acid on photodamaged skin. Dermatology. 1999;199:50–3.

    Article  Google Scholar 

  • Rendl M, Mayer C, Weninger W, Tschachler E. Topically applied lactic acid increases spontaneous secretion of vascular endothelial growth factor by human reconstructed epidermis. Br J Dermatol. 2001;145(1):3–9.

    Article  CAS  PubMed  Google Scholar 

  • Rizer R, Turcott A, Edison B, et al. An evaluation of the tolerance profile of a complete line of gluconolactone-containing skin care formulations in atopic individuals. Skin Aging. 2001a;9(suppl):18–21.

    Google Scholar 

  • Rizer R, Turcott A, Edison B, et al. An evaluation of the tolerance profile of a complete line of gluconolactone-containing skin care in individuals with Rosacea. Skin Aging. 2001b;9(suppl):22–5.

    Google Scholar 

  • Saint-Léger D, Lévêque JL, Verschoore M. The use of hydroxyl acids on the skin: characteristics of C-8 lipohydroxy acid. J Cosmet Dermatol. 2007;6:59–65.

    Article  PubMed  Google Scholar 

  • Tasic-Kostov M, Savic S, Lukic M, Tamburic S, Pavlovic M, Vuleta G. Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid. J Cosmet Dermatol. 2010;9:3–10.

    Article  PubMed  Google Scholar 

  • Tran D, Townley JP, Barnes TM, Greive KA. An antiaging skin care system containing alpha hydroxyl acids and vitamins improves the biomechanical parameters of facial skin. Clin Cosmet Investig Dermatol. 2015;8:9–17.

    CAS  PubMed  Google Scholar 

  • Usuki A, Ohashi Sato H, Ochiai Y, Funasaka Y. The inhibitory effect of glycolic acid and lactic acid on melanin synthesis in melanoma cells. Exp Dermatol. 2003;12 Suppl 2:43–50.

    Article  CAS  PubMed  Google Scholar 

  • Van Scott EJ, Yu RJ. Control of keratinization with α-hydroxyacids and related compounds. Arch Dermatol. 1974;110:586–90.

    Article  PubMed  Google Scholar 

  • Van Scott EJ, Yu RJ. Hyperkeratinization, corneocyte cohesion and alpha hydroxyacids. J Am Acad Dermatol. 1984;11:867–79.

    Article  PubMed  Google Scholar 

  • Yu RJ, Van Scott EJ. Salicylic acid: not a b-hydroxy acid. Cosmet Dermatol. 1997;10:27.

    Google Scholar 

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Authors and Affiliations

  1. Dermatology Department, Federal University of São Paulo (UNIFESP), Rua Estado de Israel, 192, Sao Paulo, Brazil

    Ediléia Bagatin

  2. Translational Medicine Post-Graduation Program, Federal University of São Paulo (UNIFESP), São Paulo, Brazil

    Lilia Ramos dos Santos Guadanhim

Authors
  1. Ediléia Bagatin
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  2. Lilia Ramos dos Santos Guadanhim
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Correspondence to Ediléia Bagatin .

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Editors and Affiliations

  1. Universidade Federal Fluminense, Niterói, São Paulo, Brazil

    Maria Claudia Almeida Issa

  2. Lexbios Medica S/S, São Paulo, São Paulo, Brazil

    Bhertha Tamura

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© 2016 Springer International Publishing Switzerland

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Bagatin, E., Guadanhim, L.R.d.S. (2016). Hydroxy Acids. In: Issa, M., Tamura, B. (eds) Daily Routine in Cosmetic Dermatology. Clinical Approaches and Procedures in Cosmetic Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-319-20250-1_16-1

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  • DOI: https://doi.org/10.1007/978-3-319-20250-1_16-1

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  • Publisher Name: Springer, Cham

  • Online ISBN: 978-3-319-20250-1

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