Critical Care Toxicology pp 1875-1885 | Cite as
Phosphate and Phosphine
Reference work entry
First Online:
Abstract
Pesticides and grain fumigants play an important part in the development of agriculture and enhance grain production in the world. Their use has led to improved quantity and better quality of crops, resulting in better availability of food grains to the population. Despite these benefits, the increased availability of pesticides and grain fumigants has led to them being misused as agents of self-harm [1, 2].
Keywords
Fumigants Aluminum phosphide Phosphine Phosphides Rodenticides Olfactory fatigue Zinc phosphide Calcium phosphide Cytochrome oxidase Potassium permanganate Metabolic acidosis Magnesium N-Acetylcysteine Insulin ECMO Esophageal stricturesReferences
- 1.Murali R, Bhalla A, Singh D, Singh S. Acute poisoning: 15 yr experience of a large north-west Indian hospital. Clin Toxicol. 2008;47:1–4. doi: 10.1080/15563650701885807.Google Scholar
- 2.Gupta S, Ahlawat SK. Aluminium phosphide poisoning: a review. J Toxicol Clin Toxicol. 1995;33:19–24.CrossRefPubMedGoogle Scholar
- 3.Goldman LR, Menge D, Epstien DM, et al. Acute symptoms in person residing near a field treated with soil fumigants. West J Med. 1987;147:95–8.PubMedPubMedCentralGoogle Scholar
- 4.Shadnia S. Fumigants, Chapter 111. In: Hoffman R, Howland MA, Lewin NA, Nelson LS, Goldfrank LR, editors. Goldfrank’s toxicologic emergencies. 10th ed. New York: McGraw Hill Education; 2015. p. 1381–8.Google Scholar
- 5.Singh S, Dilawari JB, Vashist R, Malhotra HS, Sharma BK. Aluminium phosphide ingestion in man. Br Med J. 1985;290:1110–1.CrossRefGoogle Scholar
- 6.Siwach SB, Yadav DR, Arora DR, Arora B, Dalal SJ. Acute aluminium phosphide poisoning. An epidemiological, clinical and histopathological study. J Assoc Physcians India. 1988;36:594–6.Google Scholar
- 7.Chugh SN, Chugh K, Ram S, Malhotra KC. Electrocardiographic abnormalities in aluminium phosphide poisoning with special reference to its incidence, pathogenesis, mortality and histopathology. J Indian Med Assoc. 1991;89:32–5.PubMedGoogle Scholar
- 8.Khosla SN, Chugh SN, Nand N, Saini RS. Systemic involvement in aluminum phosphide poisoning. J Assoc Physcians India. 1986;34:227–30.Google Scholar
- 9.Bajaj R, Wasir HS, Aggarwal R, et al. Clinical toxicity and outcome in eleven intensively monitored patients. Natl Med J India. 1988;1:270–4.Google Scholar
- 10.Kalra R, Elhence GP, Mehrotra ML, Srivastava SSL, Mitra A, Aggarwal R, Ram A. A study of aluminium phosphide poisoning with special reference to electrocardiographic changes. J Assoc Physcians India. 1990;38:471–3.Google Scholar
- 11.Moghdamnia AA, Abdollahi M. An epidemiological study of poisoning in northern Islamic Republic of Iran. East Mediterr Health J. 2002;8:88–94.Google Scholar
- 12.Abder-Rahman HA, Battah AH, Ibraheem YM, Shomaf MS, el- Batanich N. Aluminum phosphide fatalities, new local experience. Med Sci Law. 2000;40:164–813.CrossRefPubMedGoogle Scholar
- 13.Akkaoui M, Achour S, Abidi K, Himdi B, Madani A, Zeggwagh AA, Abouqal R. Reversible myocardial injury associated with aluminium phosphide poisoning. Clin Toxicol. 2007;45(6):728–31.CrossRefGoogle Scholar
- 14.Nocera A, Levitin HW, Hilton JM. Dangerous bodies: a case of fatal aluminium phosphide poisoning. Med J Aust. 2000;173:133–5.PubMedGoogle Scholar
- 15.Popp W, Mentfewitz J, Gotz R, et al. Phosphine gas poisoning in a German office. Lancet. 2002;359:1574.CrossRefPubMedGoogle Scholar
- 16.Brautbar N, Howard J. Phosphine toxicity: report of two cases and review of the literature. Toxicol Ind Health. 2002;18(2):71–5.CrossRefPubMedGoogle Scholar
- 17.Bogle RG, Theron P, Brooks P, et al. Aluminium phosphide poisoning. Emerg Med J. 2006;23:e3.CrossRefPubMedPubMedCentralGoogle Scholar
- 18.Chugh SN. Aluminium phosphide poisoning: present status and management. J Assoc Physicians India. 1992;40:401–5.PubMedGoogle Scholar
- 19.Chugh SN, Malhotra KC. Acute pericarditis in aluminium phosphide poisoning. J Assoc Physicians India. 1992;40:564.PubMedGoogle Scholar
- 20.Zaebst DD, Blade LM, Burroughs GE, Morelli-Schroth P, Woodfin WJ. Phosphine exposures in grain elevators during fumigation with aluminium phosphide. Appl Ind Hyg. 1988;3:146–54.CrossRefGoogle Scholar
- 21.International program on chemical safety for phosphine and selected metal phosphides. Environmental Health Criteria 73. Geneva: WHO;1988. http://www.inchem.org/documents/ehc/ehc73.htm. Accessed 23 Dec 2015.
