Pleiotropy
Definition
When a single gene has multiple phenotypic effects.
Introduction
The founder of genetics, Austrian friar Gregor Mendel, observed in his pea-plant experiments that three phenotypic traits were inherited together in one of two sets: “brown seed coat, violet flowers, and axial spots or a white seed coat, white flowers, and lack of spots” (Stearns 2010, p. 767). Such strong covariation in phenotypic traits likely resulted from changes of a single gene. A single gene influencing multiple phenotypic traits is referred to as pleiotropy, a term introduced in 1910 by Ludwig Plate, a German geneticist (Stearns 2010). For evolutionary psychologists, pleiotropy has been especially important for the evolutionary explanation of aging and its role in human diseases and apparently fitness-reducing behaviors.
Evolutionary Theory of Aging
Medawar (1952) first suggested that pleiotropic genes could result in the evolution of senescence – increased mortality with advancing age – but he did so...
Keywords
Seed Coat Phenotypic Trait Antagonistic Pleiotropy Pleiotropic Gene Molecular Genetic MechanismReferences
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