Reference work entry


-Acetylcysteine (NAC) was originally marketed in 1963 as Mucomyst® [1] for inhalation use as a mucolytic due to its ability to break disulfide bonds in mucoprotein complexes in chronic bronchopulmonary disease [2]. It was then studied as an antidote for acetaminophen (paracetamol; APAP) poisoning in the 1970s and since then has been the standard of care for treatment of APAP toxicity. NAC has also been investigated as an antidote for many other toxicants [3–13].


N-Acetylcysteine Acetaminophen Paracetamol Glutahione 



Anthony S Manoguerra, PharmD, contributed to this chapter in the first edition.


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of PharmacyMcGill University Health CentreMontrealCanada
  2. 2.Department of Medicine and Emergency MedicineMcGill University Health CentreMontrealCanada

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