- 22.Shadania S, Soltaninejad K. Spontaneous ignition due to intentional acute aluminium phosphide poisoning. J Emerg Med. 2011;40:179–81.CrossRefGoogle Scholar
- 23.Wahab A, Rabbani MU, Wahab S, et al. Spontaneous self ignition in case of acute aluminium phosphide poisoning. Am J Emerg Med. 2009;27:752.e5–6.CrossRefGoogle Scholar
- 24.Yadav J, Ahlawat BK, Dubey BP, et al. Spontaneous ignition in case of celphos poisoning. Am J Forensic Med Pathol. 2007;28:353–5.CrossRefPubMedGoogle Scholar
- 25.Balali M. International Program on Chemical Safety (IPCS): Phosphine: poison information monograph 865. Nov 1991. http://www.inchem.org/documents/pims/chemical/pims865.htm. Accessed 23 Dec 2015.
- 26.Goel A, Aggarwal P. Pesticide poisoning. Natl Med J India. 2007;20:182–91.PubMedGoogle Scholar
- 27.Plunkett ER. Handbook of industrial toxicology. 3rd ed. New York: Chemical Publishing Company; 1987. p. 430–2.Google Scholar
- 28.Tripathy SK, Gautam CS, Sharma PL. Clinical pharmacology of aluminium phosphide poisoning. Indian J Pharm. 1992;24:134–7.Google Scholar
- 29.Anger F, Paysant F, Brousse F, et al. Fatal aluminium phosphide poisoning. J Anal Toxicol. 2000;24:90–2.CrossRefPubMedGoogle Scholar
- 30.Chugh SN, Pal R, Singh V, et al. Serial blood phosphine levels in acute aluminium phosphide poisoning. J Assoc Physicians India. 1996;104:190–3.Google Scholar
- 31.Jain AK, Nigam M, Garg SD, Dubey BP, Arora A. Aluminium phosphide poisoning Autopsy findings. JIAFM. 2005;27:35–9.Google Scholar
- 32.Gurjar M, Baronia AK, Azim A, et al. Managing aluminium phosphide poisoning. J Emerg Trauma Shock. 2011;4:378–84.CrossRefPubMedPubMedCentralGoogle Scholar
- 33.Nakakita H, Katsumata Y, Ozawa T. The effect of phosphine on the respiration of rat liver mitochondria. J Biochem. 1971;68:589–93.Google Scholar
- 34.Chefurka W, Kashi KP, Bond EJ. The effect of phosphine on electron transport in mitochondria. Pesticide Biochem Physio. 1976;6:65–84.CrossRefGoogle Scholar
- 35.Price NR, Dance SJ. Some biochemical aspect of phosphine action and resistance in three stored product beetles. Comp Biochem Physiol. 1983;76:277–81.Google Scholar
- 36.Dua R, Gill KD. Effect of aluminium phosphide exposure on kinetic properties of cytochrome oxidase and mitochondrial energy metabolism in rat brain. Biochim Biophys Acta. 1674;2004:4–11.Google Scholar
- 37.Dua R, Gill KD. Aluminum phosphide exposure: implications on rat brain lipid peroxidation and anti-oxidant defence system. Pharmacol Toxicol. 2001;89:315–9.CrossRefPubMedGoogle Scholar
- 38.Singh S, Kumar S, Kaur A, Bhalla A, Gill KD. Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients. Clin Toxicol. 2006;44(3):155–8.CrossRefGoogle Scholar
- 39.Chugh SN, Mittal A, Seth S, et al. Lipid peroxidation in acute aluminium poisoning. J Assoc Physicians India. 1995;43:265–6.PubMedGoogle Scholar
- 40.Chugh SN, Arora V, Sharma A, et al. Free radical scavengers and lipid peroxidation in acute aluminium phosphide poisoning. Indian J Med Res. 1996;104:190–3.PubMedGoogle Scholar
- 41.Anand R, Kumari P, Kaushal A, Bal A, Wani WY, Sunkaria A, Dua R, Singh S, Bhalla A, Gill KD. Effect of aluminium phosphide exposure on rats-a biochemical and histological correlation. Toxicol Lett. 2012;215:62–9.CrossRefPubMedGoogle Scholar
