Body Temperature Regulation
Thermoregulation is the process through which the central nervous system employs information from temperature and other sensors to adjust the activity of tissues that are specifically responsible for heat production and those that regulate heat loss from the body.
In mammals, the temperature of the body core (Tcore) is a critical physiological variable that is tightly regulated to optimize cellular function, in particular enzyme kinetics and membrane ion flows. Tcore represents the heat content of the body, which is the balance point between the heat produced by the metabolic processes of the body and the heat lost from the body to the ambient environment. The primary basis for heat production is the breakdown of ATP, the energy molecule which most cells employ to accomplish their basic and tissue-specific functions. The conversion of ATP to ADP to perform work is an inefficient process in which approximately 50% of the triphosphate...
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