Treating Type 2 Diabetes Mellitus

  • Alexandra L. Migdal
  • Susan Herzlinger
  • Martin J. Abrahamson
Reference work entry


Type 2 diabetes is a growing problem within the United States and worldwide. Lifestyle modification remains the cornerstone of management, though additional treatment with antihyperglycemic agents is often required. Appropriate management of hyperglycemia is necessary to prevent acute complications and to reduce the risk of long-term complications, including microvascular and macrovascular disease. Treatment goals and management strategies should be individualized to each patient. Fortunately, the majority of patients can be well controlled with currently available agents if managed appropriately. Herein, we review the basic pathophysiology of type 2 diabetes and use this knowledge to review different therapeutic options for managing hyperglycemia associated with type 2 diabetes.


Type 2 diabetes Metformin SGLT-2 inhibitors GLP-1 receptor agonists Sulfonylureas Thiazolidinediones Insulin 


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Alexandra L. Migdal
    • 1
  • Susan Herzlinger
    • 1
  • Martin J. Abrahamson
    • 1
  1. 1.Beth Israel Deaconess Medical Center, Joslin Diabetes CenterHarvard Medical SchoolBostonUSA

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