- 42.Sharma N, Mahi S, Bhalla A, APAMT 2007) Bhalla A, Mahi S, Sharma N, Singh S. Polyserositis: an unusual complication of aluminium phosphide poisoning. Asia Pac J Med Toxicol. 2012;1(1): 1407.Google Scholar
- 43.NIOSH: Preventing phosphine and explosions during fumigation. Publication No 11–126. http://www.cdc.gov/niosh/docs/99-126/pdfs/99-126.pdf. Accessed 22 Jan 2016.
- 44.Sudakin DL. Occupational exposure to aluminium phosphide and phosphine gas? A suspected case report and review of literature. Hum Exp Toxicol. 2005;24:27–33.CrossRefPubMedGoogle Scholar
- 45.Bajaj R, Wasir HS. Epidemic aluminium phosphide poisoning in northern India. Lancet. 1988;1(8589):820–1.CrossRefGoogle Scholar
- 46.Singh S, Singh D, Wig N, Inderjit, Sharma BK. Aluminium phosphide ingestion- A clinico-pathologic study. J Toxicol Clin Toxicol. 1996;34:703–6.CrossRefPubMedGoogle Scholar
- 47.Chugh SN, Sant R, Chugh K, Malhotra KC. Spot diagnosis of aluminium phosphide ingestion; an application of simple test. J Assoc Physcians India. 1989;37:219–20.Google Scholar
- 48.Mathiharan K, Patnaik AK. Modi’s medical jurisprudence and toxicology. 23rd ed. Nagpur (India): LexisNexis Butterworth Wadhwa;2005. p. 436.Google Scholar
- 49.Bansal YS, Singh D, Settia P, Attrey SD. Precautions while conducting silver nitrate test for aluminium phosphide. J Ind Acad For en Med. 2006;28(3):88–90.Google Scholar
- 50.Musshoff F. Gas chromatographic analysis of phosphine in biological material in a case of suicide. Forensic Sci Int. 2008;177:e35–8.CrossRefPubMedGoogle Scholar
- 51.Vins Jansen A, Thrane KE. Gas chromatographic determination of phosphine in ambient air. Analysis. 1978;103:1195–8.Google Scholar
- 52.Jain SM, Bharani A, Sepaha GC, et al. Electrocardiographic changes in aluminium phosphide poisoning. J Assoc Physicians India. 1985;33:406–9.PubMedGoogle Scholar
- 53.Soltaninejad K, Beyranvand MR, Momenzedeh SA, et al. Electrocardiographic findings and cardiac manifestations in acute aluminium phosphide poisoning. J Forenisc Legal Med. 2012;19:291–3.CrossRefGoogle Scholar
- 54.Siwach SB, Singh H, Jagdish, et al. Cardiac arrhythmias in aluminium phosphide poisoning studied by continuous holter and cardioscopic monitoring. J Assoc Physicians India. 1998;46:598–601.PubMedGoogle Scholar
- 55.Bhasin P, Mittal HS, Mitra A. An echocardiographic study in aluminium phosphide poisoning. (abstract). J assoc Physicians India. 1991; 39:851.Google Scholar
- 56.Gupta MS, Malik A, Sharma VK, et al. Cardiovascular manifestations in aluminium phosphide poisoning with special reference to echocardiographic changes. J Assoc Physicians India. 1995;43:773.PubMedGoogle Scholar
- 57.Proudfoot AT. Zinc and aluminium phosphide poisoning. Clin Toxicol. 2009;47:89–100.CrossRefGoogle Scholar
- 58.Chugh SN, Kumar P, Sharma A, et al. Magnesium status and magnesium sulphate therapy in acute aluminium phosphide intoxication. Magnes Res. 1994;7:289–94.PubMedGoogle Scholar
- 59.Chugh SN, Kumar P, Aggarwal HK, et al. Efficacy of magnesium sulphate in acute aluminium phosphide poisoning. J Assoc Physicians India. 1994;42:373–5.PubMedGoogle Scholar
