Handbook of Gynecology pp 443-457 | Cite as
Hyperandrogenism: Acne and Hirsutism
Abstract
Hyperandrogenism is a common pathology in women, with the main physical manifestations including hirsutism and acne. Etiologies include polycystic ovarian syndrome (PCOS), idiopathic hirsutism, classical and nonclassical congenital adrenal hyperplasia (CAH), ovarian and adrenal tumors, Cushing’s disease, and certain medications. The severity of the hirsutism will vary among patients, but treatment should be administered to those who desire it, even if their hirsutism is not severe. Treatment methods include weight reduction, hair removal, oral contraceptive pills, and antiandrogen medications including spironolactone, finasteride, cyproterone acetate, flutamide, and eflornithine. Treatments for acne include topical retinoids, topical antimicrobials (benzoyl peroxide), topical antibiotics (erythromycin, clindamycin, sulfacetamide, dapsone), or oral isotretinoin.
Keywords
Hyperandrogenism Polycystic ovarian syndrome Hirsutism Virilization AcneReferences
- Adams J, Polson DW, Franks S. Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism. Br Med J. 1986;293(6543):355–9.CrossRefGoogle Scholar
- Azziz R, Carmina E, Sawaya ME. Idiopathic hirsutism. Endocr Rev. 2000;21(4):347–62.PubMedGoogle Scholar
- Barbieri RL. Treatment of hirsutism. Wolters Kluwer Health; 2013. Available from: Web 2 Mar 2015. http://www.uptodate.com/contents/treatment-of-hirsutism?source=search_result&search=treatment%2Bof%2Bhirsutism&selectedTitle=1~128
- Barbieri RL, Ehrmann DA. Evaluation of premenopausal women with hirsutism. Wolters Kluwer Health; 2013a. Web 24 Nov 2014. http://www.uptodate.com/contents/evaluation-of-premenopausal-women-with-hirsutism
- Barbieri RL, Ehrmann DA. Pathogenesis and causes of hirsutism. Wolters Kluwer Health; 2013b. Available from: Web 27 Feb 2015. http://www.uptodate.com/contents/pathogenesis-and-causes-of-hirsutism
- Carr B, Breslau N, et al. Oral contraceptive pill, GnRH agonist, or use in combination for treatment of hirsutism. J Clin Endocrinol Metab. 1995;60(4):1169.Google Scholar
- Cosma M, Swiglo BA, Flynn DN, et al. Clinical review: insulin sensitizers for the treatment of hirsutism: a systematic review and metaanalyses of randomized controlled trials. J Clin Endocrinol Metab. 2008;93:1135.CrossRefPubMedGoogle Scholar
- Demidov VN, Lipatenkova J, Vikhareva O, Van Holsbeke C, Timmerman D, Valentin L. Imaging of gynecological disease (2): clinical and ultrasound characteristics of Sertoli cell tumors, Sertoli-Leydig cell tumors and Leydig cell tumors. Ultrasound Obstet Gynecol. 2008;31(1):85–91.CrossRefPubMedGoogle Scholar
- Dorn C, Mouillet JF, Yan X, Ou Q, Sadovsky Y. Insulin enhances the transcription of luteinizing hormone-beta gene. Am J Obstet Gynecol. 2004;191(1):132–7.CrossRefPubMedGoogle Scholar
- Goljan EF, Sloka KI. Endocrine disorders rapid review laboratory testing in clinical medicine. Philadelphia: Mosby Elsevier; 2007. p. 365–70.Google Scholar
- Grabber E. Treatment of acne vulgaris. Wolters Kluwer Health; 2015. Available from: Web 27 Mar 2015. http://www.uptodate.com/contents/treatment-of-acne-vulgaris?source=search_result&search=treatment%2Bof%2Bacne&selectedTitle=1~150#H1
- Lebovic DI, Gordon JD, Taylor RN. Polycystic ovarian syndrome. In: Reproductive endocrinology and infertility: handbook for clinicians. Arlington: Scrub Hill; 2013a. p. 194–6.Google Scholar
- Lebovic DI, Gordon JD, Taylor RN. Polycystic ovarian syndrome. In: Reproductive endocrinology and infertility: handbook for clinicians. Arlington: Scrub Hill; 2013b. p. 186–9.Google Scholar
- Lebovic DI, Gordon JD, Taylor RN. Polycystic ovarian syndrome. In: Reproductive endocrinology and infertility: handbook for clinicians. Arlington: Scrub Hill; 2013c. p. 197–9.Google Scholar
- Miller KK, Rosner W, Lee H, et al. Measurement of free testosterone in normal women and women with androgen deficiency: comparison of methods. J Clin Endocrinol Metab. 2004;89(2):525–33.CrossRefPubMedGoogle Scholar
- Phipps WR. Polycystic ovary syndrome and ovulation induction. Obstet Gynecol Clin North Am. 2001;28(1):165.CrossRefPubMedGoogle Scholar
- Rotterdam EA-SPcwg. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19(1):41–7.CrossRefGoogle Scholar
- Schorge JO, Williams JW. Polycystic ovarian syndrome and hyperandrogenism: introduction. In: Williams gynecology. New York: McGraw-Hill Medical; 2008a. p. 779–91.Google Scholar
- Schorge JO, Williams JW. Polycystic ovarian syndrome and hyperandrogenism: introduction. In: Williams gynecology. New York: McGraw-Hill Medical; 2008b. p. 785.Google Scholar
- Speiser PW. Congenital adrenal hyperplasia owing to 21-hydroxylase deficiency. Endocrinol Metab Clin North Am. 2001;30(1):31–59, vi.CrossRefPubMedGoogle Scholar
- Wild RA, Carmina E, Diamanti-Kandarakis E, et al. Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society. J Clin Endocrinol Metab. 2010;95(5):2038–49.CrossRefPubMedGoogle Scholar