- 60.Singh RB, Saharia RB, Sharma VK. Can aluminium phosphide cause hypermagnesemia? A study of 121 patients. Magnes Trace Elem. 1990;9:212–8.PubMedGoogle Scholar
- 61.Singh RB, Singh RG, Singh U. Hypermagnesemia following aluminium phosphide poisoning. Int J Ciln Pharm Ther Toxicol. 1991;29:82–5.Google Scholar
- 62.Chugh SN, Kishore K, Aggarwal N, et al. Hypoglycaemia in acute aluminium phosphide poisoning. J Assoc Physicians India. 2000;48:855–6.PubMedGoogle Scholar
- 63.Frangides CY, Pneumatikos IA. Persistent severe hypoglycaemia in severe aluminium phosphide poisoning. Intensive Care Med. 2002;28:223.CrossRefPubMedGoogle Scholar
- 64.Mehrpour O, Dolati M, Soltaninejad K, et al. Evaluation of histopathological changes in fatal aluminium phosphide poisoning. Indian J Forensic Med Toxicol. 2008;2:34–8.Google Scholar
- 65.Maitai CK, Njoroge DK, Abuga KO, et al. Investigation of possible antidotal effects of activated charcoal, sodium bicarbonate, hydrogen peroxide and potassium permanganate in zinc phosphide poisoning. East Central Afr J Phram Sci. 2002;5:38–41.Google Scholar
- 66.Pajoumand A, Jalali N, Abdollahi M, et al. Survival after acute aluminium phosphide poisoning. J Pharm Pract Res. 2002;32:297–9.CrossRefGoogle Scholar
- 67.Goswami L, Bindal M, Sen P, et al. Fat and oil inhibit release of phosphine from aluminium phosphide-its clinical implications. Indian J Exp Biol. 1994;32:647–9.PubMedGoogle Scholar
- 68.Shadnia S, Rahimi M, Pajoumand A, et al. Successful treatment of acute aluminium phosphide poisoning, possible benefit of coconut oil. Hum Exp Toxicol. 2005;24:215–8.CrossRefPubMedGoogle Scholar
- 69.Mital HS, Mehrotra TN, Dwivedi KK, et al. A study of aluminium phosphide poisoning with special reference to silver nitrate test. J Assoc Physcians India. 1992;40:473–4.Google Scholar
- 70.Christophers AJ, Singh S, Goddard DG. Dangerous bodies: a case of fatal aluminium phosphide poisoning. MJA. 2002;176(8):403.PubMedGoogle Scholar
- 71.Abu-Zidan FM. Optimizing the value of measuring inferior vena cava diameter in shocked patients. World J Crit Care Med. 2016;5(1):7–11.CrossRefPubMedPubMedCentralGoogle Scholar
- 72.Moazezi Z, Abedi SH. A successful management of aluminium phosphide intoxication. Caspian J Intern Med. 2011;2(3):286–8.PubMedPubMedCentralGoogle Scholar
- 73.Mehrpour O, Ferzaneh E, Abdollahi M. Successful treatment of aluminium phosphide poisoning with Digoxin: a case report and review of literature. Int J Pharmacol. 2011;7:761–4.CrossRefGoogle Scholar
- 74.Sanei-zadeh H, Farajidana H. Is there a role of digoxin in the management of aluminium phosphide poisoning? Med Hypotheses. 2011;76:756–66.Google Scholar
- 75.Chugh SN, Ram S, Arora RB, Saini AS, Malhotra KC. Adrenocortical involvement in aluminium phosphide poisoning. Indian J Med Res. 1989;90:289–94.PubMedGoogle Scholar
- 76.Azad A, Lall SB, Mitra S. Effect of N-acetylcysteine and L-NAME on aluminum phosphide induced cardiovascular toxicity in rats. Acta Pharmacol Sin. 2001;22:298–304.PubMedGoogle Scholar
- 77.Tehrani H, Halvaie Z, Shadnia S, et al. Protective effects of N acetyl cysteine on aluminium phosphide induced oxidative stress in acute human poisoning. Clin Toxicol. 2013;51:23–8.CrossRefGoogle Scholar
- 78.Bhalla A, Jyotinath P, Singh S, Sharma N. Antioxidant therapy in patients with severe aluminium phosphide poisoning-A pilot study. Indian Jr Critical care medicine (in press).Google Scholar
- 79.Marquis JK, Lerrick AJ. Non competitive inhibition by aluminium, scandium and yttrium of acetylcholinesterase from electrophorus electricus. Biochem Pharmacol. 1982;31:1437–40.CrossRefPubMedGoogle Scholar
- 80.Marquis JK. Aluminium inhibition of human serum cholinesterase. Bull Environ Contam Toxicol. 1983;31:164–9.CrossRefPubMedGoogle Scholar
- 81.Potter WT, Garry VF, Kelly JT, et al. Radiometric assay of red cell and plasma cholinesterase in pesticide appliers of Minnesota. Toxicol Appl Pharmacol. 1993;119:150–5.CrossRefPubMedGoogle Scholar
- 82.Hassanian Moghaddam H, Pajoumand A. Two years epidemiological survey of aluminium phosphide poisoning. Iranian J Toxicol. 2007;1:1–9.Google Scholar
- 83.Siddaiah L, Adhyapak S, Jaydev S, et al. Intra aortic balloon pump in toxic myocarditis due to aluminium phosphide poisoning. J Medical Toxicol. 2009;5:80–3.CrossRefGoogle Scholar
- 84.Hassanian Moghaddam H, Zamani N, Rahimii M, Hajesmaeili M, Teherkhani M, Sadeghi R. Successful treatment of aluminium phosphide poisoning by extra corporeal membrane oxygenation. Basic Clin Pharmacol Toxicol. 2016;118(3):243–6.CrossRefPubMedGoogle Scholar
- 85.Saidi H, Shokranesh F, Ghafouri HB, et al. Effect of hyperbaric oxygen on survival time of aluminium phosphide intoxicated rats. J Res Med Sci. 2011;16:1306–12.PubMedPubMedCentralGoogle Scholar
- 86.Misra SP, Dwivedi M. Aluminium phosphide induced esophageal strictures. J Clin Gastroenterol. 2009;43(5):405–9.CrossRefPubMedGoogle Scholar
- 87.Kochhar R, Dutta U, Poornachandra KS, Vaiphai K, Bhagat S, Nagi B, Singh K. Clinical profile and outcome of aluminium phosphide induced esophageal strictures. J Med Toxicol. 2010;6(3):301–6.CrossRefPubMedPubMedCentralGoogle Scholar
- 88.Jain RK, Gouda NB, Sharma VK, Dubey TN, Shende A, Malik R, Tiwari G. Esophageal complications following aluminium phosphide ingestion: an emerging issue among survivors of poisoning. Dysphagia. 2009;25:271–6.CrossRefPubMedGoogle Scholar
- 89.Louriz M, Dendane T, Abidi K, Madani N, Abouqal R, Zeggwagh AA. Prognostic factors of acute aluminum phosphide poisoning. Indian J Med Sci. 2009;63(6):227–34.CrossRefPubMedGoogle Scholar
- 90.Shadnia S, Mehrpour O, Soltaninejad S. A simplified acute physiology score in the prediction of acute aluminum phosphide poisoning outcome. Indian Jr Med Sci. 2010;64:532–5.CrossRefGoogle Scholar
- 91.Singh S, Bhalla A. Aluminium phosphide poisoning. Jr Mahatama Gandhi Inst Med Sci. 2015;20:15–9.CrossRefGoogle Scholar
- 92.Bhalla A, Jhuria L, Sharma N, Kumar S, Singh S. Comparing three point PGI scoring system with SAPS II and SOFA score as prognostic marker in acute aluminium phosphide poisoning. 13th APAMT Meeting 2014, Shenyang. www.asiatox.org/13thAPAMT/OP/oral presentation_pdf. Accessed 24 Mar 2016.
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